{"id":"https://openalex.org/W2016369709","doi":"https://doi.org/10.1097/meg.0b013e328306a3a2","title":"Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis","display_name":"Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis","publication_year":2009,"publication_date":"2009-05-21","ids":{"openalex":"https://openalex.org/W2016369709","doi":"https://doi.org/10.1097/meg.0b013e328306a3a2","mag":"2016369709","pmid":"https://pubmed.ncbi.nlm.nih.gov/19445043"},"language":"en","primary_location":{"id":"doi:10.1097/meg.0b013e328306a3a2","doi":"https://doi.org/10.1097/meg.0b013e328306a3a2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/meg.0b013e328306a3a2","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016369709"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090772202","display_name":"Imad Matouk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Imad J. Matouk","raw_affiliation_strings":["Department of Biology, Science and Technology, Alquds Abu-Dis University, Jerusalem, Israel. imatook@cc.huji.ac.il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Technology, Alquds Abu-Dis University, Jerusalem, Israel. imatook@cc.huji.ac.il","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032440300","display_name":"Ibrahim Abbasi","orcid":"https://orcid.org/0009-0004-2098-1245","observed_orcids":["https://orcid.org/0009-0004-2098-1245","https://orcid.org/0000-0002-6753-4344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ibrahim Abbasi","raw_affiliation_strings":["Department of Biology, Science and Technology, Alquds Abu-Dis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Technology, Alquds Abu-Dis University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005830467","display_name":"Abraham Hochberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Abraham Hochberg","raw_affiliation_strings":["Department of Biological Chemistry, Alexander Silberman Institute of life Science, Hebrew University of Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Alexander Silberman Institute of life Science, Hebrew University of Jerusalem","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090206769","display_name":"Eithan Galun","orcid":"https://orcid.org/0000-0002-6243-6702","observed_orcids":["https://orcid.org/0000-0002-6243-6702"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eithan Galun","raw_affiliation_strings":["Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111678967","display_name":"H. Dweik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan Dweik","raw_affiliation_strings":["Department of Biology, Science and Technology, Alquds Abu-Dis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Technology, Alquds Abu-Dis University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009061776","display_name":"Mutaz Akkawi","orcid":"https://orcid.org/0000-0002-0351-9698","observed_orcids":["https://orcid.org/0000-0002-0351-9698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mutaz Akkawi","raw_affiliation_strings":["Department of Biology, Science and Technology, Alquds Abu-Dis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Science and Technology, Alquds Abu-Dis University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090772202"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1205,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.87463557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"21","issue":"6","first_page":"688","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9430000185966492},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6919999718666077},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.49000000953674316},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.5350000262260437},{"id":"https://openalex.org/keywords/colorectal-cancer-cell-lines","display_name":"colorectal cancer cell lines","score":0.6759999990463257},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6820606589317322},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.6483508944511414},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5776307582855225},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5666284561157227},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5365310907363892},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5162063241004944},{"id":"https://openalex.org/C179255354","wikidata":"https://www.wikidata.org/wiki/Q284416","display_name":"Small nucleolar RNA","level":5,"score":0.4917290508747101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4880932569503784},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.48087838292121887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4239968955516815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37119317054748535},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.35815879702568054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33802804350852966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1894027292728424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18889182806015015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/meg.0b013e328306a3a2","doi":"https://doi.org/10.1097/meg.0b013e328306a3a2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/meg.0b013e328306a3a2","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},{"id":"pmid:19445043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19445043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9501000046730042}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1988871238","https://openalex.org/W2030120875","https://openalex.org/W2045844532","https://openalex.org/W2049536473","https://openalex.org/W2062290101","https://openalex.org/W2084122313","https://openalex.org/W2135810600","https://openalex.org/W2153525556","https://openalex.org/W2436604251","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2153525556","https://openalex.org/W3023732071","https://openalex.org/W2506702259","https://openalex.org/W2910337696","https://openalex.org/W2541879261","https://openalex.org/W2760015231","https://openalex.org/W3159787045","https://openalex.org/W2347980327","https://openalex.org/W2624912759","https://openalex.org/W4380030046"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"highly":[2],"upregulated":[3,205],"in":[4,32,38,50,58,105,121,127,156,167,177,187,206],"liver":[5,70],"cancer":[6],"(HULC)":[7],"gene":[8],"transcribes":[9],"to":[10,67,100,142,147,215,236,240,246],"an":[11,151],"mRNA-like":[12],"noncoding":[13],"RNA":[14,18],"(ncRNA)":[15],"by":[16,23],"the":[17,33,45,69,72,77,114,134,143,158,178,247],"polymerase":[19],"II":[20],"and":[21,26,57,108,185,192],"processed":[22],"capping,":[24],"splicing":[25],"polyadenylation.":[27],"It":[28],"is":[29,87,98,118,174,204,233],"specifically":[30],"expressed":[31,120,176],"hepatocytes":[34],"with":[35,113,163],"striking":[36],"upregulation":[37,152],"hepatocellular":[39,208],"carcinoma":[40,84,181,209],"(HCC).":[41],"OBJECTIVES:":[42],"To":[43],"study":[44,106],"expression":[46,104,166,232],"levels":[47],"of":[48,83,153,170,180,189,195],"HULC":[49,90,103,117,154,173,202,231],"normal":[51,129,190],"colorectal":[52,55,63,123,138,242],"samples,":[53],"primary":[54,122],"carcinomas":[56,64,124,139,243],"secondary":[59],"tumors":[60],"formed":[61],"from":[62,76],"that":[65,140,201,219,230,244],"metastasize":[66,141,245],"either":[68],"or":[71],"lymph":[73,148],"nodes,":[74],"taken":[75],"same":[78],"patients.":[79],"Also":[80],"a":[81,164],"panel":[82],"cell":[85,109,182,210],"lines":[86,183,211,218],"tested":[88,160,184],"for":[89,102,133],"expression.":[91],"BASIC":[92],"METHODS:":[93],"Semiquantitative":[94],"reverse":[95],"transcriptase-PCR":[96],"technique":[97],"used":[99],"detect":[101],"specimens":[107],"lines.":[110],"RESULTS:":[111],"Consistent":[112],"previous":[115],"report,":[116],"neither":[119],"samples":[125,159,188],"nor":[126],"their":[128,216],"counterparts.":[130],"We":[131,198],"show":[132,200],"first":[135],"time":[136],"those":[137,241],"livers":[144],"but":[145,238],"not":[146,175,221,234],"nodes":[149],"experience":[150],"ncRNA":[155,203],"all":[157],"(n=":[161],"8),":[162],"strong-to-moderate":[165],"six":[168],"out":[169],"eight.":[171],"Moreover":[172],"majority":[179],"also":[186,199,239],"bladder":[191,193],"cancers":[194],"various":[196],"grades.":[197],"two":[207],"producing":[212],"HBV":[213],"relevant":[214],"parental":[217],"do":[220],"produce":[222],"HBV.":[223],"CONCLUSION:":[224],"Our":[225],"results":[226],"presented":[227],"here":[228],"indicate":[229],"confined":[235],"HCC,":[237],"liver.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
