{"id":"https://openalex.org/W2016331120","doi":"https://doi.org/10.1097/00007890-200407271-00516","title":"SIGNIFICANT REDUCTION OF PROINFLAMMATORY CYTOKINES BY TREATMENT OF THE HUMAN BRAIN DEAD DONOR","display_name":"SIGNIFICANT REDUCTION OF PROINFLAMMATORY CYTOKINES BY TREATMENT OF THE HUMAN BRAIN DEAD DONOR","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2016331120","doi":"https://doi.org/10.1097/00007890-200407271-00516","mag":"2016331120"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200407271-00516","doi":"https://doi.org/10.1097/00007890-200407271-00516","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200407271-00516","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072812848","display_name":"O Kuecuek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O Kuecuek","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052498591","display_name":"L. Mantouvalou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Mantouvalou","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090421032","display_name":"Roman Klemz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Klemz","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077483796","display_name":"Katja Kotsch","orcid":"https://orcid.org/0000-0002-3803-0964","observed_orcids":["https://orcid.org/0000-0002-3803-0964"]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Kotsch","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049060150","display_name":"Hans\u2010Dieter Volk","orcid":"https://orcid.org/0000-0002-7743-6668","observed_orcids":["https://orcid.org/0000-0002-7743-6668"]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H D. Volk","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040837927","display_name":"Sven Jonas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Jonas","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009727699","display_name":"Claus Wesslau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Wesslau","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043440234","display_name":"Stefan G. Tullius","orcid":"https://orcid.org/0000-0003-3058-3166","observed_orcids":["https://orcid.org/0000-0003-3058-3166"]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Tullius","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107841496","display_name":"P. Neuhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Neuhaus","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085883112","display_name":"Johann Pratschke","orcid":"https://orcid.org/0000-0001-9839-1369","observed_orcids":["https://orcid.org/0000-0001-9839-1369"]},"institutions":[{"id":"https://openalex.org/I4210158584","display_name":"German Organ Transplantation Foundation","ror":"https://ror.org/050y6sw38","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210158584"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Pratschke","raw_affiliation_strings":["1Charite, Universit\u00e4tsmedizin Berlin, Germany","2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Charite, Universit\u00e4tsmedizin Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"2Deutsche Stiftung Organtransplantation, DSO Berlin-Brandenburg, Berlin, Germany, 3University Regensburg, Germany","institution_ids":["https://openalex.org/I4210158584","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.16732635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"78","issue":null,"first_page":"197","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-death","display_name":"brain death","score":0.8859999775886536},{"id":"https://openalex.org/keywords/organ-donors","display_name":"organ donors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9810000061988831},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9440000057220459},{"id":"https://openalex.org/keywords/serum-cytokine-levels","display_name":"serum cytokine levels","score":0.7860000133514404},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8550000190734863},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7440000176429749},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.9762449860572815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5155372619628906},{"id":"https://openalex.org/C3019123509","wikidata":"https://www.wikidata.org/wiki/Q223867","display_name":"Brain dead","level":3,"score":0.5061530470848083},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4557501971721649},{"id":"https://openalex.org/C2780778865","wikidata":"https://www.wikidata.org/wiki/Q1130374","display_name":"Laparotomy","level":2,"score":0.41874146461486816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4041610658168793},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3404155969619751},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3257367014884949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3239564895629883},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.17526188492774963},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14562684297561646}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-200407271-00516","doi":"https://doi.org/10.1097/00007890-200407271-00516","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200407271-00516","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069322045","https://openalex.org/W4390782132","https://openalex.org/W190371956","https://openalex.org/W2036091266","https://openalex.org/W2335472743","https://openalex.org/W2558188747","https://openalex.org/W1992128116","https://openalex.org/W2340670136","https://openalex.org/W2772304844","https://openalex.org/W1636458816"],"abstract_inverted_index":{"P20":[0],"Aims:":[1],"Experimentally":[2],"it":[3,44],"was":[4,154],"proven":[5],"that":[6],"the":[7,11,23,31,48,61,68,118,231],"brain":[8,82,144,168,246],"death":[9,145],"of":[10,50,71,117,122,143,151,161,190,203,212,219,241],"donor":[12,57,170,175,243,251],"has":[13],"a":[14,223,238],"significant":[15],"impact":[16],"on":[17],"graft":[18,233],"quality.":[19,234],"No":[20],"data":[21,236],"about":[22],"correlation":[24],"between":[25],"organ":[26,38,62,99,248],"specific":[27],"cytokine":[28],"expression":[29,69,78,189],"and":[30,59,76,146,187,194,225],"corresponding":[32,213],"serum":[33,74,152,188,210],"protein":[34,217],"levels":[35,197,202,211,218],"in":[36,80,167,245],"human":[37,81],"donors":[39,89,93],"are":[40,222],"available":[41],"yet.":[42],"Furthermore":[43],"is":[45,164],"unknown,":[46],"wether":[47],"upregulation":[49],"proinflammatory":[51,191,220],"cytokines":[52,72,124,153,163,192,204,221],"can":[53],"be":[54,255],"reduced":[55],"by":[56,127,156],"treatment":[58,179,244,252],"therefor":[60],"quality":[63],"optimized.":[64],"Methods:":[65],"We":[66],"investigated":[67],"pattern":[70],"comparing":[73],"(n=53)":[75],"tissue":[77,110,123,186],"(n=25)":[79],"dead":[83,169,247],"donors.":[84,200,249],"As":[85],"controls":[86],"served":[87],"living":[88,174,199],"(n=25).":[90],"Additionally":[91],"41":[92],"were":[94,112,125,139],"treated":[95],"with":[96,180,209],"steroids":[97,181],"before":[98,147],"harvesting":[100],"(250":[101],"mg":[102],"initial,":[103],"afterwards":[104],"100":[105],"mg/h":[106],"until":[107],"laparotomy).":[108],"Hepatic":[109],"samples":[111,138],"taken":[113],"immediately":[114],"after":[115,141],"laparotomy":[116],"donor.":[119],"Transcription":[120],"rates":[121],"assessed":[126],"RT-PCR.":[128],"(IL-6,":[129,205],"IL-10,":[130],"CD3,":[131],"TGFb,":[132],"TNFa,":[133],"BAG,":[134],"HO-1,":[135],"Mip1a).":[136],"Serum":[137,216],"gathered":[140],"declaration":[142],"laparotomy.":[148],"The":[149,159],"assessment":[150],"performed":[155],"CBA-kits.":[157],"Results:":[158],"transcription":[160],"pro-inflammatory":[162],"increased":[165],"significantly":[166,184],"livers":[171],"compared":[172],"to":[173,183,198],"grafts":[176],"(p<0.005).":[177],"Donor":[178],"lead":[182],"decreased":[185],"(p<0.01)":[193],"revealed":[195],"comparable":[196],"Tissue":[201],"IL-10)":[206],"correlated":[207],"strongly":[208],"proteines.":[214],"Conclusions:":[215],"valuable":[224],"easy":[226],"accessible":[227],"marker":[228],"for":[229],"defining":[230],"immunological":[232],"Our":[235],"suggest":[237],"beneficial":[239],"effect":[240],"antiinflammatory":[242],"Standardized":[250],"regimens":[253],"should":[254],"established.":[256]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
