{"id":"https://openalex.org/W2016288025","doi":"https://doi.org/10.1016/0167-4838(94)00170-l","title":"Hemorrhagic principles in the venom of Bitis arietans, a viperous snake. I. Purification and characterization","display_name":"Hemorrhagic principles in the venom of Bitis arietans, a viperous snake. I. Purification and characterization","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2016288025","doi":"https://doi.org/10.1016/0167-4838(94)00170-l","mag":"2016288025","pmid":"https://pubmed.ncbi.nlm.nih.gov/7811732"},"language":"en","primary_location":{"id":"doi:10.1016/0167-4838(94)00170-l","doi":"https://doi.org/10.1016/0167-4838(94)00170-l","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(94)00170-l","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110101667","display_name":"Tamotsu Omori\u2010Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamotsu Omori-Satoh","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, National Institute of Health, Tokyo, Japan","Department of Biochemistry and Cell Biology, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, National Institute of Health, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]},{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067577327","display_name":"Yoshio Yamakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Yamakawa","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108803891","display_name":"Yoshiaki Nagaoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiaki Nagaoka","raw_affiliation_strings":["Bacterial and Blood Products, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacterial and Blood Products, National Institute of Health, Toyama 1-23-1, Shinjuku, Tokyo 162, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017719358","display_name":"Dietrich Mebs","orcid":"https://orcid.org/0000-0002-6300-7475","observed_orcids":["https://orcid.org/0000-0002-6300-7475"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietrich Mebs","raw_affiliation_strings":["Zentrum der Rechtsmedizin, Frankfurt University, Frankfurt, D-6000, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Rechtsmedizin, Frankfurt University, Frankfurt, D-6000, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0649,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83136364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1246","issue":"1","first_page":"61","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10332","display_name":"Amphibian and Reptile Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitis-arietans","display_name":"Bitis arietans","score":0.984000027179718},{"id":"https://openalex.org/keywords/hemorrhagic-activity","display_name":"hemorrhagic activity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/venom-purification","display_name":"venom purification","score":0.6269999742507935},{"id":"https://openalex.org/keywords/protein-characterization","display_name":"protein characterization","score":0.5170000195503235},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.7749999761581421},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/snake-venom-toxins","display_name":"snake venom toxins","score":0.47699999809265137},{"id":"https://openalex.org/keywords/edta-inhibition","display_name":"EDTA inhibition","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cysteine-inhibition","display_name":"cysteine inhibition","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.8209095597267151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6420354247093201},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.6301500797271729},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5254570245742798},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5064569711685181},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.4835197925567627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4766688644886017},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.4133240580558777},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.4106748104095459},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20344746112823486}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002863","descriptor_name":"Chromogenic Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0167-4838(94)00170-l","doi":"https://doi.org/10.1016/0167-4838(94)00170-l","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(94)00170-l","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},{"id":"pmid:7811732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7811732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W234460068","https://openalex.org/W327926060","https://openalex.org/W590658562","https://openalex.org/W607880764","https://openalex.org/W1482593346","https://openalex.org/W1500684594","https://openalex.org/W1538333669","https://openalex.org/W1546663611","https://openalex.org/W1968826399","https://openalex.org/W1985981054","https://openalex.org/W1988424611","https://openalex.org/W2003369515","https://openalex.org/W2007603894","https://openalex.org/W2024187260","https://openalex.org/W2027754536","https://openalex.org/W2031855181","https://openalex.org/W2034699968","https://openalex.org/W2036192239","https://openalex.org/W2036486640","https://openalex.org/W2041496453","https://openalex.org/W2044607111","https://openalex.org/W2045673607","https://openalex.org/W2048023253","https://openalex.org/W2049856155","https://openalex.org/W2050927493","https://openalex.org/W2051039569","https://openalex.org/W2051859282","https://openalex.org/W2065016721","https://openalex.org/W2068329737","https://openalex.org/W2078128292","https://openalex.org/W2082228931","https://openalex.org/W2085173549","https://openalex.org/W2100837269","https://openalex.org/W2119586900","https://openalex.org/W2172575392","https://openalex.org/W2176433489","https://openalex.org/W2282054059","https://openalex.org/W6617560440"],"related_works":["https://openalex.org/W2085173549","https://openalex.org/W2059876929","https://openalex.org/W2073141167","https://openalex.org/W2039100033","https://openalex.org/W2331366883","https://openalex.org/W2048663562","https://openalex.org/W2052408882","https://openalex.org/W2052119671","https://openalex.org/W2079927443","https://openalex.org/W2010676381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
