{"id":"https://openalex.org/W2016292322","doi":"https://doi.org/10.1155/2012/347141","title":"Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE","display_name":"Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2016292322","doi":"https://doi.org/10.1155/2012/347141","mag":"2016292322","pmid":"https://pubmed.ncbi.nlm.nih.gov/22500087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3303597"},"language":"en","primary_location":{"id":"doi:10.1155/2012/347141","doi":"https://doi.org/10.1155/2012/347141","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/347141","pdf_url":"https://downloads.hindawi.com/journals/bmri/2012/347141.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2012/347141.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089681452","display_name":"Dinglei Su","orcid":"https://orcid.org/0000-0002-8573-3275","observed_orcids":["https://orcid.org/0000-0002-8573-3275"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ding-Lei Su","raw_affiliation_strings":["Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China","Department of Rheumatology and Immunology, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006 Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Department of Rheumatology and Immunology, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006 Nanjing, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072621782","display_name":"Zhimin Lu","orcid":"https://orcid.org/0000-0002-7971-5003","observed_orcids":["https://orcid.org/0000-0002-7971-5003"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Min Lu","raw_affiliation_strings":["Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019198749","display_name":"Minning Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277390","display_name":"Nanjing First Hospital","ror":"https://ror.org/02hw73q19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277390"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min-Ning Shen","raw_affiliation_strings":["Department of Rheumatology and Immunology, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006 Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006 Nanjing, China","institution_ids":["https://openalex.org/I4405277390","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445572","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-3572-2252","observed_orcids":["https://orcid.org/0000-0002-3572-2252"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100629346","display_name":"Lingyun Sun","orcid":"https://orcid.org/0000-0002-8563-2036","observed_orcids":["https://orcid.org/0000-0002-8563-2036"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling-Yun Sun","raw_affiliation_strings":["Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 210008 Nanjing, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100629346"],"corresponding_institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":2.1108,"has_fulltext":true,"cited_by_count":204,"citation_normalized_percentile":{"value":0.90733198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9509999752044678},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8989999890327454},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/baff","display_name":"BAFF","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8050000071525574},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":1.0},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/autoimmune-disease-pathogenesis","display_name":"autoimmune disease pathogenesis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6795841455459595},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6322830319404602},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5792081952095032},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5745682120323181},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5515024662017822},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.51996910572052},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5010979175567627},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.44756805896759033},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4222470819950104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3316740393638611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3248690962791443},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1988353729248047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2012/347141","doi":"https://doi.org/10.1155/2012/347141","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/347141","pdf_url":"https://downloads.hindawi.com/journals/bmri/2012/347141.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2330909","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3303597","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22500087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22500087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedicine & biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3303597","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3303597/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Biotechnol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.6508","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.6508","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/42/3d/J_Biomed_Biotechnol_2012_Feb_15_2012_347141.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1155/2012/347141","doi":"https://doi.org/10.1155/2012/347141","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/347141","pdf_url":"https://downloads.hindawi.com/journals/bmri/2012/347141.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedicine and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016292322.pdf","grobid_xml":"https://content.openalex.org/works/W2016292322.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W299753989","https://openalex.org/W1505026047","https://openalex.org/W1509863491","https://openalex.org/W1514511317","https://openalex.org/W1517658874","https://openalex.org/W1536123386","https://openalex.org/W1537631996","https://openalex.org/W1572310151","https://openalex.org/W1602485016","https://openalex.org/W1773520471","https://openalex.org/W1790240239","https://openalex.org/W1793205621","https://openalex.org/W1834055687","https://openalex.org/W1840567140","https://openalex.org/W1846501109","https://openalex.org/W1867937417","https://openalex.org/W1886435492","https://openalex.org/W1896407552","https://openalex.org/W1902639440","https://openalex.org/W1936648860","https://openalex.org/W1937760409","https://openalex.org/W1943043586","https://openalex.org/W1965873680","https://openalex.org/W1966223430","https://openalex.org/W1966613111","https://openalex.org/W1968476672","https://openalex.org/W1969740417","https://openalex.org/W1971530944","https://openalex.org/W1972536594","https://openalex.org/W1974453246","https://openalex.org/W1975085076","https://openalex.org/W1975249184","https://openalex.org/W1976678451","https://openalex.org/W1978302597","https://openalex.org/W1983045668","https://openalex.org/W1983515757","https://openalex.org/W1983899969","https://openalex.org/W1984035854","https://openalex.org/W1984613853","https://openalex.org/W1985157285","https://openalex.org/W1986803467","https://openalex.org/W1988227555","https://openalex.org/W1991141143","https://openalex.org/W1995465129","https://openalex.org/W1996008717","https://openalex.org/W1996164589","https://openalex.org/W1998091116","https://openalex.org/W1999833479","https://openalex.org/W2004488054","https://openalex.org/W2006140590","https://openalex.org/W2006249161","https://openalex.org/W2008411071","https://openalex.org/W2009309711","https://openalex.org/W2010854505","https://openalex.org/W2012680181","https://openalex.org/W2016899230","https://openalex.org/W2017091950","https://openalex.org/W2019348446","https://openalex.org/W2019497869","https://openalex.org/W2021525259","https://openalex.org/W2022291166","https://openalex.org/W2022901323","https://openalex.org/W2023139698","https://openalex.org/W2024490058","https://openalex.org/W2024742513","https://openalex.org/W2028666164","https://openalex.org/W2030175762","https://openalex.org/W2030194724","https://openalex.org/W2032474941","https://openalex.org/W2035094814","https://openalex.org/W2036989655","https://openalex.org/W2039315278","https://openalex.org/W2039378822","https://openalex.org/W2039992202","https://openalex.org/W2042387310","https://openalex.org/W2043298079","https://openalex.org/W2045625161","https://openalex.org/W2049278423","https://openalex.org/W2049526770","https://openalex.org/W2049858255","https://openalex.org/W2054249476","https://openalex.org/W2055816409","https://openalex.org/W2058081546","https://openalex.org/W2060019843","https://openalex.org/W2061210405","https://openalex.org/W2063870250","https://openalex.org/W2065907531","https://openalex.org/W2066704395","https://openalex.org/W2066728093","https://openalex.org/W2067146456","https://openalex.org/W2069968649","https://openalex.org/W2070391335","https://openalex.org/W2071061915","https://openalex.org/W2071978180","https://openalex.org/W2075450457","https://openalex.org/W2075768884","https://openalex.org/W2076032448","https://openalex.org/W2076224496","https://openalex.org/W2077358378","https://openalex.org/W2077492907","https://openalex.org/W2078198072","https://openalex.org/W2078800870","https://openalex.org/W2079494090","https://openalex.org/W2081521873","https://openalex.org/W2082377790","https://openalex.org/W2083859186","https://openalex.org/W2085237060","https://openalex.org/W2085894509","https://openalex.org/W2086387065","https://openalex.org/W2087983368","https://openalex.org/W2088737310","https://openalex.org/W2090851364","https://openalex.org/W2092567494","https://openalex.org/W2092975931","https://openalex.org/W2094619835","https://openalex.org/W2095537212","https://openalex.org/W2096286605","https://openalex.org/W2097556922","https://openalex.org/W2097885269","https://openalex.org/W2099456939","https://openalex.org/W2099932920","https://openalex.org/W2101507698","https://openalex.org/W2103093622","https://openalex.org/W2103690233","https://openalex.org/W2108644937","https://openalex.org/W2111034338","https://openalex.org/W2113313714","https://openalex.org/W2114649991","https://openalex.org/W2120010406","https://openalex.org/W2121019096","https://openalex.org/W2121592594","https://openalex.org/W2121646580","https://openalex.org/W2122331051","https://openalex.org/W2122995291","https://openalex.org/W2127354755","https://openalex.org/W2128728003","https://openalex.org/W2131659920","https://openalex.org/W2133779525","https://openalex.org/W2136394997","https://openalex.org/W2137266938","https://openalex.org/W2139034967","https://openalex.org/W2139476329","https://openalex.org/W2140296331","https://openalex.org/W2141028706","https://openalex.org/W2145272984","https://openalex.org/W2145345130","https://openalex.org/W2146948404","https://openalex.org/W2149295409","https://openalex.org/W2149353058","https://openalex.org/W2149480249","https://openalex.org/W2149654975","https://openalex.org/W2151372649","https://openalex.org/W2151675691","https://openalex.org/W2152507275","https://openalex.org/W2153887194","https://openalex.org/W2154887345","https://openalex.org/W2156451662","https://openalex.org/W2156451877","https://openalex.org/W2161074777","https://openalex.org/W2161112755","https://openalex.org/W2162450874","https://openalex.org/W2164979183","https://openalex.org/W2166022914","https://openalex.org/W2168888135","https://openalex.org/W2300885738","https://openalex.org/W2317430088","https://openalex.org/W2334971712","https://openalex.org/W2412862011","https://openalex.org/W2413143616","https://openalex.org/W4285719527","https://openalex.org/W4313331748"],"related_works":["https://openalex.org/W7098987886","https://openalex.org/W2111270619","https://openalex.org/W3212225433","https://openalex.org/W7096148264","https://openalex.org/W2103540095","https://openalex.org/W2021677937","https://openalex.org/W1958202382","https://openalex.org/W2508852714","https://openalex.org/W4415983618","https://openalex.org/W7095281937"],"abstract_inverted_index":{"SLE":[0],"is":[1],"an":[2],"autoimmune":[3],"inflammatory":[4],"disease":[5],"in":[6,80],"which":[7],"various":[8],"pro-":[9],"and":[10,21,37,41,75,87],"anti-inflammatory":[11],"cytokines,":[12],"including":[13],"TGF-\u03b2,":[14],"IL-10,":[15],"BAFF,":[16],"IL-6,":[17],"IFN-\u03b1,":[18],"IFN-\u03b3,":[19],"IL-17,":[20],"IL-23,":[22],"play":[23],"crucial":[24],"pathogenic":[25,85],"roles.":[26],"Virtually,":[27],"all":[28],"these":[29,78],"cytokines":[30,79],"can":[31,51],"be":[32],"generated":[33],"by":[34],"both":[35],"innate":[36],"adaptive":[38],"immune":[39,64],"cells":[40],"exert":[42],"different":[43],"effects":[44],"depending":[45],"on":[46,71],"specific":[47],"local":[48],"microenvironment.":[49],"They":[50],"also":[52],"interact":[53],"with":[54],"each":[55],"other,":[56],"forming":[57],"a":[58],"complex":[59],"network":[60],"to":[61],"maintain":[62],"delicate":[63],"homeostasis.":[65],"In":[66],"this":[67],"paper,":[68],"we":[69],"elaborate":[70],"the":[72,90],"abnormal":[73],"secretion":[74],"functions":[76],"of":[77,92],"SLE,":[81],"analyze":[82],"their":[83],"potential":[84],"roles,":[86],"probe":[88],"into":[89],"possibility":[91],"them":[93],"being":[94],"utilized":[95],"as":[96],"targets":[97],"for":[98],"therapy.":[99]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}