{"id":"https://openalex.org/W2016262559","doi":"https://doi.org/10.1371/journal.pone.0117130","title":"Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons","display_name":"Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2016262559","doi":"https://doi.org/10.1371/journal.pone.0117130","mag":"2016262559","pmid":"https://pubmed.ncbi.nlm.nih.gov/25647668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315522"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0117130","doi":"https://doi.org/10.1371/journal.pone.0117130","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117130","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117130&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117130&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072689649","display_name":"Jamil Kanaani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamil Kanaani","raw_affiliation_strings":["Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069797655","display_name":"Chiara Cianciaruso","orcid":"https://orcid.org/0000-0002-5635-5404","observed_orcids":["https://orcid.org/0000-0002-5635-5404"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Chiara Cianciaruso","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030187984","display_name":"Edward A. Phelps","orcid":"https://orcid.org/0000-0001-8666-805X","observed_orcids":["https://orcid.org/0000-0001-8666-805X"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Edward A. Phelps","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001243619","display_name":"Miriella C. Pasquier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Miriella Pasquier","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021374234","display_name":"Estelle Brioudes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Estelle Brioudes","raw_affiliation_strings":["Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009299658","display_name":"Nils Billestrup","orcid":"https://orcid.org/0000-0002-4968-8067","observed_orcids":["https://orcid.org/0000-0002-4968-8067"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nils Billestrup","raw_affiliation_strings":["Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051895672","display_name":"Steinunn B\u00e6kkeskov","orcid":"https://orcid.org/0000-0003-0878-3188","observed_orcids":["https://orcid.org/0000-0003-0878-3188"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Steinunn Baekkeskov","raw_affiliation_strings":["Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America; Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America","Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America; Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I5124864"]},{"raw_affiliation_string":"Departments of Medicine and Microbiology/Immunology, Diabetes Center, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051895672"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I5124864"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.3577,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.94439848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"e0117130","last_page":"e0117130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-synthesis","display_name":"GABA synthesis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gad65","display_name":"GAD65","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gad67","display_name":"GAD67","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9539999961853027},{"id":"https://openalex.org/keywords/golgi-membranes","display_name":"Golgi membranes","score":0.7260000109672546},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7609999775886536},{"id":"https://openalex.org/keywords/insulinoma-cells","display_name":"insulinoma cells","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gaba-signaling","display_name":"GABA signaling","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6758249402046204},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.6645307540893555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.561112642288208},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.5603604912757874},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.4658210277557373},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.4444708228111267},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4349602460861206},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4333811402320862},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.4309208393096924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34037768840789795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32188138365745544},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19070354104042053},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.17704936861991882},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.15425017476081848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12848806381225586},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1371/journal.pone.0117130","doi":"https://doi.org/10.1371/journal.pone.0117130","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117130","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117130&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3292298","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4315522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25647668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25647668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/776db649-b170-48bc-b348-210361e6dee7","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/776db649-b170-48bc-b348-210361e6dee7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kanaani, J, Cianciaruso, C, Phelps, E A, Pasquier, M, Brioudes, E, Billestrup, N & Baekkeskov, S 2015, 'Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons', PLOS ONE, vol. 10, no. 2, e0117130, pp. 1-24. https://doi.org/10.1371/journal.pone.0117130","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:90598","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:90598","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1932-6203","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.5571","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.5571","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ac/35/pone.0117130.PMC4315522.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:54cfc48a6fce459f8a64f05cd627b1de","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/54cfc48a6fce459f8a64f05cd627b1de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 2, p e0117130 (2015)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt45t7z94w","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/45t7z94w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1300810","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Compartmentalization_of_GABA_Synthesis_by_GAD67_Differs_between_Pancreatic_Beta_Cells_and_Neurons_/1300810","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:infoscience.epfl.ch:208539","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/208539","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:208539","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/208539","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:unige.ch:unige:90598","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:90598","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1932-6203","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:qt45t7z94w","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/45t7z94w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Baekkeskov, Steinunn; Kanaani, J; Cianciaruso, C; Phelps, EA; Pasquier, M; Brioudes, E; \u00c2\u00a0et al.(2015). Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/45t7z94w","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0117130","doi":"https://doi.org/10.1371/journal.pone.0117130","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117130","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117130&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8725134716","display_name":"Diabetes Research Center","funder_award_id":"P30DK063720","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320317828","display_name":"Nora Eccles Treadwell Foundation","ror":"https://ror.org/028zcv790"},{"id":"https://openalex.org/F4320321068","display_name":"Ministeriet for Forskning Innovation og Videreg\u00e5ende Uddannelser","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320326860","display_name":"East China Institute of Technology","ror":"https://ror.org/027385r44"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016262559.pdf","grobid_xml":"https://content.openalex.org/works/W2016262559.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1483887312","https://openalex.org/W1546683674","https://openalex.org/W1865343003","https://openalex.org/W1929987752","https://openalex.org/W1964948396","https://openalex.org/W1977392097","https://openalex.org/W1978439344","https://openalex.org/W1978885851","https://openalex.org/W1982898602","https://openalex.org/W1983520891","https://openalex.org/W1987913280","https://openalex.org/W1989582790","https://openalex.org/W1993062686","https://openalex.org/W2006376420","https://openalex.org/W2010554726","https://openalex.org/W2012044970","https://openalex.org/W2020287924","https://openalex.org/W2020527941","https://openalex.org/W2020991754","https://openalex.org/W2022424210","https://openalex.org/W2027619860","https://openalex.org/W2029559333","https://openalex.org/W2031375592","https://openalex.org/W2041412815","https://openalex.org/W2042805026","https://openalex.org/W2046019785","https://openalex.org/W2050397606","https://openalex.org/W2050903454","https://openalex.org/W2058024825","https://openalex.org/W2063720970","https://openalex.org/W2072652145","https://openalex.org/W2074330116","https://openalex.org/W2074885718","https://openalex.org/W2083327596","https://openalex.org/W2088852221","https://openalex.org/W2089399307","https://openalex.org/W2092246706","https://openalex.org/W2095923443","https://openalex.org/W2096595413","https://openalex.org/W2112234186","https://openalex.org/W2113038139","https://openalex.org/W2113762171","https://openalex.org/W2120083721","https://openalex.org/W2125439417","https://openalex.org/W2128115766","https://openalex.org/W2128718528","https://openalex.org/W2129973402","https://openalex.org/W2130697926","https://openalex.org/W2138721972","https://openalex.org/W2140695722","https://openalex.org/W2145348622","https://openalex.org/W2147962660","https://openalex.org/W2149178067","https://openalex.org/W2158880737","https://openalex.org/W2164044730","https://openalex.org/W2165476856","https://openalex.org/W2327060038","https://openalex.org/W4239482816"],"related_works":["https://openalex.org/W7095627320","https://openalex.org/W1933608698","https://openalex.org/W2149178067","https://openalex.org/W2041412815","https://openalex.org/W1865343003","https://openalex.org/W1982898602","https://openalex.org/W4416285860","https://openalex.org/W2057010805","https://openalex.org/W4399689220","https://openalex.org/W4411291467"],"abstract_inverted_index":{"The":[0,40],"inhibitory":[1],"neurotransmitter":[2],"GABA":[3,61,220],"is":[4,53,84,132,154,165,188],"synthesized":[5,219],"by":[6,75,95],"the":[7,34,43,66,108,149,176,203],"enzyme":[8],"glutamic":[9],"acid":[10],"decarboxylase":[11],"(GAD)":[12],"in":[13,16,19,93,117,128,135,139,146,155,159,186,191,211,229],"neurons":[14,94,187],"and":[15,29,48,58,69,82,90,99,111,115,124,127,138,172,198,224],"pancreatic":[17],"\u03b2-cells":[18,212],"islets":[20,126,230],"of":[21,36,42,60,71,113,120,151,181,217,227,231],"Langerhans":[22],"where":[23],"it":[24],"functions":[25],"as":[26],"a":[27,97,100],"paracrine":[28],"autocrine":[30],"signaling":[31],"molecule":[32],"regulating":[33],"function":[35],"islet":[37,192],"endocrine":[38],"cells.":[39,130],"localization":[41],"two":[44],"non-allelic":[45],"isoforms":[46],"GAD65":[47,72,116,131,164],"GAD67":[49,79,114,153,182],"to":[50,86,169,183,208,213],"vesicular":[51,87,173,209],"membranes":[52,137,171],"important":[54],"for":[55,62,167,179,221],"rapid":[56,215],"delivery":[57],"accumulation":[59,216],"regulated":[63,222],"secretion.":[64],"While":[65],"membrane":[67,88,109],"anchoring":[68],"trafficking":[70],"are":[73],"mediated":[74],"intrinsic":[76],"hydrophobic":[77],"modifications,":[78],"remains":[80],"hydrophilic,":[81],"yet":[83],"targeted":[85],"pathways":[89],"synaptic":[91,184],"clusters":[92],"both":[96],"GAD65-dependent":[98],"distinct":[101,142],"GAD65-independent":[102,177],"mechanism.":[103],"Herein":[104],"we":[105],"have":[106],"investigated":[107],"association":[110],"targeting":[112,168,180],"monolayer":[118],"cultures":[119],"primary":[121],"rat,":[122],"human,":[123],"mouse":[125],"insulinoma":[129],"primarily":[133,157],"detected":[134],"Golgi":[136,170],"peripheral":[140],"vesicles":[141,145,185],"from":[143],"insulin":[144],"\u03b2-cells.":[147,193],"In":[148],"absence":[150],"GAD65,":[152],"contrast":[156],"cytosolic":[158],"\u03b2-cells;":[160],"its":[161],"co-expression":[162],"with":[163],"necessary":[166],"compartments.":[174],"Thus,":[175],"mechanism":[178],"not":[189,202],"functional":[190],"Therefore,":[194],"only":[195],"GAD65:GAD65":[196],"homodimers":[197],"GAD67:GAD65":[199],"heterodimers,":[200],"but":[201],"GAD67:GAD67":[204],"homodimer":[205],"gain":[206],"access":[207],"compartments":[210],"facilitate":[214],"newly":[218],"secretion":[223],"fine":[225],"tuning":[226],"GABA-signaling":[228],"Langerhans.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
