{"id":"https://openalex.org/W2016305264","doi":"https://doi.org/10.5530/pj.2012.34.9","title":"Inhibitory effect of Anacyclus pyrethrum extract on acetylcholinesterase enzyme by invitro methods","display_name":"Inhibitory effect of Anacyclus pyrethrum extract on acetylcholinesterase enzyme by invitro methods","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2016305264","doi":"https://doi.org/10.5530/pj.2012.34.9","mag":"2016305264"},"language":"en","primary_location":{"id":"doi:10.5530/pj.2012.34.9","doi":"https://doi.org/10.5530/pj.2012.34.9","is_oa":false,"landing_page_url":"https://doi.org/10.5530/pj.2012.34.9","pdf_url":null,"source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056946386","display_name":"K Sujith","orcid":"https://orcid.org/0009-0003-7337-8282","observed_orcids":["https://orcid.org/0009-0003-7337-8282"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K. Sujith","raw_affiliation_strings":["Department of Pharmacology, K.K College of Pharmacy, Chennai, Tamilnadu-India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, K.K College of Pharmacy, Chennai, Tamilnadu-India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017493531","display_name":"Ronald Darwin C","orcid":"https://orcid.org/0000-0002-2731-8196","observed_orcids":["https://orcid.org/0000-0002-2731-8196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Ronald Darwin","raw_affiliation_strings":["Department of Pharmacology, K.K College of Pharmacy, Chennai, Tamilnadu-India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, K.K College of Pharmacy, Chennai, Tamilnadu-India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084795724","display_name":"V. Suba","orcid":"https://orcid.org/0000-0001-9369-570X","observed_orcids":["https://orcid.org/0000-0001-9369-570X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Suba","raw_affiliation_strings":["Department of pharmacology, National institute of siddha, Chennai, Tamilnadu-India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmacology, National institute of siddha, Chennai, Tamilnadu-India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056946386"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2155,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55799349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"34","first_page":"48","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anacyclus-pyrethrum","display_name":"Anacyclus pyrethrum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticholinesterase-activity","display_name":"anticholinesterase activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7850000262260437},{"id":"https://openalex.org/keywords/n-hexane-extract","display_name":"hexane extract","score":0.621999979019165},{"id":"https://openalex.org/keywords/chloroform-extract","display_name":"chloroform extract","score":0.8700000047683716},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779958359","wikidata":"https://www.wikidata.org/wiki/Q16269373","display_name":"Pyrethrum","level":3,"score":0.8658715486526489},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.7157145738601685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6923093199729919},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6697739362716675},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5134180784225464},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5000948905944824},{"id":"https://openalex.org/C2781144210","wikidata":"https://www.wikidata.org/wiki/Q172275","display_name":"Chloroform","level":2,"score":0.4491262435913086},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36499589681625366},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.359078586101532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.279241144657135},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2782922387123108},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.1990354061126709},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19348198175430298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18723353743553162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05749127268791199},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5530/pj.2012.34.9","doi":"https://doi.org/10.5530/pj.2012.34.9","is_oa":false,"landing_page_url":"https://doi.org/10.5530/pj.2012.34.9","pdf_url":null,"source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1964095432","https://openalex.org/W1971048984","https://openalex.org/W1978530682","https://openalex.org/W1978971424","https://openalex.org/W2007198780","https://openalex.org/W2032652903","https://openalex.org/W2071364419","https://openalex.org/W2093607636","https://openalex.org/W2116488337","https://openalex.org/W2137777161","https://openalex.org/W2912752188","https://openalex.org/W4248995225","https://openalex.org/W4256525953"],"related_works":["https://openalex.org/W7120470599","https://openalex.org/W2385926869","https://openalex.org/W2609816014","https://openalex.org/W2022997414","https://openalex.org/W1979398919","https://openalex.org/W2513513014","https://openalex.org/W2073521714","https://openalex.org/W4224230758","https://openalex.org/W4407232624","https://openalex.org/W1993158727"],"abstract_inverted_index":{"The":[0,14,38,55,125,156,181],"present":[1],"study":[2],"was":[3,59,91,102],"conducted":[4],"to":[5,52,61,93,104,108,178],"evaluate":[6],"acetylcholinesterase":[7],"(AChE)":[8],"inhibitory":[9,29,84,187],"effects":[10],"of":[11,20,44,65,76,88,122,131,153,168,192],"Anacyclus":[12,21,45,66,77,89,132,169,193],"pyrethrum.":[13,194],"hexane,":[15,126],"chloroform":[16,127],"and":[17,33,100,117,128,148],"ethanolic":[18,42,63,129,190],"extract":[19,43,64,75,87,130,167,191],"pyrethrum":[22,46,67,78,90,133,170],"were":[23,134],"tested":[24,135],"for":[25,120,136,151,189],"their":[26,137],"invitro":[27],"anticholinesterase":[28,49,83,138],"effect":[30],"by":[31,34,140],"spectrophotometeric":[32],"TLC":[35,112,141,143,182],"bioassay":[36,113,142,144],"method.":[37],"result":[39],"revealed":[40],"that":[41],"showed":[47,171],"better":[48],"inhibition":[50,139],"compared":[51,177],"other":[53,179],"extracts.":[54,180],"most":[56],"active":[57,157,175],"one":[58,174],"found":[60,92,103],"be":[62,109],"having":[68],"IC50,":[69],"value":[70,96,107],"at":[71,97],"70\u00b11.52":[72],"\u03bcg/ml.":[73,111],"Hexane":[74],"has":[79],"not":[80],"shown":[81],"any":[82],"effect.":[85],"Chloroform":[86],"have":[94,105],"IC50":[95,106],"150\u00b13.68":[98],"\u03bcg/ml":[99],"rivagistmine":[101],"350\u00b15.95":[110],"is":[114,145],"an":[115,146],"easier":[116,147],"rapid":[118,149],"means":[119,150],"detection":[121,152],"enzyme":[123,154],"inhibition.":[124,155],"spots":[158,162,176],"appeared":[159],"as":[160],"white":[161],"on":[163],"yellow":[164],"background.":[165],"Ethanolic":[166],"more":[172],"than":[173],"assay":[183],"also":[184],"demonstrated":[185],"AchE":[186],"activity":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}