{"id":"https://openalex.org/W2016353229","doi":"https://doi.org/10.1016/s0014-5793(99)00206-9","title":"Binding of neuronal ELAV\u2010like proteins to the uridine\u2010rich sequence in the 3\u2032\u2010untranslated region of tumor necrosis factor\u2010\u03b1 messenger RNA","display_name":"Binding of neuronal ELAV\u2010like proteins to the uridine\u2010rich sequence in the 3\u2032\u2010untranslated region of tumor necrosis factor\u2010\u03b1 messenger RNA","publication_year":1999,"publication_date":"1999-03-05","ids":{"openalex":"https://openalex.org/W2016353229","doi":"https://doi.org/10.1016/s0014-5793(99)00206-9","mag":"2016353229","pmid":"https://pubmed.ncbi.nlm.nih.gov/10100634"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(99)00206-9","doi":"https://doi.org/10.1016/s0014-5793(99)00206-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-5793(99)00206-9","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113566498","display_name":"Koichiro Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koichiro Sakai","raw_affiliation_strings":["Department of Neurology, Kanazawa Medical University, Ishikawa, Japan. ksakai@kanazawa-med.ac.jp","Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kanazawa Medical University, Ishikawa, Japan. ksakai@kanazawa-med.ac.jp","institution_ids":["https://openalex.org/I16568816"]},{"raw_affiliation_string":"Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-02, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073777734","display_name":"Yoko Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Kitagawa","raw_affiliation_strings":["Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-02, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083757237","display_name":"Genjiro Hirose","orcid":"https://orcid.org/0000-0003-2109-3050","observed_orcids":["https://orcid.org/0000-0003-2109-3050"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genjiro Hirose","raw_affiliation_strings":["Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-02, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-02, Japan","institution_ids":["https://openalex.org/I16568816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113566498"],"corresponding_institution_ids":["https://openalex.org/I16568816"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.7661,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.6576596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"446","issue":"1","first_page":"157","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mrna-binding-proteins","display_name":"mRNA-binding proteins","score":0.7480000257492065},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytokine-expression-regulation","display_name":"cytokine expression regulation","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7776862382888794},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.7312777042388916},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.703525185585022},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.6881017684936523},{"id":"https://openalex.org/C185622968","wikidata":"https://www.wikidata.org/wiki/Q4654967","display_name":"AU-rich element","level":5,"score":0.6671057343482971},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6227445602416992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6093366146087646},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6019896268844604},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.48413142561912537},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4375775158405304},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43549588322639465},{"id":"https://openalex.org/C178809742","wikidata":"https://www.wikidata.org/wiki/Q3455913","display_name":"Post-transcriptional regulation","level":4,"score":0.4287862181663513},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3399808406829834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22991034388542175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15273430943489075},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11811193823814392},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0990791916847229}],"mesh":[{"descriptor_ui":"D000067777","descriptor_name":"ELAV-Like Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-5793(99)00206-9","doi":"https://doi.org/10.1016/s0014-5793(99)00206-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-5793(99)00206-9","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:10100634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10100634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1553243256","https://openalex.org/W1562579211","https://openalex.org/W1573008071","https://openalex.org/W1600827637","https://openalex.org/W1606617874","https://openalex.org/W1634459475","https://openalex.org/W1982925662","https://openalex.org/W1986909326","https://openalex.org/W1987802477","https://openalex.org/W1987871624","https://openalex.org/W1988425964","https://openalex.org/W2004563262","https://openalex.org/W2013330436","https://openalex.org/W2020362649","https://openalex.org/W2024248428","https://openalex.org/W2025392129","https://openalex.org/W2045714098","https://openalex.org/W2060708740","https://openalex.org/W2063574627","https://openalex.org/W2082551528","https://openalex.org/W2083881390","https://openalex.org/W2089532702","https://openalex.org/W2099826413","https://openalex.org/W2116523120","https://openalex.org/W2122400789","https://openalex.org/W2122744980","https://openalex.org/W2145677005","https://openalex.org/W2148814680","https://openalex.org/W2150627157","https://openalex.org/W2151525922","https://openalex.org/W2160604432","https://openalex.org/W2163805309","https://openalex.org/W4211134699"],"related_works":["https://openalex.org/W2020362649","https://openalex.org/W2160604432","https://openalex.org/W2016776106","https://openalex.org/W7161939944","https://openalex.org/W1585193755","https://openalex.org/W2164909689","https://openalex.org/W7161981474","https://openalex.org/W2085126450","https://openalex.org/W1974066524","https://openalex.org/W2058435956"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor-alpha":[2],"(TNF-alpha)":[3],"is":[4,9,31],"a":[5,44],"proinflammatory":[6],"cytokine":[7],"that":[8,43,100,125],"involved":[10],"in":[11,23,33,53,66,72,82,101,141],"the":[12,24,51,54,63,70,73,83,90,115,118,126,137],"pathogenesis":[13],"of":[14,28,36,56,75,104,117,128,139],"several":[15],"human":[16,45],"CNS":[17],"disorders.":[18],"The":[19,59,78],"AU-rich":[20],"element":[21],"(ARE)":[22],"3'-untranslated":[25],"region":[26,81],"(UTR)":[27],"TNF-alpha":[29,57,76,79,112,140],"mRNA":[30],"implicated":[32],"post-transcriptional":[34],"control":[35],"TNF-alpha.":[37],"In":[38],"this":[39,97],"study,":[40],"we":[41],"showed":[42,99],"neuronal":[46,119,129,142],"ELAV-like":[47,120,130],"protein":[48,60,84],"binds":[49,61],"to":[50,62,86,89],"ARE":[52,71],"3'-UTR":[55,74],"mRNA.":[58,77],"uridine":[64],"stretch":[65],"AUUUA":[67],"pentanucleotides":[68],"inside":[69],"mRNA-binding":[80,94],"appears":[85],"be":[87,133],"identical":[88],"c-myc":[91],"and":[92],"IL-3":[93],"regions.":[95],"Moreover,":[96],"study":[98],"vitro":[102],"treatment":[103],"neuroblastoma":[105],"cells":[106],"with":[107,136],"interleukin-4":[108],"(IL-4),":[109],"which":[110],"inhibits":[111],"production,":[113],"reduced":[114],"expression":[116,127,138],"proteins.":[121],"These":[122],"results":[123],"suggest":[124],"proteins":[131],"may":[132],"closely":[134],"associated":[135],"cells.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}