{"id":"https://openalex.org/W2016278165","doi":"https://doi.org/10.1186/1471-2407-14-664","title":"Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers","display_name":"Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers","publication_year":2014,"publication_date":"2014-09-11","ids":{"openalex":"https://openalex.org/W2016278165","doi":"https://doi.org/10.1186/1471-2407-14-664","mag":"2016278165","pmid":"https://pubmed.ncbi.nlm.nih.gov/25213022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4171582"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-14-664","doi":"https://doi.org/10.1186/1471-2407-14-664","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-14-664","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-14-664","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-14-664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100438450","display_name":"Hang Zhang","orcid":"https://orcid.org/0000-0002-2768-492X","observed_orcids":["https://orcid.org/0000-0002-2768-492X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Zhang","raw_affiliation_strings":["Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China","Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031124433","display_name":"Xiyong Liu","orcid":"https://orcid.org/0000-0002-0259-3669","observed_orcids":["https://orcid.org/0000-0002-0259-3669"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiyong Liu","raw_affiliation_strings":["Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058170576","display_name":"Charles Warden","orcid":"https://orcid.org/0000-0002-1827-4486","observed_orcids":["https://orcid.org/0000-0002-1827-4486"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles D Warden","raw_affiliation_strings":["Bioinformatics Core, Department of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","Bioinformatics Core, Department of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Core, Department of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Bioinformatics Core, Department of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109354101","display_name":"Yasheng Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasheng Huang","raw_affiliation_strings":["Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027521220","display_name":"Sofia Loera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofia Loera","raw_affiliation_strings":["Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081487015","display_name":"Lijun Xue","orcid":"https://orcid.org/0009-0006-9498-2835","observed_orcids":["https://orcid.org/0009-0006-9498-2835"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijun Xue","raw_affiliation_strings":["Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018806880","display_name":"Suzhan Zhang","orcid":"https://orcid.org/0000-0003-2031-5424","observed_orcids":["https://orcid.org/0000-0003-2031-5424"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suzhan Zhang","raw_affiliation_strings":["Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China","Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113652607","display_name":"Peiguo G. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peiguo Chu","raw_affiliation_strings":["Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Anatomic Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054897932","display_name":"Shu Sen Zheng","orcid":"https://orcid.org/0000-0002-2521-190X","observed_orcids":["https://orcid.org/0000-0002-2521-190X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shu Zheng","raw_affiliation_strings":["Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, Zhejiang, China. zhengshu@zju.edu.cn","Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, Zhejiang, China. zhengshu@zju.edu.cn","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009104622","display_name":"Yun Yen","orcid":"https://orcid.org/0000-0003-0815-412X","observed_orcids":["https://orcid.org/0000-0003-0815-412X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yun Yen","raw_affiliation_strings":["Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, 1500 E. Duarte Road, 91010, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009104622","https://openalex.org/A5054897932"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210158318","https://openalex.org/I4387156432","https://openalex.org/I76130692"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.2756,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.20532741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"664","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rrm2","display_name":"RRM2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9430000185966492},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/upa","display_name":"uPA","score":0.5950000286102295},{"id":"https://openalex.org/keywords/ribonucleotide-reductase-inhibitors","display_name":"ribonucleotide reductase inhibitors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7627692222595215},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6436224579811096},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5917266607284546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5260804891586304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5241051912307739},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5002725124359131},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46766769886016846},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4614744186401367},{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.44856002926826477},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44595929980278015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35224616527557373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23552143573760986},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.1859753429889679},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07325327396392822}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012262","descriptor_name":"Ribonucleoside Diphosphate Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012262","descriptor_name":"Ribonucleoside Diphosphate Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2407-14-664","doi":"https://doi.org/10.1186/1471-2407-14-664","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-14-664","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-14-664","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3143088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4171582","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25213022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25213022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4171582","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4171582/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-14-664","doi":"https://doi.org/10.1186/1471-2407-14-664","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-14-664","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-14-664","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5019685449","display_name":null,"funder_award_id":"973Program","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"},{"id":"https://openalex.org/G8773661823","display_name":"Drug Development of Ribonucleotide Reductase Inhibitor","funder_award_id":"R01CA127541","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000889907","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA033572","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320327563","display_name":"Major State Basic Research Development Program of China","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016278165.pdf","grobid_xml":"https://content.openalex.org/works/W2016278165.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W99425048","https://openalex.org/W153941392","https://openalex.org/W1491898376","https://openalex.org/W1965654275","https://openalex.org/W1973498530","https://openalex.org/W1976173969","https://openalex.org/W1983271078","https://openalex.org/W1984592335","https://openalex.org/W1985387098","https://openalex.org/W1987777080","https://openalex.org/W1992069532","https://openalex.org/W2000465781","https://openalex.org/W2015700471","https://openalex.org/W2023427658","https://openalex.org/W2025228190","https://openalex.org/W2047179113","https://openalex.org/W2057944226","https://openalex.org/W2063607020","https://openalex.org/W2067833766","https://openalex.org/W2068497347","https://openalex.org/W2073759231","https://openalex.org/W2089995356","https://openalex.org/W2093909277","https://openalex.org/W2096205264","https://openalex.org/W2096361192","https://openalex.org/W2097255042","https://openalex.org/W2105882193","https://openalex.org/W2106714771","https://openalex.org/W2107160082","https://openalex.org/W2108043112","https://openalex.org/W2110936580","https://openalex.org/W2114323702","https://openalex.org/W2116077607","https://openalex.org/W2118413367","https://openalex.org/W2122761469","https://openalex.org/W2124201592","https://openalex.org/W2128613144","https://openalex.org/W2128985829","https://openalex.org/W2130410032","https://openalex.org/W2130598050","https://openalex.org/W2131994307","https://openalex.org/W2132893003","https://openalex.org/W2134393780","https://openalex.org/W2138258443","https://openalex.org/W2145721910","https://openalex.org/W2146384083","https://openalex.org/W2149464340","https://openalex.org/W2150671673","https://openalex.org/W2156711378","https://openalex.org/W2156734818","https://openalex.org/W2157615753","https://openalex.org/W2160450758","https://openalex.org/W2161426850","https://openalex.org/W2161770015","https://openalex.org/W2161817637","https://openalex.org/W2163563958","https://openalex.org/W2224915174","https://openalex.org/W2413781613","https://openalex.org/W4248412843","https://openalex.org/W4256321774"],"related_works":["https://openalex.org/W2329449542","https://openalex.org/W4206759465","https://openalex.org/W2923898584","https://openalex.org/W4200010524","https://openalex.org/W3034114938","https://openalex.org/W2055164947","https://openalex.org/W4220726198","https://openalex.org/W2010935369","https://openalex.org/W1990542495","https://openalex.org/W4307860461"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ribonucleotide":[1],"reductase":[2],"(RR)":[3],"is":[4],"an":[5],"essential":[6],"enzyme":[7],"involved":[8],"in":[9,82,112,146,183,189],"DNA":[10],"synthesis.":[11],"We":[12],"hypothesized":[13],"that":[14,68,80,101,145,153],"RR":[15,173],"subunit":[16],"M2":[17],"(RRM2)":[18],"might":[19],"be":[20,197],"a":[21,55,113,156,198],"novel":[22],"prognostic":[23,117,142,159,200],"and":[24,35,50,89,97,128,169,202],"predictive":[25],"biomarker":[26,160,201],"for":[27,75,161,205],"estrogen":[28],"receptor":[29],"(ER)-negative":[30],"breast":[31,45,57,70,137,148,163,207],"cancers.":[32,149],"METHODS:":[33],"Individual":[34],"pooled":[36,98],"survival":[37,92],"analyses":[38,99],"were":[39,52,72,106],"conducted":[40],"on":[41,54],"six":[42],"independent":[43],"large-scale":[44],"cancer":[46,208],"microarray":[47],"data":[48],"sets;":[49],"findings":[51],"validated":[53],"human":[56],"tissue":[58],"set":[59,64],"(ZJU":[60],"set).":[61],"RESULTS:":[62],"Gene":[63],"enrichment":[65],"analysis":[66,151],"revealed":[67],"RRM2-high":[69],"cancers":[71,164],"significantly":[73,177],"enriched":[74],"expression":[76],"of":[77,119],"gene":[78,126],"sets":[79],"increased":[81,102],"proliferation,":[83],"invasiveness,":[84],"undifferentiation,":[85],"embryonic":[86],"stem/progenitor-like":[87],"phenotypes,":[88],"poor":[90,109],"patient":[91,110],"(p":[93],"<":[94],"0.01).":[95],"Independent":[96],"verified":[100],"RRM2":[103,120,139,154,194],"mRNA":[104,121],"levels":[105],"associated":[107],"with":[108],"outcome":[111],"dose-dependent":[114],"manner.":[115],"The":[116],"power":[118,143],"was":[122,130,155],"comparable":[123],"to":[124,132,181,196],"multiple":[125],"signatures,":[127],"it":[129],"superior":[131],"TNM":[133],"stage.":[134],"In":[135],"ER-negative":[136,162,184,206],"cancers,":[138],"showed":[140],"more":[141,157],"than":[144,165],"ER-positive":[147,190],"Further":[150],"indicated":[152],"accurate":[158],"the":[166,179],"pathoclinical":[167],"indicators":[168],"uPA.":[170],"A":[171],"new":[172],"inhibitor,":[174],"COH29,":[175],"could":[176],"enhance":[178],"chemosensitivity":[180],"doxorubicin":[182],"MDA-MB-231":[185],"cells,":[186],"but":[187],"not":[188],"MCF-7":[191],"cells.":[192],"CONCLUSION:":[193],"appears":[195],"promising":[199],"therapeutic":[203],"target":[204],"patients.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
