{"id":"https://openalex.org/W2016277963","doi":"https://doi.org/10.1042/bj20090265","title":"The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin\u2013glycan interactions at the cell surface","display_name":"The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin\u2013glycan interactions at the cell surface","publication_year":2009,"publication_date":"2009-05-13","ids":{"openalex":"https://openalex.org/W2016277963","doi":"https://doi.org/10.1042/bj20090265","mag":"2016277963","pmid":"https://pubmed.ncbi.nlm.nih.gov/19432560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2708933"},"language":"en","primary_location":{"id":"doi:10.1042/bj20090265","doi":"https://doi.org/10.1042/bj20090265","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20090265","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/bj20090265","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048973709","display_name":"Michelle C. Miller","orcid":"https://orcid.org/0000-0002-7860-5785","observed_orcids":["https://orcid.org/0000-0002-7860-5785"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle\u00a0C. Miller","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063427546","display_name":"Irina V. Nesmelova","orcid":"https://orcid.org/0000-0002-1835-1533","observed_orcids":["https://orcid.org/0000-0002-1835-1533"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina\u00a0V. Nesmelova","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102805416","display_name":"David Platt","orcid":"https://orcid.org/0009-0002-5369-6147","observed_orcids":["https://orcid.org/0009-0002-5369-6147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Platt","raw_affiliation_strings":["Pro-Pharmaceuticals, Inc., 7 Wells Ave., Newton, MA 02459, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pro-Pharmaceuticals, Inc., 7 Wells Ave., Newton, MA 02459, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073128489","display_name":"Anatole A. Klyosov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anatole Klyosov","raw_affiliation_strings":["Pro-Pharmaceuticals, Inc., 7 Wells Ave., Newton, MA 02459, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pro-Pharmaceuticals, Inc., 7 Wells Ave., Newton, MA 02459, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012810451","display_name":"Kevin H. Mayo","orcid":"https://orcid.org/0000-0001-5399-6719","observed_orcids":["https://orcid.org/0000-0001-5399-6719"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin\u00a0H. Mayo","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, U.S.A","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012810451"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":2.7273,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.89971686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"421","issue":"2","first_page":"211","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carbohydrate-binding-domain","display_name":"carbohydrate-binding domain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-surface-glycoconjugates","display_name":"cell surface glycoconjugates","score":0.8040000200271606},{"id":"https://openalex.org/keywords/binding-dissociation-constant","display_name":"binding dissociation constant","score":0.6819999814033508},{"id":"https://openalex.org/keywords/solution-viscosity","display_name":"solution viscosity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7633850574493408},{"id":"https://openalex.org/C156293190","wikidata":"https://www.wikidata.org/wiki/Q83138026","display_name":"Galectin","level":2,"score":0.7376191020011902},{"id":"https://openalex.org/C92381491","wikidata":"https://www.wikidata.org/wiki/Q5747409","display_name":"Heteronuclear molecule","level":3,"score":0.6328985691070557},{"id":"https://openalex.org/C193125475","wikidata":"https://www.wikidata.org/wiki/Q17029192","display_name":"Heteronuclear single quantum coherence spectroscopy","level":3,"score":0.5778908729553223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5685968995094299},{"id":"https://openalex.org/C13426554","wikidata":"https://www.wikidata.org/wiki/Q416019","display_name":"Glycoconjugate","level":2,"score":0.5213678479194641},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4788660705089569},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.4650289714336395},{"id":"https://openalex.org/C34123561","wikidata":"https://www.wikidata.org/wiki/Q6840000","display_name":"Microrheology","level":3,"score":0.43455713987350464},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.42885535955429077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37973952293395996},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3523327708244324},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3270196318626404},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.2176392674446106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16221848130226135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0891103744506836},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007785","descriptor_name":"Lactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20090265","doi":"https://doi.org/10.1042/bj20090265","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20090265","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1627442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2708933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2708933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2708933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:19432560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19432560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj20090265","doi":"https://doi.org/10.1042/bj20090265","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20090265","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2012212510","display_name":"Dibenzofuran-based Anginex Mimetics that Target Galectin-1","funder_award_id":"R01CA096090","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2227669447","display_name":null,"funder_award_id":"CA 096090","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000894526","display_name":"Molecular, Genetic and Cellular Targets of Cancer Training Program","funder_award_id":"T32CA009138","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1499303660","https://openalex.org/W1525328797","https://openalex.org/W1541131175","https://openalex.org/W1813446526","https://openalex.org/W1820309072","https://openalex.org/W1918822473","https://openalex.org/W1977878598","https://openalex.org/W1980993209","https://openalex.org/W1985069430","https://openalex.org/W1989226073","https://openalex.org/W1989731988","https://openalex.org/W1992678792","https://openalex.org/W1997693725","https://openalex.org/W2002651802","https://openalex.org/W2006714159","https://openalex.org/W2009138421","https://openalex.org/W2011843025","https://openalex.org/W2015049954","https://openalex.org/W2037767282","https://openalex.org/W2037821908","https://openalex.org/W2038952850","https://openalex.org/W2043073277","https://openalex.org/W2045138081","https://openalex.org/W2046148841","https://openalex.org/W2059275298","https://openalex.org/W2066251525","https://openalex.org/W2066545420","https://openalex.org/W2066943709","https://openalex.org/W2068507353","https://openalex.org/W2070468129","https://openalex.org/W2073228254","https://openalex.org/W2076192309","https://openalex.org/W2078086734","https://openalex.org/W2080368709","https://openalex.org/W2082176639","https://openalex.org/W2083872101","https://openalex.org/W2086887280","https://openalex.org/W2090280850","https://openalex.org/W2098483493","https://openalex.org/W2100368894","https://openalex.org/W2104046482","https://openalex.org/W2117832286","https://openalex.org/W2126109855","https://openalex.org/W2129399184","https://openalex.org/W2137615007","https://openalex.org/W2144543824","https://openalex.org/W2146634463","https://openalex.org/W2147880213","https://openalex.org/W2148651211","https://openalex.org/W2155654394","https://openalex.org/W2168912979","https://openalex.org/W2169821755","https://openalex.org/W6629972215"],"related_works":["https://openalex.org/W2151431383","https://openalex.org/W2082947258","https://openalex.org/W3185021764","https://openalex.org/W2086946395","https://openalex.org/W2344618578","https://openalex.org/W2145708869","https://openalex.org/W2068772576","https://openalex.org/W2147648317","https://openalex.org/W7135802271","https://openalex.org/W2067074405"],"abstract_inverted_index":{"gal-1":[0,22,40,73,105,112,124,155,204,254,261,282],"(galectin-1)":[1],"mediates":[2],"cell-cell":[3],"and":[4,33,57,113,131,147,167,171,182,268,286,307],"cell-extracellular":[5],"matrix":[6],"adhesion,":[7],"essentially":[8],"by":[9,46,217],"interacting":[10,47],"with":[11,21,48,74,103,158,168],"beta-galactoside-containing":[12],"glycans":[13,51],"of":[14,71,162,177,226,289,303],"cell-surface":[15],"glycoconjugates.":[16],"Although":[17,203],"most":[18],"structural":[19],"studies":[20],"have":[23,308],"investigated":[24],"its":[25],"binding":[26,195,262],"to":[27,67,106,197,263],"simple":[28],"carbohydrates,":[29],"in":[30,55,208,305],"particular":[31],"lactose":[32,198],"N-acetyl-lactosamine,":[34],"this":[35,116],"view":[36],"is":[37,222,244],"limited,":[38],"because":[39],"functions":[41],"at":[42,255],"the":[43,60,69,108,127,143,211,239,249,256,301],"cell":[44,292],"surface":[45,121],"more":[49],"complex":[50,79],"that":[52,84,115,125,134,154,220,248,277],"are":[53,235],"heterogeneous":[54],"size":[56],"composition.":[58],"In":[59,259],"present":[61],"study":[62],"we":[63,246],"used":[64,95],"NMR":[65,101,149],"spectroscopy":[66],"investigate":[68],"interaction":[70],"human":[72],"a":[75,119,137,159,273],"large":[76,120],"(120":[77],"kDa)":[78],"glycan,":[80],"GRG":[81,157,207,234,264],"(galactorhamnogalacturonate":[82],"glycan),":[83],"contains":[85],"non-randomly":[86],"distributed":[87],"mostly":[88],"terminal":[89,231],"beta(1-->4)-linked":[90],"galactose":[91],"side":[92],"chains.":[93],"We":[94],"15N-1H-HSQC":[96],"(heteronuclear":[97],"single":[98],"quantum":[99],"coherence)":[100],"experiments":[102,151],"15N-enriched":[104],"identify":[107],"GRG-binding":[109],"region":[110,117],"on":[111,123,233],"found":[114],"covers":[118],"area":[122],"includes":[126],"quintessential":[128],"lactose-binding":[129,257],"site":[130,135],"runs":[132],"from":[133],"through":[136],"broad":[138],"valley":[139],"or":[140],"cleft":[141],"towards":[142],"dimer":[144],"interface.":[145],"HSQC":[146],"pulsed-field-gradient":[148],"diffusion":[150,288],"also":[152],"show":[153,247],"binds":[156],"gal-1:GRG":[160],"stoichiometry":[161],"about":[163],"5:1":[164],"(or":[165,187],"6:1)":[166],"average":[169],"macroscopic":[170],"microscopic":[172],"equilibrium":[173],"dissociation":[174],"constants":[175],"(Kd)":[176],"8":[178],"x":[179,184,189,200],"10(-6)":[180,185,190,201],"M":[181,186],"40":[183],"48":[188],"M)":[191],"respectively,":[192],"indicating":[193],"stronger":[194],"than":[196,238],"(Kd=520":[199],"M).":[202],"may":[205,278],"bind":[206,253],"various":[209],"ways,":[210],"glycan":[212,274],"can":[213,252],"be":[214],"competed":[215],"for":[216],"lactose,":[218],"suggesting":[219],"there":[221],"one":[223],"major":[224],"mode":[225],"interaction.":[227],"Furthermore,":[228],"even":[229],"though":[230],"motifs":[232],"Gal-beta(1-->4)-Gal":[236,251],"rather":[237],"traditional":[240],"Gal-beta(1-->4)-Glc/GlcNAc":[241],"(where":[242],"GlcNAc":[243],"N-acetylglucosamine),":[245],"disaccharide":[250],"domain.":[258],"addition,":[260],"disrupts":[265],"inter-glycan":[266],"interactions":[267],"decreases":[269],"glycan-mediated":[270],"solution":[271],"viscosity,":[272],"decongestion":[275],"effect":[276],"help":[279],"explain":[280],"why":[281],"promotes":[283],"membrane":[284],"fluidity":[285],"lateral":[287],"glycoconjugates":[290],"within":[291],"membranes.":[293],"Overall,":[294],"our":[295],"results":[296],"provide":[297],"an":[298],"insight":[299],"into":[300],"function":[302],"galectin":[304],"situ":[306],"potential":[309],"significant":[310],"biological":[311],"consequences.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
