{"id":"https://openalex.org/W2016334212","doi":"https://doi.org/10.1097/00000542-199105000-00018","title":"The Effects of Volatile Anesthetics on L- and T-type Calcium Channel Currents in Canine Cardiac Purkinje Cells","display_name":"The Effects of Volatile Anesthetics on L- and T-type Calcium Channel Currents in Canine Cardiac Purkinje Cells","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2016334212","doi":"https://doi.org/10.1097/00000542-199105000-00018","mag":"2016334212","pmid":"https://pubmed.ncbi.nlm.nih.gov/1850580"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199105000-00018","doi":"https://doi.org/10.1097/00000542-199105000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-199105000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022932860","display_name":"Hanna Eskinder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanna Eskinder","raw_affiliation_strings":["Assistant Professor, Department of Anesthesiology","Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103113524","display_name":"Nancy J. Rusch","orcid":"https://orcid.org/0000-0002-8671-1676","observed_orcids":["https://orcid.org/0000-0002-8671-1676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy\u00a0J. Rusch","raw_affiliation_strings":["Assistant Professor, Department of Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Physiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005069868","display_name":"Franjo D. Supan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franjo\u00a0D. Supan","raw_affiliation_strings":["Research Associate, Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Associate, Department of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407847","display_name":"John P. Kampine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John\u00a0P. Kampine","raw_affiliation_strings":["Professor and Chairman, Department of Anesthesiology; Professor of Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman, Department of Anesthesiology; Professor of Physiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108428644","display_name":"Zeljko J. Bosnjak","orcid":"https://orcid.org/0000-0001-6536-0320","observed_orcids":["https://orcid.org/0000-0001-6536-0320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeljko\u00a0J. Bosnjak","raw_affiliation_strings":["Professor, Departments of Anesthesiology and Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Departments of Anesthesiology and Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.475,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.89060968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"74","issue":"5","first_page":"919","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.8870000243186951},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":1.0},{"id":"https://openalex.org/keywords/enflurane","display_name":"enflurane","score":1.0},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8989999890327454},{"id":"https://openalex.org/keywords/t-type-calcium-channels","display_name":"T-type calcium channels","score":0.9919999837875366},{"id":"https://openalex.org/keywords/current-voltage-characteristics","display_name":"current-voltage characteristics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/canine-heart","display_name":"canine heart","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776932660","wikidata":"https://www.wikidata.org/wiki/Q32921","display_name":"Halothane","level":2,"score":0.7267866730690002},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.7069954872131348},{"id":"https://openalex.org/C2777858289","wikidata":"https://www.wikidata.org/wiki/Q416740","display_name":"Enflurane","level":3,"score":0.6754082441329956},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6640998721122742},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.6166707277297974},{"id":"https://openalex.org/C2777463368","wikidata":"https://www.wikidata.org/wiki/Q2014587","display_name":"Purkinje fibers","level":3,"score":0.5724177360534668},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.5370878577232361},{"id":"https://openalex.org/C2781295685","wikidata":"https://www.wikidata.org/wiki/Q410728","display_name":"Tetraethylammonium","level":3,"score":0.5073136687278748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4887526035308838},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.47725197672843933},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.45184895396232605},{"id":"https://openalex.org/C2780918503","wikidata":"https://www.wikidata.org/wiki/Q7706336","display_name":"Tetraethylammonium chloride","level":3,"score":0.4395258128643036},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4391745924949646},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43464455008506775},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.4117198586463928},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.39456111192703247},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.27488595247268677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25210076570510864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22468581795692444},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.14370104670524597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.056598544120788574},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004737","descriptor_name":"Enflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199105000-00018","doi":"https://doi.org/10.1097/00000542-199105000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-199105000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:1850580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1850580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G533044498","display_name":"CELLULAR EFFECTS OF ANESTHETICS IN THE HEART","funder_award_id":"R01HL039776","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5580171614","display_name":"GENERAL ANESTHESIA AND CARDIOVASCULAR REGULATION","funder_award_id":"K04HL001901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8265485634","display_name":"ANESTHESIOLOGY RESEARCH TRAINING","funder_award_id":"T32GM008377","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029008254","https://openalex.org/W2093867602","https://openalex.org/W2079801558","https://openalex.org/W2076742619","https://openalex.org/W1991919940","https://openalex.org/W2073929634","https://openalex.org/W2012571262","https://openalex.org/W2025998979","https://openalex.org/W2048113245","https://openalex.org/W2416393487"],"abstract_inverted_index":{"The":[0,79],"effects":[1],"of":[2,104,158,180,194,204],"halothane":[3],"(0.45":[4],"and":[5,11,16,22,25,28,34,40,66,76,82,174,188,212,231],"0.9":[6,21,129],"mM,":[7,18,30],"equivalent":[8,19,31],"to":[9,20,32,120,219],"0.7":[10],"1.5%,":[12],"respectively),":[13],"isoflurane":[14],"(0.54":[15],"1.23":[17],"2.0%,":[23],"respectively)":[24,36],"enflurane":[26,189],"(0.65":[27],"1.48":[29],"1.2":[33],"2.5%,":[35],"on":[37],"macroscopic":[38],"L-":[39,211,230],"T-type":[41,147,213,232],"Ca2+":[42,85,148,183,196,205,214],"channel":[43,86,149,184,197,206,215],"currents":[44,87,216],"were":[45,59,88,217],"compared":[46],"in":[47,199],"single":[48],"canine":[49],"cardiac":[50],"Purkinje":[51],"cells":[52],"using":[53],"the":[54,92,178,243],"whole-cell":[55],"voltage-clamp":[56],"technique.":[57],"Cells":[58],"dialyzed":[60],"with":[61,68],"pipette":[62],"solution":[63,71],"containing":[64,72],"CsCl":[65],"superfused":[67],"an":[69,102,156,181],"external":[70],"10":[73],"mM":[74],"BaCl2":[75],"tetraethylammonium":[77],"chloride.":[78],"long-lasting":[80],"(L)":[81],"transient":[83],"(T)-type":[84],"measured":[89],"by":[90,135,141,223],"depolarizing":[91,153],"membrane":[93],"from":[94,101,155],"different":[95],"holding":[96],"potentials":[97],"(HPs).":[98],"Voltage":[99],"steps":[100,154],"HP":[103,157],"either":[105,248],"-80":[106],"or":[107,250],"-70":[108],"mV":[109,160,173],"elicited":[110,161,234],"a":[111,162,191,220],"low":[112],"threshold,":[113],"rapidly":[114],"inactivating":[115],"inward":[116,164],"current":[117,132,165,198,233,252],"at":[118,126,169,235],"-40":[119,159],"-30":[121],"mV,":[122],"which":[123],"maximally":[124,167],"activated":[125,168],"-14":[127],"+/-":[128,171],"mV.":[130],"This":[131],"was":[133,175],"reduced":[134,228],"Ni2+":[136],"(100":[137],"microM)":[138],"but":[139,239],"not":[140,241],"nifedipine":[142],"(1":[143],"microM),":[144],"therefore":[145],"resembling":[146],"current.":[150,185],"In":[151],"contrast,":[152],"sustained":[163],"that":[166,209],"+4.1":[170],"0.8":[172],"nifedipine-sensitive,":[176],"showing":[177],"characteristics":[179],"L-type":[182,251],"Halothane,":[186],"isoflurane,":[187],"produced":[190],"concentration-dependent":[192],"suppression":[193],"total":[195],"every":[200],"cell":[201],"studied.":[202],"Separation":[203],"types":[207],"showed":[208],"both":[210],"depressed":[218],"similar":[221],"extent":[222],"anesthetic":[224],"administration.":[225],"These":[226],"agents":[227],"peak":[229],"each":[236],"pulse":[237],"potential":[238],"did":[240],"shift":[242],"current-voltage":[244],"(I-V)":[245],"relationship":[246],"for":[247],"T-":[249],"activation.(ABSTRACT":[253],"TRUNCATED":[254],"AT":[255],"250":[256],"WORDS)":[257]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}