{"id":"https://openalex.org/W2016267269","doi":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","title":"SLOW HYPERFIBRINOGENAEMIC ACTION OF ADRENALINE AND RELATED SUBSTANCES","display_name":"SLOW HYPERFIBRINOGENAEMIC ACTION OF ADRENALINE AND RELATED SUBSTANCES","publication_year":1956,"publication_date":"1956-06-01","ids":{"openalex":"https://openalex.org/W2016267269","doi":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","mag":"2016267269","pmid":"https://pubmed.ncbi.nlm.nih.gov/13329321","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1509574"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1956.tb01035.x","doi":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1956.tb01035.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1956.tb01035.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082473060","display_name":"Samuel B. Henriques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S. B. HENRIQUES","raw_affiliation_strings":["Institute Butantan, Sa\u0303o Paulo, Brazil","Institute Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Butantan, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Institute Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072572110","display_name":"Olga B. Henriques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"OLGA B. HENRIQUES","raw_affiliation_strings":["Institute Butantan, Sa\u0303o Paulo, Brazil","Institute Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Butantan, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Institute Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002379439","display_name":"Alfredo Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"ALFREDO LEVY","raw_affiliation_strings":["Institute Butantan, Sa\u0303o Paulo, Brazil","Institute Butantan, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Butantan, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Institute Butantan, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800423888"],"apc_list":null,"apc_paid":null,"fwci":0.8099,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.7296581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"2","first_page":"99","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hyperfibrinogenemia","display_name":"hyperfibrinogenemia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sympathomimetic-amines","display_name":"sympathomimetic amines","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tolazoline","display_name":"tolazoline","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5920000076293945},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.46155405044555664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4206479489803314},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1588495373725891},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003029","descriptor_name":"Coagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1956.tb01035.x","doi":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1956.tb01035.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:13329321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13329321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1509574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1509574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol Chemother","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1956.tb01035.x","doi":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1956.tb01035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1956.tb01035.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016267269.pdf","grobid_xml":"https://content.openalex.org/works/W2016267269.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W118420144","https://openalex.org/W138994926","https://openalex.org/W1479683801","https://openalex.org/W1533179050","https://openalex.org/W1537985181","https://openalex.org/W1638288662","https://openalex.org/W1687380620","https://openalex.org/W1964296684","https://openalex.org/W2008342433","https://openalex.org/W2026508694","https://openalex.org/W2032414191","https://openalex.org/W2035823313","https://openalex.org/W2048975988","https://openalex.org/W2054080856","https://openalex.org/W2069143100","https://openalex.org/W2082663914","https://openalex.org/W2089206013","https://openalex.org/W2094702217","https://openalex.org/W2267283293","https://openalex.org/W2281938476","https://openalex.org/W2300408450","https://openalex.org/W2313225520","https://openalex.org/W2313281211","https://openalex.org/W2313446118","https://openalex.org/W2331461328","https://openalex.org/W2335207921","https://openalex.org/W2356126466","https://openalex.org/W2403959431","https://openalex.org/W2414135427","https://openalex.org/W2419929130"],"related_works":["https://openalex.org/W1659123133","https://openalex.org/W2001134114","https://openalex.org/W2073944847","https://openalex.org/W2008919050","https://openalex.org/W2195580095","https://openalex.org/W2018426610","https://openalex.org/W2328314152","https://openalex.org/W2415004376","https://openalex.org/W2022104593","https://openalex.org/W2464110048"],"abstract_inverted_index":{"A":[0],"single":[1],"subcutaneous":[2],"injection":[3,73],"of":[4,12,29,42,56,115,124,159,171,183,188],"adrenaline":[5,125,142],"produces":[6],"a":[7,53,112,118,136],"rise":[8,23,114],"in":[9,15,32,96,139],"the":[10,16,27,30,33,79,97,122,152,163,176,184],"concentration":[11],"plasma":[13,116],"fibrinogen":[14,57,117,160],"rat":[17],"(Henriques,":[18],"Henriques,":[19,88,89],"and":[20,74,90,101,105,108,131,157,168,174],"Mattos,":[21],"1950).This":[22],"is":[24],"proportional":[25],"to":[26,77,126,144],"logarithm":[28],"dose":[31,41],"range":[34],"12.5-200":[35],"ttg./":[36],"100":[37,45],"g.":[38],"body":[39],"weight.A":[40],"50":[43],"or":[44,49,67,128],"ptg.adrenaline,":[46],"given":[47],"subcutaneously":[48],"intraperiton-":[50],"eally,":[51],"caused":[52],"marked":[54],"increase":[55,138],"24":[58],"hr.later,":[59],"but":[60],"no":[61],"change":[62],"was":[63],"detected":[64],"1,":[65],"2,":[66],"4":[68],"hr.after":[69],"administration.This":[70],"lag":[71],"between":[72,155,165],"response":[75],"seems":[76],"distinguish":[78],"pheno-":[80],"menon-which":[81],"had":[82],"also":[83],"been":[84],"reported":[85,111,135],"briefly":[86],"by":[87,178],"Selye":[91],"(1950)-from":[92],"similar":[93],"results":[94],"recorded":[95],"earlier":[98],"literature.Thus,":[99],"Riecker":[100],"Winters":[102],"(1931),":[103],"Goreczky":[104],"Kovats":[106],"(1942),":[107],"Suto-Nagy":[109],"(1944)":[110],"transitory":[113],"few":[119],"minutes":[120],"after":[121,141],"administration":[123,143],"dogs":[127],"men.Biggs,":[129],"MacFarlane,":[130],"Pilling":[132],"(1947)":[133],"have":[134],"transient":[137],"fibrinolysis":[140],"human":[145],"subjects.":[146],"This":[147],"paper":[148],"describes":[149],"experiments":[150],"on":[151,162,175],"time-":[153],"relation":[154,164],"treatment":[156],"appearance":[158],"increase,":[161],"chemical":[166],"structure":[167],"hyperfibrinogenaemic":[169],"action":[170],"sympathomimetic":[172],"amines,":[173],"blocking":[177],"tolazoline":[179],"(\"":[180],"Priscol":[181],"\")":[182],"hyper-":[185],"fibrinogenaemic":[186],"effect":[187],"adrenaline.":[189]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}