{"id":"https://openalex.org/W2016267087","doi":"https://doi.org/10.1016/j.bbcan.2009.08.001","title":"Trop2: A possible therapeutic target for late stage epithelial carcinomas","display_name":"Trop2: A possible therapeutic target for late stage epithelial carcinomas","publication_year":2009,"publication_date":"2009-08-20","ids":{"openalex":"https://openalex.org/W2016267087","doi":"https://doi.org/10.1016/j.bbcan.2009.08.001","mag":"2016267087","pmid":"https://pubmed.ncbi.nlm.nih.gov/19683559"},"language":"fr","primary_location":{"id":"doi:10.1016/j.bbcan.2009.08.001","doi":"https://doi.org/10.1016/j.bbcan.2009.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2009.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076232585","display_name":"Rafael A. Cubas","orcid":"https://orcid.org/0000-0002-3450-9054","observed_orcids":["https://orcid.org/0000-0002-3450-9054"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael Cubas","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400752","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-7113-2700","observed_orcids":["https://orcid.org/0000-0002-7113-2700","https://orcid.org/0000-0002-5551-0134","https://orcid.org/0009-0008-7671-1462","https://orcid.org/0000-0001-7093-4931"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108098298","display_name":"Changyi Chen","orcid":"https://orcid.org/0009-0006-1718-4717","observed_orcids":["https://orcid.org/0009-0006-1718-4717"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changyi Chen","raw_affiliation_strings":["Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038846608","display_name":"Qizhi Cathy Yao","orcid":"https://orcid.org/0000-0002-2267-0588","observed_orcids":["https://orcid.org/0000-0002-2267-0588"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qizhi Yao","raw_affiliation_strings":["Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":5070,"currency":"USD","value_usd":5070},"apc_paid":null,"fwci":0.7004,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.61292614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"1796","issue":"2","first_page":"309","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.12710000574588776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trop2","display_name":"TROP2","score":0.972000002861023},{"id":"https://openalex.org/keywords/epithelial-cancers","display_name":"epithelial cancers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cell-surface-glycoproteins","display_name":"cell surface glycoproteins","score":0.847000002861023},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6980000138282776},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9710000157356262},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/oncogene-overexpression","display_name":"oncogene overexpression","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6309999823570251},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.715207040309906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.594806432723999},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5714240074157715},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4944624900817871},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4871234893798828},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4504658579826355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4480232000350952},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.42877334356307983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.398263156414032},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34274232387542725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33208954334259033},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.11931118369102478},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10086536407470703}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019940","descriptor_name":"Genes, bcl-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbcan.2009.08.001","doi":"https://doi.org/10.1016/j.bbcan.2009.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2009.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},{"id":"pmid:19683559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19683559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1503981888","https://openalex.org/W1519776165","https://openalex.org/W1536036565","https://openalex.org/W1771096450","https://openalex.org/W1963537211","https://openalex.org/W1969519743","https://openalex.org/W1974888985","https://openalex.org/W1981203968","https://openalex.org/W1981943594","https://openalex.org/W1984484474","https://openalex.org/W1984640799","https://openalex.org/W1988835634","https://openalex.org/W1991550920","https://openalex.org/W1993127658","https://openalex.org/W2001868206","https://openalex.org/W2004671563","https://openalex.org/W2010747774","https://openalex.org/W2035276752","https://openalex.org/W2038127214","https://openalex.org/W2040605299","https://openalex.org/W2040719899","https://openalex.org/W2041678634","https://openalex.org/W2045306661","https://openalex.org/W2070665737","https://openalex.org/W2078825790","https://openalex.org/W2091732735","https://openalex.org/W2091994251","https://openalex.org/W2095432971","https://openalex.org/W2107166597","https://openalex.org/W2111185851","https://openalex.org/W2111708038","https://openalex.org/W2113275925","https://openalex.org/W2122114596","https://openalex.org/W2133847945","https://openalex.org/W2136044635","https://openalex.org/W2136575012","https://openalex.org/W2137143355","https://openalex.org/W2139721288","https://openalex.org/W2141091746","https://openalex.org/W2144763569","https://openalex.org/W2151238743","https://openalex.org/W2152576610","https://openalex.org/W2152898182","https://openalex.org/W2153482320","https://openalex.org/W2154415145","https://openalex.org/W2155073223","https://openalex.org/W2155921154","https://openalex.org/W2158741313","https://openalex.org/W2166278863","https://openalex.org/W2167390326","https://openalex.org/W2168537923","https://openalex.org/W2170770186","https://openalex.org/W2435309923","https://openalex.org/W4249877820","https://openalex.org/W6718173230"],"related_works":["https://openalex.org/W2188271125","https://openalex.org/W2113922475","https://openalex.org/W1458478781","https://openalex.org/W2340108548","https://openalex.org/W2948651496","https://openalex.org/W2405364537","https://openalex.org/W2590991207","https://openalex.org/W4387402159","https://openalex.org/W3150547156","https://openalex.org/W2091318841"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}