{"id":"https://openalex.org/W2016281017","doi":"https://doi.org/10.1097/ana.0b013e3181cd318b","title":"Cerebral Pial Vascular Changes Under Propofol or Sevoflurane Anesthesia During Global Cerebral Ischemia and Reperfusion in Rabbits","display_name":"Cerebral Pial Vascular Changes Under Propofol or Sevoflurane Anesthesia During Global Cerebral Ischemia and Reperfusion in Rabbits","publication_year":2010,"publication_date":"2010-05-18","ids":{"openalex":"https://openalex.org/W2016281017","doi":"https://doi.org/10.1097/ana.0b013e3181cd318b","mag":"2016281017","pmid":"https://pubmed.ncbi.nlm.nih.gov/20118796"},"language":"en","primary_location":{"id":"doi:10.1097/ana.0b013e3181cd318b","doi":"https://doi.org/10.1097/ana.0b013e3181cd318b","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ana.0b013e3181cd318b","pdf_url":null,"source":{"id":"https://openalex.org/S23610305","display_name":"Journal of Neurosurgical Anesthesiology","issn_l":"0898-4921","issn":["0898-4921","1537-1921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgical Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076913560","display_name":"Tadahiko Ishiyama","orcid":"https://orcid.org/0000-0003-2740-1958","observed_orcids":["https://orcid.org/0000-0003-2740-1958"]},"institutions":[{"id":"https://openalex.org/I4210112011","display_name":"University of Yamanashi Hospital","ror":"https://ror.org/022tqjv17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112011"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadahiko Ishiyama","raw_affiliation_strings":["Surgical Center, University of Yamanashi Hospital, Yamanashi, Japan. ishiyama@yamanashi.ac.jp","Surgical Center, University of Yamanashi Hospital, Yamanashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Center, University of Yamanashi Hospital, Yamanashi, Japan. ishiyama@yamanashi.ac.jp","institution_ids":["https://openalex.org/I4210112011"]},{"raw_affiliation_string":"Surgical Center, University of Yamanashi Hospital, Yamanashi, Japan","institution_ids":["https://openalex.org/I4210112011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089984032","display_name":"Kazuhiro Shibuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Shibuya","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","University of Yamanashi#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"University of Yamanashi#TAB#","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026204605","display_name":"Manabu Ichikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253588","display_name":"Fujiyoshida Municipal Medical Center","ror":"https://ror.org/00vmrsn64","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405253588"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Ichikawa","raw_affiliation_strings":["Department of Anesthesia, Fujiyoshida Municipal Hospital","Fujiyoshida Municipal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Fujiyoshida Municipal Hospital","institution_ids":["https://openalex.org/I4405253588"]},{"raw_affiliation_string":"Fujiyoshida Municipal Hospital","institution_ids":["https://openalex.org/I4405253588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021180416","display_name":"Taishi Masamune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taishi Masamune","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","University of Yamanashi#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"University of Yamanashi#TAB#","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042831119","display_name":"Riko KIUCHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riko Kiuchi","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","University of Yamanashi#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"University of Yamanashi#TAB#","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I. Sessler","raw_affiliation_strings":["Department of Outcomes Research, Anesthesiology Institute, The Cleveland Clinic","Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Outcomes Research, Anesthesiology Institute, The Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Anesthesiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100729074","display_name":"Takashi Matsukawa","orcid":"https://orcid.org/0000-0002-5307-5968","observed_orcids":["https://orcid.org/0000-0002-5307-5968"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Matsukawa","raw_affiliation_strings":["Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","University of Yamanashi#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Faculty of Medicine, University of Yamanashi","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"University of Yamanashi#TAB#","institution_ids":["https://openalex.org/I66906201"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076913560"],"corresponding_institution_ids":["https://openalex.org/I4210112011"],"apc_list":null,"apc_paid":null,"fwci":1.2189,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80226397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"3","first_page":"207","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3366999924182892,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3366999924182892,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.21449999511241913,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":0.9990000128746033},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.7630000114440918},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pial-microcirculation","display_name":"pial microcirculation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cerebral-vasodilation","display_name":"cerebral vasodilation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cerebral-vasoconstriction","display_name":"cerebral vasoconstriction","score":0.902999997138977},{"id":"https://openalex.org/keywords/intralipid","display_name":"Intralipid","score":0.875},{"id":"https://openalex.org/keywords/neuroanesthesia","display_name":"neuroanesthesia","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.597000002861023},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9298957586288452},{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.8756128549575806},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.835791826248169},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7907546162605286},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7030457258224487},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5005526542663574},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2043515145778656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17690438032150269}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000771","descriptor_name":"Anesthesia, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002550","descriptor_name":"Cerebral Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005217","descriptor_name":"Fat Emulsions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/ana.0b013e3181cd318b","doi":"https://doi.org/10.1097/ana.0b013e3181cd318b","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ana.0b013e3181cd318b","pdf_url":null,"source":{"id":"https://openalex.org/S23610305","display_name":"Journal of Neurosurgical Anesthesiology","issn_l":"0898-4921","issn":["0898-4921","1537-1921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgical Anesthesiology","raw_type":"journal-article"},{"id":"pmid:20118796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20118796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgical anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1964100686","https://openalex.org/W1969060067","https://openalex.org/W1991289521","https://openalex.org/W2009017153","https://openalex.org/W2021112858","https://openalex.org/W2026399192","https://openalex.org/W2031660763","https://openalex.org/W2047143193","https://openalex.org/W2048205821","https://openalex.org/W2083902120","https://openalex.org/W2085200331","https://openalex.org/W2089133038","https://openalex.org/W2092646401","https://openalex.org/W2094780089","https://openalex.org/W2099312306","https://openalex.org/W2110331881","https://openalex.org/W2128182432"],"related_works":["https://openalex.org/W2021112858","https://openalex.org/W4210481775","https://openalex.org/W2028018676","https://openalex.org/W1970114159","https://openalex.org/W2053533054","https://openalex.org/W2907845708","https://openalex.org/W7046279690","https://openalex.org/W2007305882","https://openalex.org/W2041947606","https://openalex.org/W2393987686"],"abstract_inverted_index":{"BACKGROUND:":[0],"Propofol":[1,201],"and":[2,28,35,53,68,84,95,103,120,131,135,140,161,190,202,216,224,238,242],"sevoflurane":[3,23,46,52,147,170,203],"are":[4],"commonly":[5],"used":[6],"anesthetics":[7],"for":[8,72,97],"neurosurgery.":[9],"The":[10],"aim":[11],"of":[12,20,51,157],"the":[13,18,49,63,113,155,158,169,180,228],"study":[14],"was":[15,59,77,143],"to":[16,165,177,244],"compare":[17],"effects":[19,185],"propofol":[21,44,181],"with":[22,43],"on":[24,206],"cerebral":[25],"pial":[26,118,133,207,236],"arteriolar":[27,119,134],"venular":[29,121,136],"diameters":[30,122,137,167],"during":[31,110,209],"global":[32],"brain":[33,57,192],"ischemia":[34,58,111],"reperfusion.":[36],"METHODS:":[37],"Japanese":[38],"white":[39],"rabbits":[40],"were":[41,91,194],"anesthetized":[42],"(n=11),":[45],"(n=9),":[47],"or":[48],"combination":[50],"intralipid":[54],"(n=10).":[55],"Global":[56],"induced":[60],"by":[61,175],"clamping":[62,94],"brachiocephalic,":[64],"left":[65,69],"common":[66],"carotid,":[67],"subclavian":[70],"arteries":[71],"15":[73],"minutes.":[74,99],"Pial":[75,214],"microcirculation":[76],"observed":[78,144,195],"microscopically":[79],"through":[80],"closed":[81],"cranial":[82],"windows":[83],"measured":[85],"using":[86],"a":[87],"digital-video":[88],"analyzer.":[89],"Measurements":[90],"recorded":[92],"before":[93],"afterward":[96],"120":[98],"RESULTS:":[100],"Plasma":[101],"glucose":[102],"mean":[104],"arterial":[105],"blood":[106],"pressure":[107],"increased":[108,138],"significantly":[109,124,174],"in":[112,125,145,168,179,197,231,246],"propofol-anesthetized":[114,198,232],"rabbits.":[115,182,199,233,248],"During":[116],"ischemia,":[117],"decreased":[123,173],"all":[126],"groups.":[127,148],"After":[128],"unclamping,":[129],"large":[130,160],"small,":[132],"temporarily":[139,241],"significant":[141],"dilation":[142],"both":[146],"From":[149],"10":[150],"minutes":[151],"after":[152,211,222],"unclamping":[153],"until":[154],"end":[156],"study,":[159],"small":[162],"arterioles":[163,215,237],"returned":[164,243],"baseline":[166,245],"groups,":[171],"but":[172],"10%":[176],"20%":[178],"Ischemia-induced":[183],"adverse":[184],"such":[186],"as":[187],"pulmonary":[188],"edema":[189],"acute":[191],"swelling":[193],"primarily":[196],"CONCLUSION:":[200],"acted":[204],"differently":[205],"vessels":[208],"reperfusion":[210,229],"ischemic":[212],"insult.":[213],"venules":[217,239],"did":[218],"not":[219],"dilate":[220],"immediately":[221],"reperfusion,":[223],"subsequently":[225],"constricted":[226],"throughout":[227],"period":[230],"In":[234],"contrast,":[235],"dilated":[240],"sevoflurane-anesthetized":[247]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}