{"id":"https://openalex.org/W2016254262","doi":"https://doi.org/10.1007/s00726-006-0320-3","title":"Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson\u2019s disease","display_name":"Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson\u2019s disease","publication_year":2006,"publication_date":"2006-05-20","ids":{"openalex":"https://openalex.org/W2016254262","doi":"https://doi.org/10.1007/s00726-006-0320-3","mag":"2016254262","pmid":"https://pubmed.ncbi.nlm.nih.gov/16715415"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-006-0320-3","doi":"https://doi.org/10.1007/s00726-006-0320-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-006-0320-3","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086329377","display_name":"Paola Bonsi","orcid":"https://orcid.org/0000-0001-5940-9028","observed_orcids":["https://orcid.org/0000-0001-5940-9028"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Bonsi","raw_affiliation_strings":["Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia - C.E.R.C., European Brain Research Institute, Rome, Italy","Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia - C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020864104","display_name":"Dario Cuomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Cuomo","raw_affiliation_strings":["Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003176709","display_name":"Barbara Picconi","orcid":"https://orcid.org/0000-0001-6020-1021","observed_orcids":["https://orcid.org/0000-0001-6020-1021"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B. Picconi","raw_affiliation_strings":["Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079527374","display_name":"Giuseppe Sciamanna","orcid":"https://orcid.org/0000-0002-0070-1638","observed_orcids":["https://orcid.org/0000-0002-0070-1638"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Sciamanna","raw_affiliation_strings":["Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090327610","display_name":"Anne Tscherter","orcid":"https://orcid.org/0000-0002-6972-482X","observed_orcids":["https://orcid.org/0000-0002-6972-482X"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Tscherter","raw_affiliation_strings":["Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087278542","display_name":"Massimo Tolu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Tolu","raw_affiliation_strings":["Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021429755","display_name":"Giorgio Bernardi","orcid":"https://orcid.org/0000-0001-8630-6657","observed_orcids":["https://orcid.org/0000-0001-8630-6657","https://orcid.org/0000-0002-2837-2442"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Bernardi","raw_affiliation_strings":["Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088823694","display_name":"Paolo Calabresi","orcid":"https://orcid.org/0000-0003-0326-5509","observed_orcids":["https://orcid.org/0000-0003-0326-5509"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Calabresi","raw_affiliation_strings":["Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Universit\u00e0 di Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022210828","display_name":"Antonio Pisani","orcid":"https://orcid.org/0000-0002-8432-594X","observed_orcids":["https://orcid.org/0000-0002-8432-594X"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Pisani","raw_affiliation_strings":["Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Neurologica, Dipartimento di Neuroscienze, Universit\u00e0 Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Laboratorio di Neurofisiologia, I.R.C.C.S. Fondazione Santa Lucia \u2013 C.E.R.C., European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264","https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":3.3457,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.91484268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"2","first_page":"189","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cholinergic-interneurons","display_name":"cholinergic interneurons","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mglur2","display_name":"mGluR2","score":0.8730000257492065},{"id":"https://openalex.org/keywords/group-i-mglurs","display_name":"group I mGluRs","score":0.7519999742507935},{"id":"https://openalex.org/keywords/group-ii-mglurs","display_name":"group II mGluRs","score":0.8519999980926514},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.8650000095367432},{"id":"https://openalex.org/keywords/n-type-calcium-channels","display_name":"N-type calcium channels","score":0.7950000166893005},{"id":"https://openalex.org/keywords/antiparkinsonian-drugs","display_name":"antiparkinsonian drugs","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.727191150188446},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.6155485510826111},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5622732043266296},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.496886283159256},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.49513664841651917},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4753701090812683},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.45687878131866455},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4235732853412628},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.4131208062171936},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3684523105621338},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3618108034133911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3105957806110382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29789960384368896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1696120798587799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16262492537498474},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09005016088485718}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00726-006-0320-3","doi":"https://doi.org/10.1007/s00726-006-0320-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-006-0320-3","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},{"id":"pmid:16715415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16715415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino acids","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/88292","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/88292","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W10954641","https://openalex.org/W1563615702","https://openalex.org/W1707125763","https://openalex.org/W1716703308","https://openalex.org/W1844692487","https://openalex.org/W1972908219","https://openalex.org/W1974240711","https://openalex.org/W1974366641","https://openalex.org/W1978171643","https://openalex.org/W1978986475","https://openalex.org/W1980704135","https://openalex.org/W1984393517","https://openalex.org/W1988665122","https://openalex.org/W1991272199","https://openalex.org/W1996805443","https://openalex.org/W2001232602","https://openalex.org/W2002574600","https://openalex.org/W2003472138","https://openalex.org/W2007870025","https://openalex.org/W2014439239","https://openalex.org/W2017505808","https://openalex.org/W2018998508","https://openalex.org/W2022426651","https://openalex.org/W2024911651","https://openalex.org/W2025964028","https://openalex.org/W2033160727","https://openalex.org/W2033345218","https://openalex.org/W2033963948","https://openalex.org/W2035375625","https://openalex.org/W2036575624","https://openalex.org/W2041271928","https://openalex.org/W2046592350","https://openalex.org/W2048791034","https://openalex.org/W2048941040","https://openalex.org/W2058623213","https://openalex.org/W2059820056","https://openalex.org/W2061934797","https://openalex.org/W2063205768","https://openalex.org/W2071203240","https://openalex.org/W2074402500","https://openalex.org/W2076464393","https://openalex.org/W2078877182","https://openalex.org/W2082689582","https://openalex.org/W2083832493","https://openalex.org/W2084069325","https://openalex.org/W2088947382","https://openalex.org/W2089271111","https://openalex.org/W2089721916","https://openalex.org/W2091070579","https://openalex.org/W2108547360","https://openalex.org/W2112972456","https://openalex.org/W2113171895","https://openalex.org/W2147252238","https://openalex.org/W2151143710","https://openalex.org/W2157450061","https://openalex.org/W2158956441","https://openalex.org/W2171601518","https://openalex.org/W2233543443","https://openalex.org/W2277185635","https://openalex.org/W2410277366","https://openalex.org/W4322703206"],"related_works":["https://openalex.org/W2178039548","https://openalex.org/W2359931691","https://openalex.org/W3049065873","https://openalex.org/W154169386","https://openalex.org/W4248431072","https://openalex.org/W2884144427","https://openalex.org/W2035149159","https://openalex.org/W2383678931","https://openalex.org/W1974898145","https://openalex.org/W2067317860"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}