{"id":"https://openalex.org/W2016363938","doi":"https://doi.org/10.1097/00007890-199605270-00008","title":"ACUTE GRAFT REJECTION OF HUMAN FETAL PANCREAS ALLOGRAFTS USING DONOR-SPECIFIC HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN THE SCID MOUSE1","display_name":"ACUTE GRAFT REJECTION OF HUMAN FETAL PANCREAS ALLOGRAFTS USING DONOR-SPECIFIC HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN THE SCID MOUSE1","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2016363938","doi":"https://doi.org/10.1097/00007890-199605270-00008","mag":"2016363938","pmid":"https://pubmed.ncbi.nlm.nih.gov/8633371"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199605270-00008","doi":"https://doi.org/10.1097/00007890-199605270-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199605270-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072175911","display_name":"Debra A. MacKenzie","orcid":"https://orcid.org/0000-0003-4243-6286","observed_orcids":["https://orcid.org/0000-0003-4243-6286"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra A. MacKenzie","raw_affiliation_strings":["Department of Surgery, University of Wisconsin, Madison, 53792, USA","* Abbreviations: GVHD, graft versus host disease","Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","HFP, human fetal pancreas","SCID, severe combined immunodeficiency","hu-PBL, human peripheral blood lymphocytes","hu-SPL, human splenocytes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Wisconsin, Madison, 53792, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"* Abbreviations: GVHD, graft versus host disease","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"]},{"raw_affiliation_string":"HFP, human fetal pancreas","institution_ids":[]},{"raw_affiliation_string":"SCID, severe combined immunodeficiency","institution_ids":[]},{"raw_affiliation_string":"hu-PBL, human peripheral blood lymphocytes","institution_ids":[]},{"raw_affiliation_string":"hu-SPL, human splenocytes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110004938","display_name":"HANS W. SOLLINGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans W. Sollinger","raw_affiliation_strings":["Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","* Abbreviations: GVHD, graft versus host disease","Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","HFP, human fetal pancreas","SCID, severe combined immunodeficiency","hu-PBL, human peripheral blood lymphocytes","hu-SPL, human splenocytes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"* Abbreviations: GVHD, graft versus host disease","institution_ids":[]},{"raw_affiliation_string":"Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"]},{"raw_affiliation_string":"HFP, human fetal pancreas","institution_ids":[]},{"raw_affiliation_string":"SCID, severe combined immunodeficiency","institution_ids":[]},{"raw_affiliation_string":"hu-PBL, human peripheral blood lymphocytes","institution_ids":[]},{"raw_affiliation_string":"hu-SPL, human splenocytes","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110119499","display_name":"Debra A. Hullett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debra A. Hullett","raw_affiliation_strings":["Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","to Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","* Abbreviations: GVHD, graft versus host disease","Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","HFP, human fetal pancreas","SCID, severe combined immunodeficiency","hu-PBL, human peripheral blood lymphocytes","hu-SPL, human splenocytes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"to Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"]},{"raw_affiliation_string":"* Abbreviations: GVHD, graft versus host disease","institution_ids":[]},{"raw_affiliation_string":"Dr. Debra A. Hullett, Department of Surgery, Room H4/749, University of Wisconsin Hospitals and Clinics, 600 Highland Ave., Madison WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"]},{"raw_affiliation_string":"HFP, human fetal pancreas","institution_ids":[]},{"raw_affiliation_string":"SCID, severe combined immunodeficiency","institution_ids":[]},{"raw_affiliation_string":"hu-PBL, human peripheral blood lymphocytes","institution_ids":[]},{"raw_affiliation_string":"hu-SPL, human splenocytes","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110119499"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"],"apc_list":null,"apc_paid":null,"fwci":1.6277,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83453594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"10","first_page":"1461","last_page":"1464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.14390000700950623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/scid-mouse-model","display_name":"SCID mouse model","score":0.8389999866485596},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chimerism","display_name":"chimerism","score":0.49399998784065247},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/graft-infiltrating-lymphocytes","display_name":"graft-infiltrating lymphocytes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6660012006759644},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5970626473426819},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5898864269256592},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5882605314254761},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5130592584609985},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.5015225410461426},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4968130886554718},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44805100560188293},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.339105486869812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21309593319892883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1579853892326355},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10895398259162903},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016035","descriptor_name":"Pancreas Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199605270-00008","doi":"https://doi.org/10.1097/00007890-199605270-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199605270-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:8633371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8633371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4049596384","display_name":"TRANSPLANTATION OF ENDOCRINE TISSUES","funder_award_id":"2r01dk035446-06a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4647114931","display_name":null,"funder_award_id":"HD 32173","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7350929442","display_name":null,"funder_award_id":"DK-35446","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1504810785","https://openalex.org/W1505145311","https://openalex.org/W1539377589","https://openalex.org/W1568631834","https://openalex.org/W1591916802","https://openalex.org/W1970103360","https://openalex.org/W1985529783","https://openalex.org/W1988746329","https://openalex.org/W1989877475","https://openalex.org/W2008288694","https://openalex.org/W2027792041","https://openalex.org/W2042784158","https://openalex.org/W2043743303","https://openalex.org/W2046560815","https://openalex.org/W2076835540","https://openalex.org/W2086822970"],"related_works":["https://openalex.org/W4313330990","https://openalex.org/W2113570579","https://openalex.org/W2414458700","https://openalex.org/W2090393151","https://openalex.org/W2076835540","https://openalex.org/W2156205670","https://openalex.org/W1985529783","https://openalex.org/W1504810785","https://openalex.org/W2007149825","https://openalex.org/W2047480864"],"abstract_inverted_index":{"Transplantation":[0],"of":[1,27,91,126,135,151,162,171,189,194,206,231],"human":[2,67,78,164,179],"fetal":[3],"pancreas":[4],"(HFP)":[5],"is":[6,20,83,218],"being":[7],"considered":[8],"as":[9,140,157,184],"a":[10,59,102,224],"potential":[11,48,199],"treatment":[12],"for":[13],"insulin-dependent":[14],"diabetes":[15],"mellitus":[16],"(IDDM).":[17],"Therefore,":[18],"it":[19,62],"necessary":[21],"to":[22,33,40,46,178,200,227,235],"have":[23],"an":[24,116,132,239],"experimental":[25],"model":[26,103,145,196,221],"HFP-specific":[28],"allograft":[29,41,68],"rejection":[30,69,82,134,175,241],"in":[31,44,73,104,117,131,153,167,213],"order":[32],"understand":[34],"all":[35],"the":[36,89,96,127,149,154,160,168,198,204,207,211,215,229],"fators":[37],"that":[38,66],"contribute":[39],"rejection,":[42],"and":[43,85,94,181],"which":[45,105,214],"test":[47,228],"immunomodulatory":[49,232],"protocols.":[50],"The":[51,192],"severe":[52],"combined":[53],"immunodeficient":[54],"(SCID)":[55],"mouse":[56],"provides":[57],"such":[58],"model.":[60],"Previously,":[61],"has":[63],"been":[64],"reported":[65],"can":[70,222],"be":[71],"observed":[72],"SCID":[74,106,155],"mice":[75,107],"engrafted":[76],"with":[77,111,121],"lymphocytes.":[79],"However,":[80],"graft":[81],"inconsistent":[84],"depends":[86],"on":[87,95],"both":[88],"number":[90],"lymphocytes":[92,113],"injected":[93,109],"activation":[97],"state.":[98],"Here,":[99],"we":[100],"describe":[101],"are":[108],"intraperitoneally":[110],"donor-specific":[112],"generated":[114],"by":[115,159,186],"vitro":[118],"culture":[119],"period":[120],"irradiated":[122],"donor":[123],"splenocytes.":[124],"Injection":[125],"donor-sensitized":[128],"PBL":[129],"results":[130],"acute":[133,240],"HFP":[136],"allografts":[137,237],"(as":[138],"early":[139],"4":[141],"days":[142],"post-transplant).":[143],"This":[144,220],"does":[146],"not":[147],"require":[148],"establishment":[150],"chimerism.":[152],"mice,":[156],"demonstrated":[158],"lack":[161],"detectable":[163],"CD45":[165],"cells":[166,209],"peripheral":[169],"blood":[170],"rejecting":[172],"mice.":[173],"Allograft":[174],"was":[176],"due":[177],"CD4+":[180],"CD8+":[182],"cells,":[183],"determined":[185],"immunohistochemical":[187],"analysis":[188],"graft-infiltrating":[190],"cells.":[191],"advantages":[193],"this":[195],"include":[197],"specifically":[201],"manipulate":[202],"either":[203],"phenotype":[205],"responding":[208,216],"or":[210],"mechanism":[212],"population":[217],"generated.":[219],"provide":[223],"rapid":[225],"method":[226],"efficacy":[230],"regimens":[233],"designed":[234],"protect":[236],"from":[238],"response.":[242]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
