{"id":"https://openalex.org/W2016342846","doi":"https://doi.org/10.1021/jm030099v","title":"Novel S-Substituted Aminoalkylamino Ethanethiols as Potential Antidotes against Sulfur Mustard Toxicity","display_name":"Novel S-Substituted Aminoalkylamino Ethanethiols as Potential Antidotes against Sulfur Mustard Toxicity","publication_year":2004,"publication_date":"2004-06-19","ids":{"openalex":"https://openalex.org/W2016342846","doi":"https://doi.org/10.1021/jm030099v","mag":"2016342846","pmid":"https://pubmed.ncbi.nlm.nih.gov/15239660"},"language":"en","primary_location":{"id":"doi:10.1021/jm030099v","doi":"https://doi.org/10.1021/jm030099v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm030099v","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109585762","display_name":"Uma Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uma Pathak","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159373","display_name":"Syed Kalbey Raza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed K. Raza","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108205936","display_name":"Abhay Kulkarni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. S. Kulkarni","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rajagopalan Vijayaraghvan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajagopalan Vijayaraghvan","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103575531","display_name":"Pravin Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pravin Kumar","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113579212","display_name":"D. K. Jaiswal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800900741","display_name":"Defence Research and Development Establishment","ror":"https://ror.org/04sm60f26","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1340206300","https://openalex.org/I2799351866","https://openalex.org/I2800900741","https://openalex.org/I4210150591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devendra K. Jaiswal","raw_affiliation_strings":["Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Research & Development Establishment, Jhansi Road, Gwalior-474 002, India","institution_ids":["https://openalex.org/I2800900741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800900741"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6144,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.64505387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"47","issue":"15","first_page":"3817","last_page":"3822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.296099990606308,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.296099990606308,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13304","display_name":"Synthesis and Reactivity of Sulfur-Containing Compounds","score":0.26420000195503235,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfur-mustard","display_name":"sulfur mustard","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antidotes","display_name":"antidotes","score":0.7239999771118164},{"id":"https://openalex.org/keywords/chemical-warfare-agents","display_name":"chemical warfare agents","score":0.7749999761581421},{"id":"https://openalex.org/keywords/thioethers","display_name":"thioethers","score":0.8569999933242798},{"id":"https://openalex.org/keywords/percutaneous-toxicity","display_name":"percutaneous toxicity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dermal-exposure","display_name":"dermal exposure","score":0.8209999799728394},{"id":"https://openalex.org/keywords/heterocyclic-substituents","display_name":"heterocyclic substituents","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9387612342834473},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7204174399375916},{"id":"https://openalex.org/C2780644109","wikidata":"https://www.wikidata.org/wiki/Q81166","display_name":"Sulfur mustard","level":3,"score":0.7087372541427612},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.5371935963630676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3834947347640991},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2978399991989136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002619","descriptor_name":"Chemical Warfare Agents","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009151","descriptor_name":"Mustard Gas","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm030099v","doi":"https://doi.org/10.1021/jm030099v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm030099v","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:15239660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15239660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W59056912","https://openalex.org/W1991837366","https://openalex.org/W1993157160","https://openalex.org/W1994476763","https://openalex.org/W1998231003","https://openalex.org/W2002753229","https://openalex.org/W2007884286","https://openalex.org/W2008710321","https://openalex.org/W2019769663","https://openalex.org/W2038951411","https://openalex.org/W2041518443","https://openalex.org/W2056618457","https://openalex.org/W2061405061","https://openalex.org/W2063690381","https://openalex.org/W2069036711","https://openalex.org/W2070022461","https://openalex.org/W2071848506","https://openalex.org/W2074900532","https://openalex.org/W2082764897","https://openalex.org/W2085313140","https://openalex.org/W2227718572","https://openalex.org/W2322337089","https://openalex.org/W2322405965","https://openalex.org/W2323057147","https://openalex.org/W2325061458","https://openalex.org/W2408244426"],"related_works":["https://openalex.org/W2049959729","https://openalex.org/W2002283777","https://openalex.org/W3138650570","https://openalex.org/W4385891674","https://openalex.org/W2265246976","https://openalex.org/W2316808987","https://openalex.org/W2346985973","https://openalex.org/W2938417994","https://openalex.org/W2315909578","https://openalex.org/W2049571040"],"abstract_inverted_index":{"Sulfur":[0],"mustard":[1,74],"(SM)":[2],"is":[3,14],"a":[4,22,30],"highly":[5],"toxic":[6],"chemical":[7],"warfare":[8],"agent.":[9],"A":[10,90],"satisfactory":[11],"treatment":[12],"regimen":[13],"not":[15],"yet":[16],"available":[17],"for":[18,24,62],"this":[19],"toxicant.":[20],"In":[21],"search":[23],"an":[25],"effective":[26],"antidote":[27],"against":[28,55,70],"SM,":[29],"series":[31],"of":[32,82,88,92],"novel":[33],"S-2(omega-aminoalkylamino)ethyl":[34],"alkyl/aryl":[35],"thioethers":[36],"[H(2)N(CH(2))(n)()NHCH(2)CH(2)SR],":[37],"where":[38],"R":[39],"=":[40],"alky,":[41],"alicyclic,":[42],"aryl,":[43],"and":[44,50],"heterocyclic":[45],"substituents,":[46],"have":[47],"been":[48],"designed":[49],"synthesized":[51],"as":[52],"candidate":[53],"antidotes":[54],"SM":[56],"toxicity.":[57],"These":[58],"compounds":[59,93],"were":[60],"screened":[61],"their":[63],"protective":[64],"efficacy":[65],"through":[66],"the":[67,80],"oral":[68],"route":[69],"dermally":[71],"applied":[72],"sulfur":[73],"in":[75],"female":[76],"mice":[77],"measured":[78],"on":[79],"basis":[81],"percent":[83],"survival":[84],"following":[85],"percutaneous":[86],"administration":[87],"SM.":[89],"number":[91],"demonstrated":[94],"significant":[95],"protection.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
