{"id":"https://openalex.org/W2016278325","doi":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","title":"Bitter Taste Receptors and Their Cells","display_name":"Bitter Taste Receptors and Their Cells","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W2016278325","doi":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","mag":"2016278325","pmid":"https://pubmed.ncbi.nlm.nih.gov/19686120"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.2009.03897.x","doi":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024990714","display_name":"Maik Behrens","orcid":"https://orcid.org/0000-0003-2082-8860","observed_orcids":["https://orcid.org/0000-0003-2082-8860"]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maik Behrens","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. behrens@dife.de","Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. behrens@dife.de","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087973719","display_name":"Claudia Reichling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Reichling","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046738312","display_name":"Claudia Batram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Batram","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076819232","display_name":"Anne Brockhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Brockhoff","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009872018","display_name":"Wolfgang Meyerhof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Meyerhof","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024990714"],"corresponding_institution_ids":["https://openalex.org/I4210162705"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":1.5084,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81789639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1170","issue":"1","first_page":"111","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitter-taste-receptors","display_name":"bitter taste receptors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bitter-taste-perception","display_name":"bitter taste perception","score":0.781000018119812},{"id":"https://openalex.org/keywords/plant-metabolites","display_name":"plant metabolites","score":0.7689999938011169},{"id":"https://openalex.org/keywords/receptor-biosynthesis","display_name":"receptor biosynthesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/food-choice","display_name":"food choice","score":0.6029999852180481},{"id":"https://openalex.org/keywords/evolution-of-taste","display_name":"evolution of taste","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C3020017864","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Bitter taste","level":3,"score":0.8105617761611938},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7861350178718567},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6721209287643433},{"id":"https://openalex.org/C19841687","wikidata":"https://www.wikidata.org/wiki/Q18055224","display_name":"GPR120","level":4,"score":0.6248965859413147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.58559650182724},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.5725041031837463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5128824710845947},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.41076159477233887},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.40298256278038025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38520753383636475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34587258100509644},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22050568461418152}],"mesh":[{"descriptor_ui":"D005518","descriptor_name":"Food Preferences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.2009.03897.x","doi":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2009.03897.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:19686120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19686120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1969740257","https://openalex.org/W1970934036","https://openalex.org/W1973693850","https://openalex.org/W1980409809","https://openalex.org/W1983881012","https://openalex.org/W1985101496","https://openalex.org/W1988225036","https://openalex.org/W1988715808","https://openalex.org/W2020562862","https://openalex.org/W2027933054","https://openalex.org/W2045358393","https://openalex.org/W2062801880","https://openalex.org/W2064034213","https://openalex.org/W2066381476","https://openalex.org/W2069096014","https://openalex.org/W2071008461","https://openalex.org/W2071196106","https://openalex.org/W2072794808","https://openalex.org/W2082269792","https://openalex.org/W2089836418","https://openalex.org/W2110147039","https://openalex.org/W2118311495","https://openalex.org/W2126098900","https://openalex.org/W2138727998","https://openalex.org/W2139177655","https://openalex.org/W2159413546","https://openalex.org/W2163165016","https://openalex.org/W2165664061","https://openalex.org/W2169702025","https://openalex.org/W2398343508"],"related_works":["https://openalex.org/W2132540940","https://openalex.org/W1511314781","https://openalex.org/W1542161320","https://openalex.org/W2137311570","https://openalex.org/W2078435302","https://openalex.org/W2071008461","https://openalex.org/W7096072858","https://openalex.org/W1971543781","https://openalex.org/W1972615898","https://openalex.org/W128210498"],"abstract_inverted_index":{"The":[0,72],"molecular":[1],"basis":[2],"of":[3,11,31,37,54,80,90],"human":[4],"bitter":[5,34,45,58],"taste":[6,59],"perception":[7],"is":[8],"an":[9],"area":[10],"intense":[12],"research.":[13],"Only":[14],"25":[15],"G":[16],"protein-coupled":[17],"receptors":[18],"belonging":[19],"to":[20,28],"the":[21,26],"hTAS2R":[22,91],"gene":[23],"family":[24],"face":[25],"challenge":[27],"detect":[29],"thousands":[30],"structurally":[32],"different":[33],"compounds,":[35],"most":[36,66],"which":[38],"are":[39,47,52],"plant":[40],"metabolites.":[41],"Since":[42],"many":[43],"natural":[44],"compounds":[46],"highly":[48],"toxic,":[49],"whereas":[50],"others":[51],"part":[53],"our":[55,69],"daily":[56],"diets,":[57],"was":[60],"crucial":[61],"during":[62],"evolution":[63],"and":[64,82],"still":[65],"likely":[67],"affects":[68],"food":[70],"selection.":[71],"article":[73],"presented":[74],"here":[75],"addresses":[76],"biosynthesis,":[77],"functional":[78],"analyses":[79],"TAS2Rs":[81],"TAS2R":[83],"variants,":[84],"as":[85,87],"well":[86],"gustatory":[88],"expression":[89],"genes.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
