{"id":"https://openalex.org/W2016373112","doi":"https://doi.org/10.1115/imece2006-14694","title":"Chemotherapy Drug Encapsulated Poly(Lactic-Co-Glycolic Acid) Nanoparticles","display_name":"Chemotherapy Drug Encapsulated Poly(Lactic-Co-Glycolic Acid) Nanoparticles","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2016373112","doi":"https://doi.org/10.1115/imece2006-14694","mag":"2016373112"},"language":"en","primary_location":{"id":"doi:10.1115/imece2006-14694","doi":"https://doi.org/10.1115/imece2006-14694","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece2006-14694","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials, Nondestructive Evaluation, and Pressure Vessels and Piping","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072845022","display_name":"Ambalangodage Champa Jayasuriya","orcid":"https://orcid.org/0000-0001-6171-5569","observed_orcids":["https://orcid.org/0000-0001-6171-5569"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Champa Jayasuriya","raw_affiliation_strings":["University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034712658","display_name":"Anthony J. Darr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Darr","raw_affiliation_strings":["University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005003253","display_name":"Nabil A. Ebraheim","orcid":"https://orcid.org/0000-0002-0950-3689","observed_orcids":["https://orcid.org/0000-0002-0950-3689"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabil A. Ebraheim","raw_affiliation_strings":["University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09340659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"251","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-cancer","display_name":"bone cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nanoparticle-synthesis","display_name":"nanoparticle synthesis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-toxicity-reduction","display_name":"drug toxicity reduction","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2780472526","wikidata":"https://www.wikidata.org/wiki/Q409373","display_name":"Glycolic acid","level":4,"score":0.8834317326545715},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.8039807677268982},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6960511207580566},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6763566732406616},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5935034155845642},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5721663236618042},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5618809461593628},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.4926672577857971},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4323109984397888},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.41114991903305054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4109017252922058},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32637983560562134},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.26209211349487305},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2543642520904541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.192496657371521},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12402740120887756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10966011881828308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06306192278862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/imece2006-14694","doi":"https://doi.org/10.1115/imece2006-14694","is_oa":false,"landing_page_url":"https://doi.org/10.1115/imece2006-14694","pdf_url":null,"source":{"id":"https://openalex.org/S4363606942","display_name":"ASME International Mechanical Engineering Congress and Exposition (IMECE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials, Nondestructive Evaluation, and Pressure Vessels and Piping","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1544827405","https://openalex.org/W1973189310","https://openalex.org/W1987489472","https://openalex.org/W1999204999","https://openalex.org/W2061389108","https://openalex.org/W2066845679","https://openalex.org/W2070342688","https://openalex.org/W2073504310","https://openalex.org/W2084071045","https://openalex.org/W2097202569","https://openalex.org/W2120292596","https://openalex.org/W2172168764","https://openalex.org/W2336007082"],"related_works":["https://openalex.org/W3176922329","https://openalex.org/W2049776526","https://openalex.org/W9292960","https://openalex.org/W4206873924","https://openalex.org/W2062772191","https://openalex.org/W2003381115","https://openalex.org/W2027560573","https://openalex.org/W2015754794","https://openalex.org/W1966687729","https://openalex.org/W2069192207"],"abstract_inverted_index":{"In":[0,55],"order":[1],"to":[2,15,28,31,44],"exhibit":[3],"pharmacological":[4],"activity":[5],"at":[6],"the":[7,32,45],"bone":[8],"cancer":[9],"site,":[10],"high-dose":[11],"chemotherapy":[12,72],"drugs":[13],"need":[14],"be":[16],"used.":[17],"This":[18],"often":[19],"causes":[20],"toxicity":[21],"and":[22,61],"unfavorable":[23],"systemic":[24],"adverse":[25],"effects":[26],"leading":[27],"significant":[29],"problems":[30],"patient.":[33],"Since":[34],"nanoparticles":[35],"are":[36],"in":[37,51],"subcellular":[38],"size,":[39],"they":[40],"can":[41],"effectively":[42],"entered":[43],"cell":[46],"membrane":[47],"that":[48],"could":[49],"result":[50],"higher":[52],"cellular":[53],"uptake.":[54],"this":[56],"study,":[57],"we":[58],"report":[59],"preparation":[60],"characterization":[62],"of":[63],"poly(lactic-co-glycolic":[64],"acid)":[65],"-":[66],"PLGA":[67],"nanoparticles,":[68],"which":[69],"encapsulated":[70],"with":[71],"drug":[73],"cisplatin.":[74]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}