{"id":"https://openalex.org/W2016286526","doi":"https://doi.org/10.1002/jbm.a.30618","title":"Effects of the length of crosslink chain on poly(2\u2010hydroxyethyl methacrylate) (pHEMA) swelling and biomechanical properties","display_name":"Effects of the length of crosslink chain on poly(2\u2010hydroxyethyl methacrylate) (pHEMA) swelling and biomechanical properties","publication_year":2005,"publication_date":"2005-12-12","ids":{"openalex":"https://openalex.org/W2016286526","doi":"https://doi.org/10.1002/jbm.a.30618","mag":"2016286526","pmid":"https://pubmed.ncbi.nlm.nih.gov/16345096"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.30618","doi":"https://doi.org/10.1002/jbm.a.30618","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30618","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049469702","display_name":"Guillaume Mabilleau","orcid":"https://orcid.org/0000-0003-1445-329X","observed_orcids":["https://orcid.org/0000-0003-1445-329X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Mabilleau","raw_affiliation_strings":["INSERM, EMI 0335-LHEA, ANGERS, F-49045 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, EMI 0335-LHEA, ANGERS, F-49045 France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086104289","display_name":"Izabela\u2010Cristina Stancu","orcid":"https://orcid.org/0000-0003-0685-3947","observed_orcids":["https://orcid.org/0000-0003-0685-3947"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I61641377","display_name":"Universitatea Na\u021bional\u0103 de \u0218tiin\u021b\u0103 \u0219i Tehnologie Politehnica Bucure\u0219ti","ror":"https://ror.org/0558j5q12","country_code":"RO","type":"education","lineage":["https://openalex.org/I61641377"]}],"countries":["FR","RO"],"is_corresponding":false,"raw_author_name":"I. C. Stancu","raw_affiliation_strings":["Department of Macromolecular Chemistry, Industrial Chemistry Faculty, University Politehnica, Bucharest, RO-71101 Romania","INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Macromolecular Chemistry, Industrial Chemistry Faculty, University Politehnica, Bucharest, RO-71101 Romania","institution_ids":["https://openalex.org/I61641377"]},{"raw_affiliation_string":"INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062610437","display_name":"T. Honor\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167108","display_name":"Centre de Transfert de Technologie du Mans","ror":"https://ror.org/05n3hnq20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167108"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Honor\u00e9","raw_affiliation_strings":["CTTM, Le Mans, F-72000 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CTTM, Le Mans, F-72000 France","institution_ids":["https://openalex.org/I4210167108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026181500","display_name":"Gilbert Legeay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167108","display_name":"Centre de Transfert de Technologie du Mans","ror":"https://ror.org/05n3hnq20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167108"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Legeay","raw_affiliation_strings":["CTTM, Le Mans, F-72000 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CTTM, Le Mans, F-72000 France","institution_ids":["https://openalex.org/I4210167108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109929885","display_name":"Corneliu Cincu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I61641377","display_name":"Universitatea Na\u021bional\u0103 de \u0218tiin\u021b\u0103 \u0219i Tehnologie Politehnica Bucure\u0219ti","ror":"https://ror.org/0558j5q12","country_code":"RO","type":"education","lineage":["https://openalex.org/I61641377"]}],"countries":["FR","RO"],"is_corresponding":false,"raw_author_name":"C. Cincu","raw_affiliation_strings":["Department of Macromolecular Chemistry, Industrial Chemistry Faculty, University Politehnica, Bucharest, RO-71101 Romania","INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Macromolecular Chemistry, Industrial Chemistry Faculty, University Politehnica, Bucharest, RO-71101 Romania","institution_ids":["https://openalex.org/I61641377"]},{"raw_affiliation_string":"INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109801217","display_name":"Michel F\u00e9lix Basl\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. F. Basl\u00e9","raw_affiliation_strings":["INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015664452","display_name":"Daniel Chappard","orcid":"https://orcid.org/0000-0002-5886-9513","observed_orcids":["https://orcid.org/0000-0002-5886-9513"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"D. Chappard","raw_affiliation_strings":["INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, EMI 0335\u2013LHEA, ANGERS, F-49045 France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015664452"],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":1.0739,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.72424558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77A","issue":"1","first_page":"35","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-2-hydroxyethyl-methacrylate","display_name":"poly(2-hydroxyethyl methacrylate)","score":0.9990000128746033},{"id":"https://openalex.org/keywords/crosslinking-agents","display_name":"crosslinking agents","score":0.9129999876022339},{"id":"https://openalex.org/keywords/swelling","display_name":"swelling","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tissue-mechanics","display_name":"tissue mechanics","score":0.9139999747276306},{"id":"https://openalex.org/keywords/surface-roughness","display_name":"surface roughness","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hardness","display_name":"hardness","score":0.9240000247955322},{"id":"https://openalex.org/keywords/stiffness","display_name":"stiffness","score":0.972000002861023},{"id":"https://openalex.org/keywords/fractal-analysis","display_name":"fractal analysis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/divinylbenzene","display_name":"divinylbenzene","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ethylene-glycol-dimethacrylate","display_name":"ethylene glycol dimethacrylate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/poly-ethylene-glycol-diacrylate","display_name":"poly(ethylene glycol) diacrylate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hydrated-polymers","display_name":"hydrated polymers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bone-substitutes","display_name":"bone substitutes","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.8711591958999634},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.6666675806045532},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6612498760223389},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5364789366722107},{"id":"https://openalex.org/C2910255311","wikidata":"https://www.wikidata.org/wiki/Q424799","display_name":"2-Hydroxyethyl Methacrylate","level":5,"score":0.5300920605659485},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.5290316939353943},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.5218740701675415},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.49113819003105164},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.4601612091064453},{"id":"https://openalex.org/C2778140322","wikidata":"https://www.wikidata.org/wiki/Q424799","display_name":"(Hydroxyethyl)methacrylate","level":5,"score":0.45695000886917114},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.41109102964401245},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3846890926361084},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.37019938230514526},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003188","descriptor_name":"Composite Resins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006244","descriptor_name":"Hardness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011102","descriptor_name":"Polyhydroxyethyl Methacrylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.30618","doi":"https://doi.org/10.1002/jbm.a.30618","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30618","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:16345096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16345096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W162937009","https://openalex.org/W169161945","https://openalex.org/W582150317","https://openalex.org/W1505352099","https://openalex.org/W1524961740","https://openalex.org/W1650566497","https://openalex.org/W1966714061","https://openalex.org/W1967426304","https://openalex.org/W1967523171","https://openalex.org/W1969508913","https://openalex.org/W1971605721","https://openalex.org/W1981215463","https://openalex.org/W1994439637","https://openalex.org/W1997978522","https://openalex.org/W1998477845","https://openalex.org/W2013077229","https://openalex.org/W2019080776","https://openalex.org/W2032309579","https://openalex.org/W2034024883","https://openalex.org/W2041322047","https://openalex.org/W2042716171","https://openalex.org/W2046425506","https://openalex.org/W2057428406","https://openalex.org/W2060063435","https://openalex.org/W2062572003","https://openalex.org/W2063675075","https://openalex.org/W2071154318","https://openalex.org/W2071522072","https://openalex.org/W2078615529","https://openalex.org/W2082570716","https://openalex.org/W2084543305","https://openalex.org/W2085657483","https://openalex.org/W2087747129","https://openalex.org/W2089210988","https://openalex.org/W2105604163","https://openalex.org/W2117435043","https://openalex.org/W2314659927","https://openalex.org/W3100791499","https://openalex.org/W4285719527","https://openalex.org/W4322484201"],"related_works":["https://openalex.org/W2105604163","https://openalex.org/W2475143482","https://openalex.org/W2139749717","https://openalex.org/W2363184230","https://openalex.org/W1998037888","https://openalex.org/W2040753682","https://openalex.org/W4411902544","https://openalex.org/W2967620985","https://openalex.org/W2057237349","https://openalex.org/W2504795435"],"abstract_inverted_index":{"Polymers":[0],"are":[1],"widely":[2],"used":[3],"in":[4,38,108,116,171],"medicine":[5],"for":[6,13,132,165],"vascular":[7],"prostheses,":[8],"bone":[9],"substitutes,":[10],"and":[11,59,72,88,102,118,143,154],"devices":[12],"controlled":[14,166],"release.":[15],"Among":[16],"these":[17],"polymers,":[18],"poly(2-hydroxyethyl":[19],"methacrylate)":[20],"(pHEMA)":[21],"is":[22],"the":[23,39,49,96,127,137,140,159],"most":[24,161],"employed.":[25],"To":[26],"confer":[27],"particular":[28],"properties,":[29],"pHEMA":[30,63,150],"can":[31],"be":[32,158],"copolymerized":[33],"with":[34],"other":[35],"monomers":[36],"or":[37,43,145],"presence":[40],"of":[41,48,51,61,139,147,168],"plasticizers":[42],"crosslinking":[44,75,163],"agents.":[45],"The":[46],"influence":[47],"length":[50,138],"crosslink":[52,141],"chains":[53],"on":[54,123],"swelling,":[55],"surface":[56,109],"rugosity,":[57],"hardness,":[58],"stiffness":[60,146],"crosslinked":[62,149],"were":[64,93,121,130,151],"studied":[65],"by":[66,112],"several":[67],"techniques,":[68],"including":[69],"fractal":[70,113],"analysis":[71],"AFM.":[73],"Four":[74],"agents":[76,164],"(divinyl":[77],"benzene,":[78],"DVB;":[79],"ethylene":[80],"glycol":[81,85,90],"dimethacrylate,":[82],"EGDMA;":[83],"tetraethylene":[84],"diacrylate,":[86,91],"TEGDA;":[87],"polyethylene":[89],"PEGDA)":[92],"added":[94],"to":[95,157],"bulk":[97],"polymerization":[98],"mixture.":[99],"Only":[100],"linear":[101],"PEGDA-pHEMA":[103],"presented":[104],"a":[105],"significant":[106],"decrease":[107],"roughness":[110],"confirmed":[111],"analysis.":[114],"Differences":[115],"hardness":[117,144],"biomechanical":[119],"properties":[120],"evidenced":[122],"dried":[124],"polymers":[125],"but":[126],"highest":[128],"differences":[129],"exhibited":[131],"hydrated":[133,148],"pHEMA.":[134],"Correlations":[135],"between":[136],"chain":[142],"evidenced.":[152],"TEGDA":[153],"PEGDA":[155],"appeared":[156],"two":[160],"suitable":[162],"release":[167],"bioactive":[169],"molecules":[170],"bone.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}