{"id":"https://openalex.org/W2016367750","doi":"https://doi.org/10.1902/jop.2008.070518","title":"Tissue\u2010Engineered Cultured Periosteum Used With Platelet\u2010Rich Plasma and Hydroxyapatite in Treating Human Osseous Defects","display_name":"Tissue\u2010Engineered Cultured Periosteum Used With Platelet\u2010Rich Plasma and Hydroxyapatite in Treating Human Osseous Defects","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2016367750","doi":"https://doi.org/10.1902/jop.2008.070518","mag":"2016367750","pmid":"https://pubmed.ncbi.nlm.nih.gov/18454659"},"language":"en","primary_location":{"id":"doi:10.1902/jop.2008.070518","doi":"https://doi.org/10.1902/jop.2008.070518","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2008.070518","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041064950","display_name":"\u304b\u306e\u5b50 \u5c71\u5bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanoko Yamamiya","raw_affiliation_strings":["Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, 52374 Chuo-ku, Gakkocho-dori 2-bancho, Niigata, Japan","Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, 52374 Chuo-ku, Gakkocho-dori 2-bancho, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102400751","display_name":"Kazuhiro Okuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiro Okuda","raw_affiliation_strings":["Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089698010","display_name":"Tomoyuki Kawase","orcid":"https://orcid.org/0000-0003-4160-396X","observed_orcids":["https://orcid.org/0000-0003-4160-396X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Kawase","raw_affiliation_strings":["Division of Pharmacology and Oral Bioengineering, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Oral Bioengineering, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109251929","display_name":"Ken\u2010ichiro Hata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273939","display_name":"Japan Tissue Engineering Co., Ltd. (Japan)","ror":"https://ror.org/00r4g4w23","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405273939"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken\u2010ichiro Hata","raw_affiliation_strings":["Japan Tissue Engineering, Gamagori, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Tissue Engineering, Gamagori, Aichi, Japan","institution_ids":["https://openalex.org/I4405273939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052461059","display_name":"Larry F. Wolff","orcid":"https://orcid.org/0000-0003-1448-5523","observed_orcids":["https://orcid.org/0000-0003-1448-5523"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry F. Wolff","raw_affiliation_strings":["Division of Periodontology, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005447574","display_name":"Hiromasa Yoshie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa Yoshie","raw_affiliation_strings":["Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102400751"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":6.5159,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.96962406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"79","issue":"5","first_page":"811","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.984000027179718},{"id":"https://openalex.org/keywords/hydroxyapatite-granules","display_name":"hydroxyapatite granules","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/clinical-attachment-gain","display_name":"clinical attachment level gain","score":0.8230000138282776},{"id":"https://openalex.org/keywords/osteogenic-cells","display_name":"osteogenic cells","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.830411434173584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8211578726768494},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.8136610984802246},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.741207480430603},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.6546534895896912},{"id":"https://openalex.org/C2777968807","wikidata":"https://www.wikidata.org/wiki/Q4925923","display_name":"Bleeding on probing","level":3,"score":0.5671946406364441},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.5437440276145935},{"id":"https://openalex.org/C61260549","wikidata":"https://www.wikidata.org/wiki/Q5133813","display_name":"Clinical attachment loss","level":3,"score":0.5071413516998291},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.4918687343597412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3575519919395447},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.35322076082229614},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24273234605789185}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010521","descriptor_name":"Periosteum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018786","descriptor_name":"Bone Substitutes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053657","descriptor_name":"Platelet-Rich Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1902/jop.2008.070518","doi":"https://doi.org/10.1902/jop.2008.070518","is_oa":false,"landing_page_url":"https://doi.org/10.1902/jop.2008.070518","pdf_url":null,"source":{"id":"https://openalex.org/S58498366","display_name":"Journal of Periodontology","issn_l":"0022-3492","issn":["0022-3492","1049-8885","1943-3670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontology","raw_type":"journal-article"},{"id":"pmid:18454659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18454659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontology","raw_type":"Journal Article"},{"id":"mag:2275726500","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000498575","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3039481265","display_name":"Tissue engineered periodontal regeneration using human autologous derived cells","funder_award_id":"17390558","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W3087809","https://openalex.org/W20451157","https://openalex.org/W55506304","https://openalex.org/W153721731","https://openalex.org/W1966446917","https://openalex.org/W1969758477","https://openalex.org/W1981027052","https://openalex.org/W2004020876","https://openalex.org/W2005919062","https://openalex.org/W2011161158","https://openalex.org/W2013172265","https://openalex.org/W2021792184","https://openalex.org/W2028747433","https://openalex.org/W2063653505","https://openalex.org/W2070348874","https://openalex.org/W2078877230","https://openalex.org/W2094882400","https://openalex.org/W2107228383","https://openalex.org/W2117081589","https://openalex.org/W2121985684","https://openalex.org/W2141333789","https://openalex.org/W2153389583","https://openalex.org/W4317564320"],"related_works":["https://openalex.org/W153721731","https://openalex.org/W1970384243","https://openalex.org/W2070348874","https://openalex.org/W1968908733","https://openalex.org/W2514228460","https://openalex.org/W1970084171","https://openalex.org/W2468938031","https://openalex.org/W2810658345","https://openalex.org/W4294100402","https://openalex.org/W2129128425"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,67],"aim":[2],"of":[3,15,35,42,208,238],"the":[4,12,40,73,84,99,107,123,141,144,236,242],"present":[5],"controlled":[6],"clinical":[7,13,131,155,220,233],"study":[8],"was":[9],"to":[10,32,72,105,140,200,215,230],"compare":[11],"response":[14],"human":[16,43],"cultured":[17],"periosteum":[18],"(HCP)":[19],"sheets":[20,77],"in":[21,39,53,64,116,122,154,222,241],"combination":[22,207],"with":[23,59,79,88,202,205],"platelet-rich":[24],"plasma":[25],"(PRP)":[26],"and":[27,37,81,91,98,134,182,212],"porous":[28],"hydroxyapatite":[29],"(HA)":[30],"granules":[31],"a":[33,148,206,216],"mixture":[34],"PRP":[36,80,201],"HA":[38,213],"treatment":[41,113,204],"infrabony":[44,50,136,184,223],"periodontal":[45,224],"defects.":[46,225],"METHODS:":[47],"Thirty":[48],"interproximal":[49],"osseous":[51],"defects":[52],"30":[54],"healthy,":[55],"non-smoking":[56],"subjects":[57,68],"diagnosed":[58],"chronic":[60],"periodontitis":[61],"were":[62,69,94],"included":[63],"this":[65],"study.":[66],"randomly":[70],"assigned":[71],"test":[74,145],"group":[75,86,146],"(HCP":[76],"combined":[78],"HA)":[82],"or":[83],"control":[85,142],"(PRP":[87],"HA).":[89],"Clinical":[90],"radiographic":[92,135,183],"measurements":[93],"made":[95],"at":[96],"baseline":[97],"12-month":[100,108],"post-surgical":[101],"evaluation.":[102],"RESULTS:":[103],"Compared":[104,139,199],"baseline,":[106],"results":[109,234],"indicated":[110],"that":[111],"both":[112],"modalities":[114],"resulted":[115],"statistically":[117,149],"significant":[118],"changes":[119],"(P":[120],"<0.01)":[121],"gingival":[124],"index,":[125],"bleeding":[126],"on":[127],"probing,":[128],"probing":[129],"depth,":[130],"attachment":[132,156,171],"level,":[133],"defect":[137,185],"depth.":[138],"group,":[143],"exhibited":[147],"significantly":[150,217],"more":[151,218],"favorable":[152,219,232],"change":[153],"gain":[157,172],"(3.9":[158],"+/-":[159,164,174,178,188,193],"1.6":[160],"mm":[161,190],"versus":[162,176,191],"2.7":[163],"1.3":[165],"mm;":[166,195],"P":[167,180,196],"<0.05),":[168,181],"vertical":[169],"relative":[170],"(83.5%":[173],"31.7%":[175],"55.0%":[177],"21.9%;":[179],"fill":[186],"(4.9":[187],"1.2":[189],"3.2":[192],"1.1":[194],"<0.01).":[197],"CONCLUSIONS:":[198],"HA,":[203],"HCP":[209,243],"sheets,":[210,244],"PRP,":[211],"led":[214],"improvement":[221],"A":[226],"factor":[227],"likely":[228],"contributing":[229],"these":[231],"is":[235],"presence":[237],"osteogenic":[239],"cells":[240],"which":[245],"provided":[246],"greater":[247],"regeneration":[248],"potential.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}