{"id":"https://openalex.org/W2016270454","doi":"https://doi.org/10.1620/tjem.168.427","title":"Chemotherapy in Small Cell Lung Cancer. From View Point of Dose Intensity.","display_name":"Chemotherapy in Small Cell Lung Cancer. From View Point of Dose Intensity.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2016270454","doi":"https://doi.org/10.1620/tjem.168.427","mag":"2016270454","pmid":"https://pubmed.ncbi.nlm.nih.gov/1339106"},"language":"en","primary_location":{"id":"doi:10.1620/tjem.168.427","doi":"https://doi.org/10.1620/tjem.168.427","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.168.427","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/168/2/168_2_427/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tjem1920/168/2/168_2_427/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111891554","display_name":"Yushi Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUSHI NAKAI","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065418556","display_name":"Sadahiro Koinumaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SADAHIRO KOINUMARU","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111451849","display_name":"Shuji Suzuki","orcid":"https://orcid.org/0000-0003-3924-0215","observed_orcids":["https://orcid.org/0000-0003-3924-0215"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHUJI SUZUKI","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021847362","display_name":"Junichi Saito","orcid":"https://orcid.org/0000-0002-4297-727X","observed_orcids":["https://orcid.org/0000-0002-4297-727X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JUNICHI SAITO","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080846994","display_name":"Shunichi Sugawara","orcid":"https://orcid.org/0000-0002-3427-4558","observed_orcids":["https://orcid.org/0000-0002-3427-4558"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHUNICHI SUGAWARA","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260366","display_name":"Yuka Numata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUKA NUMATA","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113729682","display_name":"Joji Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JOJI SATO","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113456522","display_name":"Nobuyuki Matsubara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NOBUYUKI MATSUBARA","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044249804","display_name":"Masakichi Motomiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAKICHI MOTOMIYA","raw_affiliation_strings":["Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depamtment of Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"168","issue":"2","first_page":"427","last_page":"430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dose-intensity","display_name":"dose intensity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8690000176429749},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6669999957084656},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.5839999914169312},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6100730895996094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6021668910980225},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.587300181388855},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.5553398728370667},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.548723578453064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37228232622146606},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12014836072921753},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.050065070390701294}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1620/tjem.168.427","doi":"https://doi.org/10.1620/tjem.168.427","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.168.427","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/168/2/168_2_427/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:1339106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1339106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1620/tjem.168.427","doi":"https://doi.org/10.1620/tjem.168.427","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.168.427","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/168/2/168_2_427/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016270454.pdf","grobid_xml":"https://content.openalex.org/works/W2016270454.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W13341330","https://openalex.org/W580919713","https://openalex.org/W2097597328","https://openalex.org/W2268029867","https://openalex.org/W2413853954","https://openalex.org/W4248237164"],"related_works":["https://openalex.org/W7098357645","https://openalex.org/W2123581060","https://openalex.org/W1984053831","https://openalex.org/W766093639","https://openalex.org/W2417214975","https://openalex.org/W1991728143","https://openalex.org/W2410797389","https://openalex.org/W2040823504","https://openalex.org/W2084568415","https://openalex.org/W1961129053"],"abstract_inverted_index":{"NAKAI,":[0],"Y.,":[1,11],"KOINUMARU,":[2],"S.,":[3,5,9],"SUZUKI,":[4],"SAITO,":[6],"J.,":[7,13],"SUGAWARA,":[8],"NUMATA,":[10],"SATO,":[12],"MATSUBARA,":[14],"N.":[15],"and":[16,97,104,133,141],"MOTOMIYA,":[17],"M.":[18],"Chemotherapy":[19],"in":[20,159,170],"Small":[21],"Cell":[22],"Lung":[23],"Cancer":[24],"-":[25,32,41,173],"From":[26],"View":[27],"Point":[28],"of":[29,43,63,68,78,82,88,95,99,149,167],"Dose":[30],"Intensity":[31],"Tohoku":[33],"J.":[34],"Exp.":[35],"Med.,":[36],"1992,":[37],"168":[38],"(2),":[39],"427-430":[40],"Results":[42],"chemotherapy":[44],"trials":[45],"for":[46,53,106,164],"small":[47,174],"cell":[48,175],"lung":[49,176],"cancer":[50],"carried":[51],"out":[52],"the":[54,107,113,153,168],"past":[55],"5":[56],"years":[57],"were":[58],"analyzed":[59],"from":[60],"view":[61],"point":[62],"dose":[64,103,119,150,179],"intensity.":[65],"Early":[66],"study":[67],"CDDP+EP+ADM":[69],"(1985":[70],"to":[71,112,128],"1987)":[72],"showed":[73,92],"moderate":[74],"response":[75],"rate":[76],"(RR)":[77],"72%":[79],"with":[80,138],"MST":[81,98],"369":[83],"days.":[84],"Succeeding":[85],"alternative":[86],"protocol":[87,123],"CDDP+EP+":[89],"VCR/CPM+ADM+MTX":[90],"(1989-1990)":[91],"improved":[93],"RR":[94,140],"88%":[96],"13":[100],"months.":[101],"Actual":[102],"interval":[105],"alternating":[108],"regiman":[109],"was":[110,131,136],"superior":[111],"single":[114],"arm":[115],"regimen.":[116],"Projected":[117],"relative":[118],"intensity":[120,151,180],"against":[121],"MAOP":[122],"including":[124],"6":[125],"drugs":[126],"common":[127],"our":[129],"regimen":[130],"0.86":[132],"delivered":[134],"RDI":[135],"0.61":[137],"comparable":[139],"MST.":[142],"The":[143],"results":[144],"may":[145],"indicate":[146],"that":[147],"change":[148],"within":[152],"conventional":[154],"renge":[155],"does":[156],"not":[157],"result":[158],"major":[160],"advantage":[161],"or":[162],"disadvantage":[163],"substantial":[165],"prolongation":[166],"survival":[169],"SCLC":[171],"patients.":[172],"cancer;":[177],"chemotherapy;":[178]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
