{"id":"https://openalex.org/W2016334712","doi":"https://doi.org/10.1056/nejm199601253340403","title":"Lack of Effect of Thyroxine in Patients with Graves' Hyperthyroidism Who Are Treated with an Antithyroid Drug","display_name":"Lack of Effect of Thyroxine in Patients with Graves' Hyperthyroidism Who Are Treated with an Antithyroid Drug","publication_year":1996,"publication_date":"1996-01-25","ids":{"openalex":"https://openalex.org/W2016334712","doi":"https://doi.org/10.1056/nejm199601253340403","mag":"2016334712","pmid":"https://pubmed.ncbi.nlm.nih.gov/8531998"},"language":"en","primary_location":{"id":"doi:10.1056/nejm199601253340403","doi":"https://doi.org/10.1056/nejm199601253340403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm199601253340403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058620102","display_name":"Bryan McIver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bryan McIver","raw_affiliation_strings":["Endocrine Clinic, Royal Infirmary, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Clinic, Royal Infirmary, Edinburgh, Scotland","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113136598","display_name":"P Rae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Rae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110026366","display_name":"Geoffrey J. Beckett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey Beckett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034166664","display_name":"Ewan Wilkinson","orcid":"https://orcid.org/0000-0002-2167-8756","observed_orcids":["https://orcid.org/0000-0002-2167-8756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewan Wilkinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ann Gold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Gold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109946858","display_name":"A D Toft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Toft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.7543,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.99227941,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"334","issue":"4","first_page":"220","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8529999852180481},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/carbimazole","display_name":"carbimazole","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hyperthyroidism-recurrence","display_name":"hyperthyroidism recurrence","score":0.8870000243186951},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.574999988079071},{"id":"https://openalex.org/keywords/serum-thyrotropin","display_name":"serum thyrotropin","score":0.800000011920929},{"id":"https://openalex.org/keywords/thyroid-hormone-withdrawal","display_name":"thyroid hormone withdrawal","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2779442721","wikidata":"https://www.wikidata.org/wiki/Q414013","display_name":"Carbimazole","level":4,"score":0.998672366142273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9458473920822144},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.7513116598129272},{"id":"https://openalex.org/C2776606491","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid agent","level":4,"score":0.6844663023948669},{"id":"https://openalex.org/C2909564963","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid drugs","level":4,"score":0.6782110333442688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6489239931106567},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.528003454208374},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45316874980926514},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36977723240852356},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20403382182121277}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002231","descriptor_name":"Carbimazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm199601253340403","doi":"https://doi.org/10.1056/nejm199601253340403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm199601253340403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:8531998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8531998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1995925479","https://openalex.org/W2008633542","https://openalex.org/W2032026491","https://openalex.org/W2043410596","https://openalex.org/W2046240238","https://openalex.org/W2049754499","https://openalex.org/W2069033081","https://openalex.org/W2074707507","https://openalex.org/W2076719939","https://openalex.org/W2099851500","https://openalex.org/W2120384440","https://openalex.org/W2245087195","https://openalex.org/W2314427644","https://openalex.org/W2326145828","https://openalex.org/W2335515807","https://openalex.org/W4236249113","https://openalex.org/W4244868009"],"related_works":["https://openalex.org/W2012535752","https://openalex.org/W1994143013","https://openalex.org/W2367057676","https://openalex.org/W2106096662","https://openalex.org/W2144402914","https://openalex.org/W2050086604","https://openalex.org/W2006636103","https://openalex.org/W1963734594","https://openalex.org/W2043763452","https://openalex.org/W3024407832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Antithyroid":[1],"drugs":[2],"are":[3,54],"effective":[4],"in":[5,219,222,235,244,256,269,274],"patients":[6,44,72,80,91,201,221,273,292],"with":[7,29,34,58,73,293],"hyperthyroidism":[8],"due":[9],"to":[10,143,170,178,291],"Graves'":[11,74,88,294],"disease,":[12],"but":[13,161],"the":[14,66,114,133,136,151,154,171,174,192,199,236,245,253,257,261,275,307],"rate":[15,37],"of":[16,68,96,156,164,194,198,208,230,272,283,289,309],"recurrence":[17,36,254,308],"after":[18,140,213,225,300],"treatment":[19,28,67,298],"is":[20],"high.":[21],"In":[22,132,150],"a":[23,35,145,226],"recent":[24],"Japanese":[25],"study,":[26],"adjunctive":[27],"thyroxine":[30],"(T4)":[31],"was":[32,138,158,168,176,215,249],"associated":[33],"20":[38],"times":[39],"lower":[40],"than":[41],"that":[42,263],"among":[43],"who":[45,86],"received":[46,93,105,117],"only":[47],"an":[48,59,180],"antithyroid":[49,60],"drug.":[50],"If":[51],"these":[52],"results":[53],"confirmed,":[55],"combined":[56],"therapy":[57],"drug":[61],"and":[62,83,113,124,173,239,299],"T4":[63,120,125,165,290],"might":[64],"become":[65],"choice":[69],"for":[70,99,108,121,127],"all":[71],"hyperthyroidism.":[75,89,310],"METHODS:":[76],"We":[77],"treated":[78],"111":[79,200],"(89":[81],"women":[82],"22":[84],"men)":[85],"had":[87,202],"All":[90],"initially":[92],"40":[94],"mg":[95],"carbimazole":[97,106,118,134,157,214,237,297],"daily":[98],"one":[100,103,141],"month.":[101],"Then":[102],"group":[104,116,224,238,277],"alone":[107,126],"17":[109,122],"months":[110,123,129,207,234,243],"(52":[111],"patients),":[112],"other":[115],"plus":[119],"18":[128],"(59":[130],"patients).":[131],"group,":[135,153],"dose":[137,155,175],"adjusted":[139,177],"month":[142],"maintain":[144,179],"normal":[146],"serum":[147,182,264],"thyrotropin":[148,183,265],"concentration.":[149],"carbimazole-T4":[152,246,276],"not":[159],"changed,":[160],"100":[162],"micrograms":[163],"per":[166,188],"day":[167],"added":[169],"regimen":[172],"undetectable":[181,268],"concentration":[184],"(<":[185],"0.04":[186],"microU":[187],"milliliter).":[189],"RESULTS:":[190],"At":[191],"time":[193],"our":[195],"analysis,":[196],"53":[197],"completed":[203],"at":[204,279],"least":[205,280],"3":[206],"follow-up":[209],"(median,":[210],"12":[211],"months)":[212],"withdrawn.":[216],"Hyperthyroidism":[217],"recurred":[218],"eight":[220],"each":[223],"mean":[227],"(+/-":[228],"SD)":[229],"6":[231],"+/-":[232,241],"4":[233,242],"7":[240],"group.":[247],"There":[248],"no":[250],"difference":[251],"between":[252],"rates":[255],"two":[258],"groups,":[259],"despite":[260],"fact":[262],"concentrations":[266],"were":[267],"73":[270],"percent":[271,282],"on":[278],"75":[281],"their":[284],"visits.":[285],"CONCLUSIONS:":[286],"The":[287],"administration":[288],"disease":[295],"during":[296],"its":[301],"withdrawal":[302],"neither":[303],"delays":[304],"nor":[305],"prevents":[306]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}