{"id":"https://openalex.org/W2016265973","doi":"https://doi.org/10.1021/jm050280z","title":"Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT2Receptor Affinity","display_name":"Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT2Receptor Affinity","publication_year":2005,"publication_date":"2005-09-23","ids":{"openalex":"https://openalex.org/W2016265973","doi":"https://doi.org/10.1021/jm050280z","mag":"2016265973","pmid":"https://pubmed.ncbi.nlm.nih.gov/16220978"},"language":"en","primary_location":{"id":"doi:10.1021/jm050280z","doi":"https://doi.org/10.1021/jm050280z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm050280z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058195012","display_name":"Jennie Georgsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Jennie Georgsson","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046352749","display_name":"Christian Sk\u00f6ld","orcid":"https://orcid.org/0000-0001-5235-2559","observed_orcids":["https://orcid.org/0000-0001-5235-2559"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Christian Sk\u00f6ld","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015789210","display_name":"Bianca Plouffe","orcid":"https://orcid.org/0000-0002-8321-0796","observed_orcids":["https://orcid.org/0000-0002-8321-0796"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Bianca Plouffe","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110620719","display_name":"Gunnar Lindeberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Gunnar Lindeberg","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086713415","display_name":"Milad Botros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Milad Botros","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008347976","display_name":"Mats Larhed","orcid":"https://orcid.org/0000-0001-6258-0635","observed_orcids":["https://orcid.org/0000-0001-6258-0635"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Mats Larhed","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037716681","display_name":"Fred Nyberg","orcid":"https://orcid.org/0000-0002-7142-3479","observed_orcids":["https://orcid.org/0000-0002-7142-3479"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Fred Nyberg","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091477954","display_name":"Nicole Gallo\u2010Payet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":true,"raw_author_name":"Nicole Gallo-Payet","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047841423","display_name":"Adolf Gogoll","orcid":"https://orcid.org/0000-0002-9092-261X","observed_orcids":["https://orcid.org/0000-0002-9092-261X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Adolf Gogoll","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018815339","display_name":"Anders Karl\u00e9n","orcid":"https://orcid.org/0000-0001-9512-6981","observed_orcids":["https://orcid.org/0000-0001-9512-6981"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":false,"raw_author_name":"Anders Karl\u00e9n","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108389244","display_name":"Anders Hallberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA","SE"],"is_corresponding":true,"raw_author_name":"Anders Hallberg","raw_affiliation_strings":["Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden, Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada, Department of Pharmaceutical Sciences, Division of Biological Research on Drug Dependence, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden, and Department of Chemistry, Organic Chemistry, Uppsala University, P.O. Box 599, SE-751 24 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091477954","https://openalex.org/A5108389244"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I135117807"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.7154,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.81022201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"21","first_page":"6620","last_page":"6631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9399999976158142},{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pseudopeptides","display_name":"pseudopeptides","score":0.7459999918937683},{"id":"https://openalex.org/keywords/receptor-agonists","display_name":"receptor agonists","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.902999997138977},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5839999914169312},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.6159999966621399},{"id":"https://openalex.org/keywords/angiotensin-ii-analogues","display_name":"angiotensin II analogues","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9104764461517334},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6882638335227966},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6799478530883789},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.6424563527107239},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5942249894142151},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4796024560928345},{"id":"https://openalex.org/C38533456","wikidata":"https://www.wikidata.org/wiki/Q1671589","display_name":"Intrinsic activity","level":4,"score":0.4745683968067169},{"id":"https://openalex.org/C2777691172","wikidata":"https://www.wikidata.org/wiki/Q2270","display_name":"Benzene","level":2,"score":0.4547329545021057},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.4491288363933563},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.4119235873222351},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34933221340179443},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.34619176387786865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26125383377075195},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08090880513191223}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm050280z","doi":"https://doi.org/10.1021/jm050280z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm050280z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:16220978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16220978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W255489331","https://openalex.org/W1527240164","https://openalex.org/W1591510379","https://openalex.org/W1856525149","https://openalex.org/W1935853419","https://openalex.org/W1940298558","https://openalex.org/W1965234607","https://openalex.org/W1965599418","https://openalex.org/W1971410991","https://openalex.org/W1973610173","https://openalex.org/W1974814786","https://openalex.org/W1976088649","https://openalex.org/W1980878008","https://openalex.org/W1982116062","https://openalex.org/W1985314662","https://openalex.org/W1989520807","https://openalex.org/W2005288968","https://openalex.org/W2005730386","https://openalex.org/W2007861988","https://openalex.org/W2012853816","https://openalex.org/W2016141901","https://openalex.org/W2021299691","https://openalex.org/W2021477328","https://openalex.org/W2022352256","https://openalex.org/W2024275778","https://openalex.org/W2029424515","https://openalex.org/W2032267105","https://openalex.org/W2039969698","https://openalex.org/W2040400809","https://openalex.org/W2040946407","https://openalex.org/W2042771012","https://openalex.org/W2046259472","https://openalex.org/W2046311259","https://openalex.org/W2046906382","https://openalex.org/W2047730466","https://openalex.org/W2049443318","https://openalex.org/W2050062150","https://openalex.org/W2053539431","https://openalex.org/W2057750448","https://openalex.org/W2067224374","https://openalex.org/W2067946831","https://openalex.org/W2074631079","https://openalex.org/W2076155814","https://openalex.org/W2076311301","https://openalex.org/W2091606377","https://openalex.org/W2092811944","https://openalex.org/W2092923062","https://openalex.org/W2095139673","https://openalex.org/W2115145235","https://openalex.org/W2122167307","https://openalex.org/W2130479394","https://openalex.org/W2131124255","https://openalex.org/W2134899427","https://openalex.org/W2137995988","https://openalex.org/W2143118993","https://openalex.org/W2145879452","https://openalex.org/W2168211076","https://openalex.org/W2176519340","https://openalex.org/W2225340993","https://openalex.org/W2330644927","https://openalex.org/W2334470593","https://openalex.org/W2419273144","https://openalex.org/W2520864089"],"related_works":["https://openalex.org/W2032267105","https://openalex.org/W2069616965","https://openalex.org/W2157846694","https://openalex.org/W2054962424","https://openalex.org/W572588325","https://openalex.org/W1980580174","https://openalex.org/W2095139673","https://openalex.org/W1965234607","https://openalex.org/W7064996632","https://openalex.org/W2096091888"],"abstract_inverted_index":{"Two":[0],"1,3,5-trisubstituted":[1,140],"aromatic":[2],"scaffolds":[3],"intended":[4],"to":[5],"serve":[6],"as":[7,113,150],"gamma-turn":[8,151],"mimetics":[9],"have":[10],"been":[11],"synthesized":[12],"and":[13,147],"incorporated":[14],"in":[15,76,89],"five":[16],"pseudopeptide":[17,71],"analogues":[18],"of":[19,47],"angiotensin":[20,133],"II":[21,134],"(Asp-Arg-Val-Tyr-Ile-His-Pro-Phe),":[22],"replacing":[23],"Val-Tyr-Ile,":[24],"Val-Tyr,":[25],"or":[26],"Tyr-Ile.":[27],"All":[28],"the":[29,36,40,63,98,103,110,139],"tested":[30],"compounds":[31],"exhibited":[32,59],"nanomolar":[33],"affinity":[34,61,118],"for":[35,62,119,128],"AT2":[37,53,78,111,129],"receptor":[38,65,79,92,112,130],"with":[39,109,116],"best":[41],"compound":[42],"(3)":[43],"having":[44],"a":[45],"K(i)":[46],"1.85":[48],"nM.":[49],"Four":[50],"pseudopeptides":[51],"were":[52],"selective,":[54],"while":[55],"one":[56],"(5)":[57],"also":[58],"good":[60],"AT1":[64,91],"(K(i)":[66],"=":[67],"30.3":[68],"nM).":[69],"This":[70],"exerted":[72],"full":[73],"agonistic":[74,87],"activity":[75],"an":[77,90],"induced":[80],"neurite":[81],"outgrowth":[82],"assay":[83],"but":[84],"displayed":[85],"no":[86],"effect":[88],"functional":[93],"assay.":[94],"Molecular":[95],"modeling,":[96],"using":[97],"program":[99],"DISCOtech,":[100],"showed":[101],"that":[102,138],"high-affinity":[104],"ligands":[105,115],"could":[106],"interact":[107],"similarly":[108],"other":[114],"high":[117],"this":[120],"receptor.":[121],"A":[122],"tentative":[123],"agonist":[124],"model":[125],"is":[126],"proposed":[127],"activation":[131],"by":[132],"analogues.":[135],"We":[136],"conclude":[137],"benzene":[141],"rings":[142],"can":[143],"be":[144],"conveniently":[145],"prepared":[146],"are":[148],"suitable":[149],"mimics.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}