{"id":"https://openalex.org/W2016283072","doi":"https://doi.org/10.3390/ijms151222331","title":"Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis","display_name":"Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis","publication_year":2014,"publication_date":"2014-12-03","ids":{"openalex":"https://openalex.org/W2016283072","doi":"https://doi.org/10.3390/ijms151222331","mag":"2016283072","pmid":"https://pubmed.ncbi.nlm.nih.gov/25479078","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4284711"},"language":"en","primary_location":{"id":"doi:10.3390/ijms151222331","doi":"https://doi.org/10.3390/ijms151222331","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151222331","pdf_url":"https://www.mdpi.com/1422-0067/15/12/22331/pdf?version=1417600071","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/15/12/22331/pdf?version=1417600071","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046990277","display_name":"Antonio Ieni","orcid":"https://orcid.org/0000-0003-2878-3572","observed_orcids":["https://orcid.org/0000-0003-2878-3572","https://orcid.org/0000-0002-0493-7621"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Ieni","raw_affiliation_strings":["Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. calaienco@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. calaienco@hotmail.com","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057940142","display_name":"Valeria Barresi","orcid":"https://orcid.org/0000-0001-7086-1920","observed_orcids":["https://orcid.org/0000-0001-7086-1920"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Barresi","raw_affiliation_strings":["Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. vbarresi@unime.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. vbarresi@unime.it","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061835885","display_name":"Rosario Caltabiano","orcid":"https://orcid.org/0000-0001-8591-8010","observed_orcids":["https://orcid.org/0000-0001-8591-8010"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosario Caltabiano","raw_affiliation_strings":["Department \"G.F. Ingrassia\", Section of Anatomic Pathology, University of Catania,  Catania 95123, Italy","Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania 95123, Italy. rosario.caltabiano@unict.it"],"raw_orcid":"https://orcid.org/0000-0001-8591-8010","affiliations":[{"raw_affiliation_string":"Department \"G.F. Ingrassia\", Section of Anatomic Pathology, University of Catania,  Catania 95123, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania 95123, Italy. rosario.caltabiano@unict.it","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077263297","display_name":"Alessia Caleo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Caleo","raw_affiliation_strings":["Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy","Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy. alessia.caleo@unisa.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy. alessia.caleo@unisa.it","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081648394","display_name":"Luca Reggiani Bonetti","orcid":"https://orcid.org/0000-0002-9917-4080","observed_orcids":["https://orcid.org/0000-0002-9917-4080"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Bonetti","raw_affiliation_strings":["Department of Diagnostic Medicine, Clinics and Public Health, Section of Pathologic Anatomy, University of Modena, Modena 41121, Italy","Department of Diagnostic Medicine, Clinics and Public Health, Section of Pathologic Anatomy, University of Modena, Modena 41121, Italy. reggiani.luca@policlinico.mo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Medicine, Clinics and Public Health, Section of Pathologic Anatomy, University of Modena, Modena 41121, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Diagnostic Medicine, Clinics and Public Health, Section of Pathologic Anatomy, University of Modena, Modena 41121, Italy. reggiani.luca@policlinico.mo.it","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111577916","display_name":"Salvatore Lanzafame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Lanzafame","raw_affiliation_strings":["Department \"G.F. Ingrassia\", Section of Anatomic Pathology, University of Catania,  Catania 95123, Italy","Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania 95123, Italy. lanzafas@unict.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department \"G.F. Ingrassia\", Section of Anatomic Pathology, University of Catania,  Catania 95123, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania 95123, Italy. lanzafas@unict.it","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087427494","display_name":"Pio Zeppa","orcid":"https://orcid.org/0000-0001-7358-5925","observed_orcids":["https://orcid.org/0000-0001-7358-5925"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pio Zeppa","raw_affiliation_strings":["Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy","Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy. pzeppa@unisa.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy. pzeppa@unisa.it","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058700206","display_name":"Rosario Alberto Caruso","orcid":"https://orcid.org/0000-0001-8723-7833","observed_orcids":["https://orcid.org/0000-0001-8723-7833"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosario Caruso","raw_affiliation_strings":["Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. rosariocaruso@tin.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. rosariocaruso@tin.it","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042484828","display_name":"Giovanni Tuccari","orcid":"https://orcid.org/0000-0002-1561-4246","observed_orcids":["https://orcid.org/0000-0002-1561-4246"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Tuccari","raw_affiliation_strings":["Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. tuccari@unime.it"],"raw_orcid":"https://orcid.org/0000-0002-1561-4246","affiliations":[{"raw_affiliation_string":"Department of Human Pathology \"Gaetano Barresi\", Section of Anatomic Pathology,  University of Messina, Messina 98123, Italy","institution_ids":["https://openalex.org/I112862951"]},{"raw_affiliation_string":"Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina 98123, Italy. tuccari@unime.it","institution_ids":["https://openalex.org/I112862951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042484828"],"corresponding_institution_ids":["https://openalex.org/I112862951"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":3.2868,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.91947238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"22331","last_page":"22341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.22529999911785126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.800000011920929},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/synchronous-metastasis","display_name":"synchronous metastases","score":0.8240000009536743},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.8349999785423279},{"id":"https://openalex.org/keywords/concordance-rate","display_name":"concordance rate","score":0.7329999804496765},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9340000152587891},{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6785963773727417},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.675113320350647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5365042686462402},{"id":"https://openalex.org/C2993220764","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Gastric carcinoma","level":3,"score":0.5003368854522705},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4925328195095062},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.4738519489765167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4600493907928467},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2886251211166382},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.3390/ijms151222331","doi":"https://doi.org/10.3390/ijms151222331","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151222331","pdf_url":"https://www.mdpi.com/1422-0067/15/12/22331/pdf?version=1417600071","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4284711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4284711","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:25479078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25479078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1154238","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1154238","pdf_url":"http://www.mdpi.com/1422-0067/15/12/22331/pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.663.7005","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.663.7005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1422-0067/15/12/22331/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6f839b4b019a44b5967573eb05b8203e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f839b4b019a44b5967573eb05b8203e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22331-22341 (2014)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:de70535e41034ed28c6209bdc365b9b9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/de70535e41034ed28c6209bdc365b9b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22331-22341 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms151222331","doi":"https://doi.org/10.3390/ijms151222331","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151222331","pdf_url":"https://www.mdpi.com/1422-0067/15/12/22331/pdf?version=1417600071","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016283072.pdf","grobid_xml":"https://content.openalex.org/works/W2016283072.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1486586988","https://openalex.org/W1690659936","https://openalex.org/W1969015681","https://openalex.org/W1976323199","https://openalex.org/W1987009448","https://openalex.org/W1992173627","https://openalex.org/W2011666308","https://openalex.org/W2014768527","https://openalex.org/W2015918488","https://openalex.org/W2017176432","https://openalex.org/W2029175285","https://openalex.org/W2040354648","https://openalex.org/W2065798347","https://openalex.org/W2069430564","https://openalex.org/W2072557285","https://openalex.org/W2073155340","https://openalex.org/W2075657881","https://openalex.org/W2078411266","https://openalex.org/W2079975579","https://openalex.org/W2087280735","https://openalex.org/W2098719877","https://openalex.org/W2099117820","https://openalex.org/W2099421298","https://openalex.org/W2104694188","https://openalex.org/W2113233663","https://openalex.org/W2126324838","https://openalex.org/W2132065448","https://openalex.org/W2152940687","https://openalex.org/W2170872221","https://openalex.org/W2313866015","https://openalex.org/W2314556209","https://openalex.org/W2592016744","https://openalex.org/W7074162504"],"related_works":["https://openalex.org/W7098943495","https://openalex.org/W2747765858","https://openalex.org/W2471512801","https://openalex.org/W2017176432","https://openalex.org/W2045657771","https://openalex.org/W2302521998","https://openalex.org/W1988533098","https://openalex.org/W2334852621","https://openalex.org/W2104694188","https://openalex.org/W2071192019"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"assessment":[2],"of":[3,63,69,82,87,100,110,182,202,211,216,230],"human":[4],"epidermal":[5],"growth":[6],"factor":[7],"receptor":[8],"2":[9],"(HER2)":[10],"gene":[11],"amplification":[12,105],"is":[13,193,215],"essential":[14],"in":[15,44,60,85,108,125,137,148,155,164,170,184],"order":[16],"to":[17,39,95],"identify":[18],"those":[19],"patients":[20],"affected":[21],"by":[22],"advanced":[23,185],"gastric":[24,49,186],"cancer":[25,187],"who":[26],"may":[27,221],"benefit":[28],"from":[29,78,209],"Trastuzumab":[30],"targeted":[31],"therapy.":[32],"MATERIALS":[33],"AND":[34],"METHODS:":[35],"With":[36],"the":[37,41,97,114,149,156,165,171,179,196,199,212,225,231],"aim":[38],"investigate":[40],"concordance":[42,98,116],"rate":[43,99,117],"HER2":[45,58,101,104,126,146,161,183,207],"status":[46,59,127,208],"between":[47,128],"primary":[48,111,129,150,166,213],"carcinoma":[50],"(GC)":[51],"and":[52,71,113,131,152,168,188,228],"synchronous":[53,73,133,200],"lymphnode":[54],"metastases,":[55,157],"we":[56],"investigated":[57],"a":[61,205],"cohort":[62],"108":[64],"surgical":[65],"formalin-fixed":[66],"paraffin-embedded":[67],"specimens":[68],"GC":[70,130,151,203],"matched":[72,132],"metastatic":[74,190],"lymph":[75,172,191],"nodes":[76,192],"collected":[77],"three":[79],"different":[80,206],"units":[81],"Anatomic":[83],"Pathology":[84],"southern":[86],"Italy.":[88],"Fleiss-Cohen":[89],"weighted":[90],"k":[91],"statistics":[92],"were":[93,135,145,160],"used":[94],"assess":[96],"status.":[102],"RESULTS:":[103],"was":[106,122],"observed":[107],"17%":[109],"GCs":[112],"overall":[115],"with":[118],"corresponding":[119,189],"nodal":[120],"metastases":[121,134,201],"90.74%.":[123],"Changes":[124],"evidenced":[136],"10":[138],"(9.26%)":[139],"cases.":[140],"Of":[141],"these,":[142],"6":[143],"cases":[144],"amplified":[147,154,163,169],"not":[153,162,194],"while":[158],"4":[159],"tumour":[167,214],"node":[173],"metastases.":[174],"CONCLUSIONS:":[175],"Although":[176],"at":[177],"present":[178],"simultaneous":[180],"determination":[181],"mandatory,":[195],"possibility":[197],"that":[198,210],"have":[204,222],"remarkable":[217],"significance;":[218],"Indeed":[219],"this":[220],"influence":[223],"on":[224],"therapeutic":[226],"management":[227],"prognosis":[229],"patients.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
