{"id":"https://openalex.org/W2016369535","doi":"https://doi.org/10.1371/journal.pone.0075589","title":"Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody","display_name":"Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody","publication_year":2013,"publication_date":"2013-09-23","ids":{"openalex":"https://openalex.org/W2016369535","doi":"https://doi.org/10.1371/journal.pone.0075589","mag":"2016369535","pmid":"https://pubmed.ncbi.nlm.nih.gov/24086580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3781095"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0075589","doi":"https://doi.org/10.1371/journal.pone.0075589","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075589","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075589&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075589&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China ; University of Chinese Academy of Sciences, Beijing, China","Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China ; University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101768782","display_name":"Yanran He","orcid":"https://orcid.org/0000-0002-5814-5734","observed_orcids":["https://orcid.org/0000-0002-5814-5734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanran He","raw_affiliation_strings":["University of Chinese Agriculture, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Agriculture, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086499502","display_name":"Ge Zhang","orcid":"https://orcid.org/0000-0002-6377-7760","observed_orcids":["https://orcid.org/0000-0002-6377-7760"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Zhang","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101650743","display_name":"Juan Ma","orcid":"https://orcid.org/0000-0002-6223-3761","observed_orcids":["https://orcid.org/0000-0002-6223-3761"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Ma","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047099887","display_name":"Changzhen Liu","orcid":"https://orcid.org/0000-0002-9240-5448","observed_orcids":["https://orcid.org/0000-0002-9240-5448"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changzhen Liu","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018126853","display_name":"Wen Zhi He","orcid":"https://orcid.org/0000-0001-8749-1022","observed_orcids":["https://orcid.org/0000-0001-8749-1022"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen He","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","Hebei Key Laboratory of Medical Biotechnology, Hebei Medical University, Shijiazhuang, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"Hebei Key Laboratory of Medical Biotechnology, Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113554803","display_name":"Huamin Han","orcid":"https://orcid.org/0009-0006-7500-5422","observed_orcids":["https://orcid.org/0009-0006-7500-5422"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huamin Han","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045151834","display_name":"Bhargavi M. Boruah","orcid":"https://orcid.org/0000-0002-3645-785X","observed_orcids":["https://orcid.org/0000-0002-3645-785X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bhargavi M. Boruah","raw_affiliation_strings":["Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100757015","display_name":"Bin Gao","orcid":"https://orcid.org/0000-0002-0505-2972","observed_orcids":["https://orcid.org/0000-0002-0505-2972"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Gao","raw_affiliation_strings":["China-Japan Joint Laboratory of Molecular Immunology and Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Joint Laboratory of Molecular Immunology and Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100757015"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.0334,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75462546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"e75589","last_page":"e75589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/colo-205-cells","display_name":"COLO 205 cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5289999842643738},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6796796917915344},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.6423998475074768},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.579525887966156},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5449392795562744},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5200942754745483},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5122358202934265},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4708537459373474},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4473879039287567},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4122297465801239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4073707163333893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4044072926044464},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.28494489192962646},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.21823498606681824},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17539307475090027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09706321358680725},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.0751708447933197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0075589","doi":"https://doi.org/10.1371/journal.pone.0075589","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075589","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075589&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2780777","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3781095","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3781095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3781095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24086580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24086580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.927.9089","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.927.9089","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://journals.plos.org/plosone/article/asset?id%3D10.1371/journal.pone.0075589.PDF","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c2d1ead6b2f6499493d83c476c34170d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c2d1ead6b2f6499493d83c476c34170d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e75589 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0075589","doi":"https://doi.org/10.1371/journal.pone.0075589","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075589","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075589&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1418026852","display_name":null,"funder_award_id":"30771953","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5296298262","display_name":null,"funder_award_id":"81021003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6639163808","display_name":"\u9ad8\u4eb2\u5408\u529bRANK\u7a81\u53d8\u4f53\u9632\u6cbb\u96cc\u5b55\u6fc0\u7d20\u66ff\u4ee3\u7597\u6cd5\u6240\u81f4\u4e73\u817a\u764c\u7684\u7814\u7a76","funder_award_id":"31170829","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G678192303","display_name":null,"funder_award_id":"2013CB531502","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016369535.pdf","grobid_xml":"https://content.openalex.org/works/W2016369535.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W201357455","https://openalex.org/W211277864","https://openalex.org/W1965205681","https://openalex.org/W1971242419","https://openalex.org/W1980873645","https://openalex.org/W1992319616","https://openalex.org/W2006174096","https://openalex.org/W2025041034","https://openalex.org/W2025629542","https://openalex.org/W2027268124","https://openalex.org/W2065300548","https://openalex.org/W2068354573","https://openalex.org/W2071843728","https://openalex.org/W2075901113","https://openalex.org/W2083483697","https://openalex.org/W2085604356","https://openalex.org/W2094945699","https://openalex.org/W2095156669","https://openalex.org/W2116295027","https://openalex.org/W2118371851","https://openalex.org/W2121160430","https://openalex.org/W2128402413","https://openalex.org/W2139538447","https://openalex.org/W2141393790","https://openalex.org/W2153024287","https://openalex.org/W2154776646","https://openalex.org/W2161300954","https://openalex.org/W2225363868","https://openalex.org/W2732122454","https://openalex.org/W2912894184","https://openalex.org/W4236858784"],"related_works":["https://openalex.org/W3214241682","https://openalex.org/W3178369229","https://openalex.org/W2343904215","https://openalex.org/W2110466399","https://openalex.org/W2095381447","https://openalex.org/W2897958605","https://openalex.org/W2090810974","https://openalex.org/W2258179564","https://openalex.org/W2193743718","https://openalex.org/W1489967151"],"abstract_inverted_index":{"To":[0],"exploit":[1],"the":[2,15,118],"biological":[3],"and":[4,13,67,105],"pharmacological":[5],"properties":[6],"of":[7,18,75],"immunoglobulin":[8],"constant":[9],"domain":[10],"Fc":[11,38],"fragment":[12,25,39],"increase":[14],"killing":[16],"efficacy":[17],"T":[19,77,95],"cells,":[20],"a":[21,36],"single":[22],"chain":[23],"variable":[24],"specific":[26],"to":[27,79,93,97],"CD3":[28],"was":[29,59,86,91,114],"fused":[30],"with":[31,40],"Fcab":[32],"(Fc":[33],"antigen":[34],"binding),":[35],"mutant":[37],"specificity":[41],"against":[42],"Human":[43],"epidermal":[44],"growth":[45],"factor":[46],"receptor":[47],"2":[48],"(HER2)":[49],"developed":[50],"by":[51,61,69],"F-star.":[52],"The":[53],"bispecific":[54],"fusion":[55],"named":[56],"as":[57],"FcabCD3":[58,90,113],"expressed":[60],"transient":[62],"transfection":[63],"in":[64,88,116],"HEK-293T":[65],"cells":[66,78,96],"purified":[68],"affinity":[70],"chromatography.":[71],"Specific":[72],"cytolytic":[73],"activity":[74],"retargeted":[76],"kill":[80,98],"HER2":[81,106],"positive":[82],"SKBR3":[83],"cell":[84,103,110],"line":[85,104],"evaluated":[87],"vitro.":[89],"able":[92],"retarget":[94],"both":[99],"Herceptin":[100],"insensitive":[101],"Colo205-luc":[102],"low":[107],"expression":[108],"MDA-MB-231-luc":[109],"line.":[111],"Furthermore,":[112],"effective":[115],"eliminating":[117],"Colo205":[119],"tumor":[120],"established":[121],"on":[122],"BALB/c":[123],"nu/nu":[124],"mice.":[125]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
