{"id":"https://openalex.org/W2016367481","doi":"https://doi.org/10.3390/ijerph9072444","title":"Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor","display_name":"Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor","publication_year":2012,"publication_date":"2012-07-10","ids":{"openalex":"https://openalex.org/W2016367481","doi":"https://doi.org/10.3390/ijerph9072444","mag":"2016367481","pmid":"https://pubmed.ncbi.nlm.nih.gov/22851953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3407914"},"language":"en","primary_location":{"id":"doi:10.3390/ijerph9072444","doi":"https://doi.org/10.3390/ijerph9072444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph9072444","pdf_url":"https://www.mdpi.com/1660-4601/9/7/2444/pdf?version=1403139755","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-4601/9/7/2444/pdf?version=1403139755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066455212","display_name":"Sachiko Ezoe","orcid":"https://orcid.org/0000-0003-2899-9648","observed_orcids":["https://orcid.org/0000-0003-2899-9648"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sachiko Ezoe","raw_affiliation_strings":["Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066455212"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":2500,"currency":"CHF","value_usd":3016},"apc_paid":{"value":2500,"currency":"CHF","value_usd":3016},"fwci":1.3989,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.80060554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"7","first_page":"2444","last_page":"2453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.2345999926328659,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.20340000092983246,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9580000042915344},{"id":"https://openalex.org/keywords/secondary-leukemia","display_name":"secondary leukemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chromosome-11q23","display_name":"chromosome 11q23","score":0.9390000104904175},{"id":"https://openalex.org/keywords/therapy-related-leukemia","display_name":"therapy-related leukemia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/teniposide","display_name":"teniposide","score":0.9750000238418579},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.36899998784065247},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.9339241981506348},{"id":"https://openalex.org/C2778707968","wikidata":"https://www.wikidata.org/wiki/Q417555","display_name":"Teniposide","level":4,"score":0.7783406376838684},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.7403650283813477},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.5826290249824524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5705960988998413},{"id":"https://openalex.org/C2778616834","wikidata":"https://www.wikidata.org/wiki/Q281044","display_name":"Topoisomerase inhibitor","level":4,"score":0.48667842149734497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47571948170661926},{"id":"https://openalex.org/C2778143360","wikidata":"https://www.wikidata.org/wiki/Q421193","display_name":"Podophyllotoxin","level":2,"score":0.4606907367706299},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42061981558799744},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3952869176864624},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3477572798728943},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3361184597015381},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3033882677555084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2808241844177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27907323837280273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1284552812576294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12461355328559875},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09469631314277649},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijerph9072444","doi":"https://doi.org/10.3390/ijerph9072444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph9072444","pdf_url":"https://www.mdpi.com/1660-4601/9/7/2444/pdf?version=1403139755","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3407914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3407914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Environ Res Public Health","raw_type":"Text"},{"id":"pmid:22851953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22851953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of environmental research and public health","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:gam:jijerp:v:9:y:2012:i:7:p:2444-2453:d:18800","doi":null,"is_oa":false,"landing_page_url":"https://www.mdpi.com/1660-4601/9/7/2444/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:79f39578184c48259de199e27f4609fe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/79f39578184c48259de199e27f4609fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Environmental Research and Public Health, Vol 9, Iss 7, Pp 2444-2453 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijerph9072444","doi":"https://doi.org/10.3390/ijerph9072444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijerph9072444","pdf_url":"https://www.mdpi.com/1660-4601/9/7/2444/pdf?version=1403139755","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016367481.pdf","grobid_xml":"https://content.openalex.org/works/W2016367481.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W33382804","https://openalex.org/W147492690","https://openalex.org/W203170764","https://openalex.org/W1487803311","https://openalex.org/W1632595063","https://openalex.org/W1635524817","https://openalex.org/W1833467461","https://openalex.org/W1898563950","https://openalex.org/W1963716328","https://openalex.org/W1966444756","https://openalex.org/W1967139222","https://openalex.org/W1968048144","https://openalex.org/W1984183735","https://openalex.org/W1987814047","https://openalex.org/W1987933754","https://openalex.org/W1988377387","https://openalex.org/W2008543889","https://openalex.org/W2008601218","https://openalex.org/W2008935189","https://openalex.org/W2009980373","https://openalex.org/W2016644651","https://openalex.org/W2024254896","https://openalex.org/W2031454576","https://openalex.org/W2033137304","https://openalex.org/W2036489020","https://openalex.org/W2041594420","https://openalex.org/W2046547913","https://openalex.org/W2046750894","https://openalex.org/W2047039095","https://openalex.org/W2048517151","https://openalex.org/W2051907464","https://openalex.org/W2055952888","https://openalex.org/W2059660444","https://openalex.org/W2077982832","https://openalex.org/W2078602364","https://openalex.org/W2087847676","https://openalex.org/W2096450527","https://openalex.org/W2097006389","https://openalex.org/W2108819177","https://openalex.org/W2111484240","https://openalex.org/W2111772438","https://openalex.org/W2119547213","https://openalex.org/W2127999710","https://openalex.org/W2147872390","https://openalex.org/W2154218976","https://openalex.org/W2155405526","https://openalex.org/W2159435444","https://openalex.org/W2159809038","https://openalex.org/W2169857347","https://openalex.org/W2267487266","https://openalex.org/W2333611917","https://openalex.org/W2409952447","https://openalex.org/W2418076436","https://openalex.org/W2992983818","https://openalex.org/W3113030787","https://openalex.org/W6639841313","https://openalex.org/W6714924457"],"related_works":["https://openalex.org/W7099855327","https://openalex.org/W2131724975","https://openalex.org/W3180099903","https://openalex.org/W2418626462","https://openalex.org/W2401957154","https://openalex.org/W2556368263","https://openalex.org/W2095635523","https://openalex.org/W1963716328","https://openalex.org/W2012353841","https://openalex.org/W2136868722"],"abstract_inverted_index":{"Etoposide":[0],"is":[1,6,71,78,95],"an":[2],"anticancer":[3],"agent,":[4],"which":[5,70],"successfully":[7],"and":[8,20,29,55,110,126,147],"extensively":[9],"used":[10],"in":[11,18,27,86],"treatments":[12],"for":[13,46,81,149],"various":[14],"types":[15],"of":[16,33,43,96,103,107,124,140],"cancers":[17],"children":[19],"adults.":[21],"However,":[22],"due":[23],"to":[24,99,120],"the":[25,40,61,87,104,111,114,137],"increases":[26],"survival":[28],"overall":[30],"cure":[31],"rate":[32],"cancer":[34],"patients,":[35],"interest":[36],"has":[37],"arisen":[38],"on":[39,67],"potential":[41],"risk":[42],"this":[44,118],"agent":[45,119],"therapy-related":[47],"secondary":[48,74,92,142],"leukemia.":[49,75,152],"Topoisomerase":[50],"II":[51],"inhibitors,":[52],"including":[53,90],"etoposide":[54],"teniposide,":[56],"frequently":[57],"cause":[58],"rearrangements":[59,85],"involving":[60],"mixed":[62],"lineage":[63],"leukemia":[64],"(MLL)":[65],"gene":[66],"chromosome":[68],"11q23,":[69],"associated":[72,83],"with":[73,84],"The":[76],"prognosis":[77],"extremely":[79],"poor":[80],"leukemias":[82],"MLL":[88],"gene,":[89],"etoposide-related":[91,141],"leukemias.":[93],"It":[94],"great":[97],"importance":[98],"gain":[100],"precise":[101],"knowledge":[102,135],"clinical":[105,138],"aspects":[106,139],"these":[108],"diseases":[109],"mechanism":[112],"underlying":[113],"leukemogenesis":[115],"induced":[116],"by":[117],"ensure":[121],"correct":[122],"assessments":[123],"current":[125,134],"future":[127],"therapy":[128],"strategies.":[129],"Here,":[130],"I":[131],"will":[132],"review":[133],"regarding":[136],"leukemia,":[143],"some":[144],"probable":[145],"mechanisms,":[146],"strategies":[148],"treating":[150],"etoposide-induced":[151]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
