{"id":"https://openalex.org/W2016291989","doi":"https://doi.org/10.1096/fj.03-0782fje","title":"Lipids partition caveolin\u20101 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesis","display_name":"Lipids partition caveolin\u20101 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesis","publication_year":2004,"publication_date":"2004-03-04","ids":{"openalex":"https://openalex.org/W2016291989","doi":"https://doi.org/10.1096/fj.03-0782fje","mag":"2016291989","pmid":"https://pubmed.ncbi.nlm.nih.gov/15001554"},"language":"en","primary_location":{"id":"doi:10.1096/fj.03-0782fje","doi":"https://doi.org/10.1096/fj.03-0782fje","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.03-0782fje","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080587189","display_name":"Mirko J. Robenek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko J. Robenek","raw_affiliation_strings":["University Children's Hospital University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109908295","display_name":"Nicholas J. Severs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas J. Severs","raw_affiliation_strings":["Imperial College London National Heart and Lung Institute London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London National Heart and Lung Institute London UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064058853","display_name":"Karin Schlattmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Schlattmann","raw_affiliation_strings":["Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948312","display_name":"Gabriele A.M. Plenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriele Plenz","raw_affiliation_strings":["Department of Cardiology and Angiology, and Department of Thoracic and Cardiovascular Surgery University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, and Department of Thoracic and Cardiovascular Surgery University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110428741","display_name":"Klaus\u2010Peter Zimmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus-Peter Zimmer","raw_affiliation_strings":["University Children's Hospital University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111778864","display_name":"David Troyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Troyer","raw_affiliation_strings":["Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006492057","display_name":"Horst Robenek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Horst Robenek","raw_affiliation_strings":["Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Ultrastructure Research, Institute for Arteriosclerosis Research University of M\u00fcnster M\u00fcnster Germany","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":3.8125,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.93099975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"7","first_page":"866","last_page":"868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.10189999639987946,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":1.0},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lipid-droplet-formation","display_name":"lipid droplet formation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-membrane","display_name":"endoplasmic reticulum membrane","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cholesterol-transport","display_name":"cholesterol transport","score":0.6970000267028809},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/membrane-leaflets","display_name":"membrane leaflets","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8677977323532104},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.7510806918144226},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7000279426574707},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6282072067260742},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6018099784851074},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.6016091108322144},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.5891606211662292},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.5185595154762268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5124741196632385},{"id":"https://openalex.org/C134088382","wikidata":"https://www.wikidata.org/wiki/Q6556364","display_name":"Lipid microdomain","level":3,"score":0.46432796120643616},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4444851875305176},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4303074777126312},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37281981110572815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30887120962142944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29906702041625977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005614","descriptor_name":"Freeze Fracturing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016628","descriptor_name":"Replica Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022461","descriptor_name":"Caveolins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.03-0782fje","doi":"https://doi.org/10.1096/fj.03-0782fje","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.03-0782fje","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:15001554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15001554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W139394080","https://openalex.org/W645995690","https://openalex.org/W1913982549","https://openalex.org/W1966673014","https://openalex.org/W1994580268","https://openalex.org/W2012357528","https://openalex.org/W2015661133","https://openalex.org/W2039330806","https://openalex.org/W2041298355","https://openalex.org/W2043237666","https://openalex.org/W2053948748","https://openalex.org/W2068800887","https://openalex.org/W2069444054","https://openalex.org/W2069599425","https://openalex.org/W2072291193","https://openalex.org/W2074406830","https://openalex.org/W2077628510","https://openalex.org/W2082075636","https://openalex.org/W2083163414","https://openalex.org/W2087222747","https://openalex.org/W2088432812","https://openalex.org/W2115320622","https://openalex.org/W2116803744","https://openalex.org/W2147963733","https://openalex.org/W2154346498","https://openalex.org/W2184462655"],"related_works":["https://openalex.org/W2770173756","https://openalex.org/W2116803744","https://openalex.org/W2272253481","https://openalex.org/W2052016645","https://openalex.org/W7114778892","https://openalex.org/W2115320622","https://openalex.org/W781527989","https://openalex.org/W2507774978","https://openalex.org/W7154162276","https://openalex.org/W3039835639"],"abstract_inverted_index":{"Caveolin-1,":[0],"a":[1],"putative":[2],"mediator":[3],"of":[4,18,48,92,116,127,142],"intracellular":[5],"cholesterol":[6],"transport,":[7],"is":[8,34],"generally":[9],"assumed":[10],"to":[11,36,39,53,135,146],"be":[12,37,136,147],"integrated":[13],"into":[14,149],"the":[15,28,40,45,55,66,113,123,139,150],"cytoplasmic":[16,46,98],"leaflets":[17,91,141],"all":[19],"cellular":[20],"membranes.":[21],"Lipid":[22],"droplets":[23,64,77],"form":[24],"by":[25,68,153],"budding":[26],"at":[27],"endoplasmic":[29,90,140],"reticulum":[30],"(ER),":[31],"and":[32,51,74,145],"caveolin-1":[33,61,70,88,128,133],"thought":[35],"transferred":[38,148],"droplet":[41,56,106,118,151,157],"surface":[42],"along":[43],"with":[44,112],"leaflet":[47],"ER":[49,67,72,93,143],"membranes":[50,73,94,144],"not":[52],"enter":[54],"core.":[57],"We":[58,86,120],"explored":[59],"how":[60],"accesses":[62],"lipid":[63,76,105,117],"from":[65,138],"localizing":[69],"in":[71,75,78,89,97,104],"cultured":[79],"smooth":[80],"muscle":[81],"cells":[82],"using":[83],"freeze-fracture":[84],"immunocytochemistry.":[85],"detected":[87],"but":[95],"never":[96],"leaflets.":[99],"Caveolin-1":[100],"was":[101],"also":[102],"present":[103],"cores.":[107],"These":[108],"findings":[109],"are":[110],"incompatible":[111],"current":[114],"hypothesis":[115],"biogenesis.":[119],"suggest":[121],"that":[122],"inherent":[124],"high":[125],"affinity":[126],"for":[129],"neutral":[130],"lipids":[131,155],"causes":[132],"molecules":[134],"extracted":[137],"core":[152],"inundating":[154],"during":[156],"formation.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}