{"id":"https://openalex.org/W2016279303","doi":"https://doi.org/10.1158/1538-7445.am10-lb-54","title":"Abstract LB-54: Interferon targets JAK2V617F positive hematopoietic progenitor cells and acts through the p38 MAP kinase pathway","display_name":"Abstract LB-54: Interferon targets JAK2V617F positive hematopoietic progenitor cells and acts through the p38 MAP kinase pathway","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2016279303","doi":"https://doi.org/10.1158/1538-7445.am10-lb-54","mag":"2016279303"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-lb-54","doi":"https://doi.org/10.1158/1538-7445.am10-lb-54","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-lb-54","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100778170","display_name":"Min L\u00fc","orcid":"https://orcid.org/0000-0002-4191-4787","observed_orcids":["https://orcid.org/0000-0002-4191-4787"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Lu","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102794443","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-3325-6059","observed_orcids":["https://orcid.org/0000-0002-3325-6059"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100600965","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-4883-0092","observed_orcids":["https://orcid.org/0000-0002-4883-0092"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042483525","display_name":"Demitriy Berenzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demitriy Berenzon","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456908","display_name":"Xiaoli Wang","orcid":"https://orcid.org/0000-0002-7198-273X","observed_orcids":["https://orcid.org/0000-0002-7198-273X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoli Wang","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101443360","display_name":"Jiapeng Wang","orcid":"https://orcid.org/0000-0002-9191-8954","observed_orcids":["https://orcid.org/0000-0002-9191-8954"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiapeng Wang","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103440748","display_name":"Pratima Chaurasia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratima Chaurasia","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088605815","display_name":"Jonh Mascarenhas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonh Mascarenhas","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033704013","display_name":"Mingjiang Xu","orcid":"https://orcid.org/0000-0002-7063-6253","observed_orcids":["https://orcid.org/0000-0002-7063-6253"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingjiang Xu","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732","https://orcid.org/0000-0002-0091-9573"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Hoffman","raw_affiliation_strings":["1Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"LB","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9020000100135803},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pegylated-interferon","display_name":"pegylated interferon","score":0.628000020980835},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hematopoietic-colony-formation","display_name":"hematopoietic colony formation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/allele-burden","display_name":"allele burden","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7038351893424988},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7038202881813049},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6721814870834351},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6354157328605652},{"id":"https://openalex.org/C192285135","wikidata":"https://www.wikidata.org/wiki/Q954757","display_name":"Colony-forming unit","level":3,"score":0.585134744644165},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5306543111801147},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4932991564273834},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4305632710456848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3999254107475281},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35393744707107544},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33392563462257385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3303403854370117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07151058316230774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-lb-54","doi":"https://doi.org/10.1158/1538-7445.am10-lb-54","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-lb-54","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097922857","https://openalex.org/W2551601852","https://openalex.org/W2015113479","https://openalex.org/W2564056222","https://openalex.org/W2580278087","https://openalex.org/W2586741499","https://openalex.org/W2909715029","https://openalex.org/W2364744435","https://openalex.org/W2559879605","https://openalex.org/W2033374532"],"abstract_inverted_index":{"Abstract":[0],"Interferon":[1,93],"\u03b1":[2,94,100,107],"(IFN\u03b1)":[3],"has":[4,18],"been":[5,19],"used":[6],"for":[7,213,221,227,233,240,519],"over":[8],"20":[9],"years":[10],"to":[11,24,46,252,279,379],"treat":[12],"patients":[13,38,77],"with":[14,83,255,265,355,447],"MPN,":[15],"recently":[16],"it":[17],"reported":[20],"that":[21,479,492],"IFN\u03b1":[22,53,114,141,160,184],"leads":[23],"hematological":[25],"remissions":[26],"and":[27,71,78,104,148,159,186,196,207,216,236,285,436,470,485,491],"a":[28,129,179,290,388,414],"reduction":[29,292,390],"of":[30,42,75,85,91,113,134,136,140,146,181,204,257,260,268,275,282,296,305,313,322,342,351,363,375,383,396,406,420,440,453,482,510,515],"the":[31,48,72,86,132,137,225,253,294,311,319,364,373,381,397,404,418,441,451,462,467,497,511,516],"JAK2V617F":[32,326,343,368,489],"allele":[33],"burden":[34],"in":[35,58,81,118,128,168,289,293,349,358,361,391,417,457],"most":[36],"PV":[37,59,76,175,214,222,234,241,276,338,458,488],"receiving":[39],"this":[40],"modality":[41],"therapy.":[43],"In":[44,272,394],"order":[45],"evaluate":[47],"cellular":[49,320],"target":[50,321],"by":[51,123,144,174,193,200,473],"which":[52,262,422],"affects":[54],"hematopoietic":[55,120,298,345],"progenitor":[56,299],"cells":[57,62,127,245,278,300,334,411],"patients,":[60],"CD34+":[61,126,176,244,277,333,459],"were":[63,79,162,249,347,371],"isolated":[64],"from":[65,246,335],"cord":[66,247],"blood,":[67],"normal":[68,124],"bone":[69],"marrow":[70,125],"peripheral":[73],"blood":[74,248],"treated":[80,354],"vitro":[82],"each":[84,135,256,395],"three":[87,138,258],"commercially":[88],"available":[89],"forms":[90,139,259],"IFN\u03b1:":[92],"2b":[95,108,161,167,185,206,229,287,307],"(IFN\u03b1":[96],"2b),":[97],"pegylated":[98,105],"interferon":[99,106],"2a":[101,158,188,209,284,324,357,377,402,449],"(Peg-IFN\u03b1":[102,109],"2a)":[103],"2b).":[110],"Each":[111],"form":[112],"was":[115,153,210,237,263,413],"equally":[116],"potent":[117],"suppressing":[119],"colony":[121,151,172,192,199],"formation":[122,152,173],"dose-dependent":[130],"fashion,":[131],"IC50":[133,203,226],"as":[142],"showed":[143],"inhibition":[145,435,469],"CFU-GM":[147,190,215,235],"BFU-E":[149,170,197],"derived":[150,171,191,198],"2000":[154,182,231],"units/ml.":[155],"Interestedly,":[156],"Peg-IFN\u03b1":[157,166],"more":[163],"effective":[164],"than":[165,218],"inhibiting":[169],"cells,":[177,460],"at":[178],"concentration":[180],"units/ml,":[183],"Peg-IFN":[187,208,228,283,306,323,356,376,401,448,474],"diminished":[189],"80":[194],"%":[195],"90%.":[201],"The":[202,340],"IFN":[205,261,269,286,431,483],"200":[211],"units/ml":[212,220,232,239],"less":[217,250],"100":[219],"BFU-E,":[223],"while":[224,302,461],"exceeded":[230],"500":[238],"BFU-E.":[242],"But":[243],"sensitive":[251],"treatment":[254],"correlated":[264],"reduced":[266,348,403],"expression":[267],"receptor":[270],"1.":[271],"addition,":[273],"exposure":[274],"equal":[280],"doses":[281,304,481],"resulted":[288],"38-40%":[291],"proportion":[295],"JAK2V617F-positive":[297],"(HPC),":[301],"equivalent":[303],"did":[308],"not":[309],"reduce":[310],"number":[312,405],"malignant":[314],"HPC.":[315],"To":[316],"further":[317,428],"assess":[318],"on":[325,332],"HPC,":[327],"we":[328],"performed":[329],"similar":[330],"studies":[331],"12":[336,352],"additional":[337],"patients.":[339],"numbers":[341,419],"positive":[344],"colonies":[346,370,386,407,421],"11":[350,398],"cases":[353,366],"vitro.":[359],"Furthermore,":[360],"7":[362],"9":[365],"where":[367,400],"homozygous":[369,385],"observed":[372],"addition":[374],"led":[378],"either":[380],"elimination":[382],"such":[384],"or":[387],"marked":[389],"their":[392],"numbers.":[393],"instances":[399],"containing":[408],"JAK2":[409],"mutated":[410],"there":[412],"concomitant":[415],"increase":[416],"contained":[423],"exclusively":[424],"WT":[425],"JAK2.":[426],"We":[427],"explored":[429],"if":[430],"induces":[432],"HPC":[433,490],"growth":[434,468],"apoptosis":[437,471],"through":[438,496],"activation":[439],"p38":[442,454,498],"MAP":[443,455,499],"kinase":[444,456,500],"pathway.":[445,501],"Treatment":[446],"increased":[450],"phosphorylation/activition":[452],"p38-specific":[463],"inhibitor":[464],"SB203580":[465],"reversed":[466],"induced":[472],"2a.":[475],"These":[476],"data":[477],"suggest":[478],"low":[480],"selectively":[484],"directly":[486],"suppress":[487],"these":[493],"agents":[494],"act":[495],"Citation":[502],"Format:":[503],"{Authors}.":[504],"{Abstract":[505],"title}":[506],"[abstract].":[507],"In:":[508],"Proceedings":[509],"101st":[512],"Annual":[513],"Meeting":[514],"American":[517],"Association":[518],"Cancer":[520,530],"Research;":[521],"2010":[522],"Apr":[523],"17-21;":[524],"Washington,":[525],"DC.":[526],"Philadelphia":[527],"(PA):":[528],"AACR;":[529],"Res":[531],"2010;70(8":[532],"Suppl):Abstract":[533],"nr":[534],"LB-54.":[535]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
