{"id":"https://openalex.org/W2016372802","doi":"https://doi.org/10.1016/j.jalz.2010.05.401","title":"O3\u201002\u201005: Cognitive correlates of frontotemporal amyloid deposition in presymptomatic APOE e4 carriers","display_name":"O3\u201002\u201005: Cognitive correlates of frontotemporal amyloid deposition in presymptomatic APOE e4 carriers","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2016372802","doi":"https://doi.org/10.1016/j.jalz.2010.05.401","mag":"2016372802"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2010.05.401","doi":"https://doi.org/10.1016/j.jalz.2010.05.401","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.05.401","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074086871","display_name":"Richard J. Caselli","orcid":"https://orcid.org/0000-0001-5784-2987","observed_orcids":["https://orcid.org/0000-0001-5784-2987"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Caselli","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090009905","display_name":"Amylou Constance Dueck","orcid":"https://orcid.org/0000-0002-9912-1085","observed_orcids":["https://orcid.org/0000-0002-9912-1085"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amylou C. Dueck","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069829137","display_name":"Dona E.C. Locke","orcid":"https://orcid.org/0000-0002-1966-7716","observed_orcids":["https://orcid.org/0000-0002-1966-7716"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dona E.C. Locke","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076952650","display_name":"Charlene Hoffman\u2010Snyder","orcid":"https://orcid.org/0000-0002-1482-556X","observed_orcids":["https://orcid.org/0000-0002-1482-556X"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlene Hoffman-Snyder","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069754665","display_name":"Scott W Findley","orcid":"https://orcid.org/0000-0002-5066-6877","observed_orcids":["https://orcid.org/0000-0002-5066-6877"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Findley","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068423077","display_name":"Bryan Keith Woodruff","orcid":"https://orcid.org/0000-0002-4728-7294","observed_orcids":["https://orcid.org/0000-0002-4728-7294"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan K. Woodruff","raw_affiliation_strings":["Mayo Clinic Scottsdale, Scottsdale, AZ USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Scottsdale, Scottsdale, AZ USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047768726","display_name":"Eric M. Reiman","orcid":"https://orcid.org/0000-0002-0705-3696","observed_orcids":["https://orcid.org/0000-0002-0705-3696"]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Reiman","raw_affiliation_strings":["Banner Alzheimer Institute, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer Institute, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4387152203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15812731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4S_Part_4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.6669312119483948},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6502779126167297},{"id":"https://openalex.org/C2778420670","wikidata":"https://www.wikidata.org/wiki/Q549525","display_name":"Wisconsin Card Sorting Test","level":4,"score":0.588463544845581},{"id":"https://openalex.org/C2776811091","wikidata":"https://www.wikidata.org/wiki/Q3818443","display_name":"Neuropsychological test","level":4,"score":0.5240756869316101},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47013410925865173},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.46489468216896057},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4550352096557617},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.4366391599178314},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.42974767088890076},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3895376920700073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2823602557182312},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2468140423297882},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.24208122491836548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17837175726890564},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10326483845710754},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2010.05.401","doi":"https://doi.org/10.1016/j.jalz.2010.05.401","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.05.401","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088389101","https://openalex.org/W3022484439","https://openalex.org/W4206046100","https://openalex.org/W2236000837","https://openalex.org/W7164129724","https://openalex.org/W2064336966","https://openalex.org/W3082601701","https://openalex.org/W2051530804","https://openalex.org/W4290844298","https://openalex.org/W2159925726"],"abstract_inverted_index":{"Frontotemporal":[0],"and":[1,69,88,108,136,143,168,177,211,309,341,360],"posterior":[2],"cingulate":[3],"cortices":[4],"are":[5],"preferentially":[6],"associated":[7],"with":[8,191,207],"fibrillar":[9],"amyloid":[10,77],"deposition":[11],"in":[12,37,42,64,181,220,255,351],"cognitively":[13,30],"healthy":[14,65],"60":[15],"year":[16],"old":[17],"APOE":[18,66,92,260,294,331,353],"e4":[19,32,67,189,199,203,213,261,295,332,354],"carriers":[20,33,68,190,262,296],"(Reiman":[21],"et":[22,50],"al,":[23,51],"2009),":[24],"yet":[25],"we":[26,157],"failed":[27],"to":[28,71,113],"distinguish":[29],"normal":[31,80],"from":[34],"noncarriers":[35,214],"(NC)":[36,215],"cross-sectional":[38],"or":[39,235,245],"longitudinal":[40,56,153,169],"changes":[41,57],"letter":[43],"fluency,":[44],"a":[45,159,194],"frontally":[46,61,109],"sensitive":[47,112],"task":[48],"(Caselli":[49],"2009).":[52],"We":[53],"therefore":[54],"compared":[55,178],"on":[58,173,252,271,289,303,327],"additional":[59],"age-sensitive":[60],"mediated":[62,110],"tasks":[63,111],"NC":[70,192,270,302],"identify":[72],"cognitive":[73],"correlates":[74],"of":[75,82,155,171,184,186,227,237,248,267,282,349],"frontal":[76,258,291],"deposition.":[78],"Cognitively":[79],"residents":[81],"Maricopa":[83],"County":[84],"age":[85,156,172,222,249],"21":[86],"years":[87,99,226],"older":[89],"(the":[90],"Arizona":[91],"cohort)":[93],"had":[94,263,297],"neuropsychological":[95],"testing":[96],"every":[97],"two":[98],"that":[100,162],"included":[101],"the":[102,152,165,179,182,208,272,283,304,339,346],"Auditory":[103,130],"Verbal":[104],"Learning":[105],"Test":[106],"(AVLT)":[107],"three":[114],"subdomains:":[115],"psychomotor":[116,364],"speed":[117],"(controlled":[118],"oral":[119],"word":[120],"association;":[121],"WAIS-R":[122,140,319,328],"digit":[123],"symbol":[124],"substitution":[125],"[DSS]),":[126],"working":[127,362],"memory":[128,363],"(Paced":[129],"Serial":[131],"Attention":[132],"Task":[133],"[PASAT]":[134],"2":[135,310],"3":[137,241,257,305],"second":[138,314],"versions;":[139],"mental":[141,329],"arithmetic),":[142],"problem":[144],"solving":[145],"(Wisconsin":[146],"Card":[147],"Sorting":[148],"Test).":[149],"To":[150],"isolate":[151],"effect":[154,285],"used":[158],"statistical":[160],"model":[161],"simultaneously":[163],"modeled":[164],"cross":[166],"sectional":[167],"effects":[170,247,335,357],"each":[174],"test":[175],"score":[176],"acceleration":[180,266],"rate":[183],"decline":[185,268,300,350],"scores":[187],"for":[188,338],"using":[193],"quadratic":[195,244],"mixed-model":[196],"approach.":[197],"71":[198],"homozygotes":[200],"(HMZ),":[201],"194":[202],"heterozygotes":[204],"(HTZ,":[205],"all":[206,256],"e3/4":[209],"genotype),":[210],"356":[212],"did":[216],"not":[217,287],"differ":[218],"significantly":[219,264],"mean":[221],"(56":[223],"\u00b1":[224,230,240],"11),":[225],"education":[228],"(16":[229],"2),":[231],"gender":[232],"(70%":[233],"women),":[234],"duration":[236],"followup":[238],"(6":[239],"years).":[242],"Significant":[243],"linear":[246,299],"were":[250,336,358],"seen":[251,337],"some":[253],"tests":[254],"subdomains.":[259],"greater":[265,298],"than":[269,301],"AVLT":[273,340],"(p":[274,306,311,321],"=":[275,307,312,322],".04)":[276],"as":[277,316,318],"previously":[278],"found.":[279],"Statistical":[280],"significance":[281],"same":[284],"was":[286],"achieved":[288],"any":[290],"test,":[292],"although":[293],".02)":[308],".06)":[313],"PASAT":[315],"well":[317],"DSS":[320],".01);":[323],"HMZ":[324],"additionally":[325],"declined":[326],"arithmetic.":[330],"gene":[333],"dose":[334],"PASAT-2":[342],"second.":[343],"Memory":[344],"remained":[345],"primary":[347],"area":[348],"presymptomatic":[352],"carriers.":[355],"Frontal":[356],"milder":[359],"involved":[361],"speed.":[365]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}