{"id":"https://openalex.org/W2016246684","doi":"https://doi.org/10.1016/s0092-8674(04)00166-7","title":"Tumor Necrosis Factor","display_name":"Tumor Necrosis Factor","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2016246684","doi":"https://doi.org/10.1016/s0092-8674(04)00166-7","mag":"2016246684","pmid":"https://pubmed.ncbi.nlm.nih.gov/14980217"},"language":"en","primary_location":{"id":"doi:10.1016/s0092-8674(04)00166-7","doi":"https://doi.org/10.1016/s0092-8674(04)00166-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00166-7","pdf_url":"http://www.cell.com/article/S0092867404001667/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016246684"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867404001667/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052364035","display_name":"Eugene E. Varfolomeev","orcid":"https://orcid.org/0000-0002-2887-3730","observed_orcids":["https://orcid.org/0000-0002-2887-3730"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene E Varfolomeev","raw_affiliation_strings":["Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028133447","display_name":"Avi Ashkenazi","orcid":"https://orcid.org/0000-0002-6890-4589","observed_orcids":["https://orcid.org/0000-0002-6890-4589"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avi Ashkenazi","raw_affiliation_strings":["Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028133447"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":4.0831,"has_fulltext":false,"cited_by_count":509,"citation_normalized_percentile":{"value":0.96952181,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"116","issue":"4","first_page":"491","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.753000020980835},{"id":"https://openalex.org/keywords/ikk-nf-kappab-signaling","display_name":"IKK/NF-\u03baB signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/jnk-ap-1-signaling","display_name":"JNK/AP-1 signaling","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9431703090667725},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47880110144615173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3420863151550293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3278721570968628},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22692379355430603}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0092-8674(04)00166-7","doi":"https://doi.org/10.1016/s0092-8674(04)00166-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00166-7","pdf_url":"http://www.cell.com/article/S0092867404001667/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:14980217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14980217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0092-8674(04)00166-7","doi":"https://doi.org/10.1016/s0092-8674(04)00166-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(04)00166-7","pdf_url":"http://www.cell.com/article/S0092867404001667/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325124","display_name":"CYTED Ciencia y Tecnolog\u00eda para el Desarrollo","ror":"https://ror.org/03myqtf56"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016246684.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1492587973","https://openalex.org/W1499561015","https://openalex.org/W1967894078","https://openalex.org/W1968295892","https://openalex.org/W1976883744","https://openalex.org/W1983398917","https://openalex.org/W1990239056","https://openalex.org/W1990248374","https://openalex.org/W1993936200","https://openalex.org/W1994219871","https://openalex.org/W1996681941","https://openalex.org/W2000476522","https://openalex.org/W2009781189","https://openalex.org/W2023331434","https://openalex.org/W2023420554","https://openalex.org/W2035091743","https://openalex.org/W2035967893","https://openalex.org/W2038118195","https://openalex.org/W2057942179","https://openalex.org/W2064832070","https://openalex.org/W2072380594","https://openalex.org/W2076515532","https://openalex.org/W2080389159","https://openalex.org/W2087877138","https://openalex.org/W2091349259","https://openalex.org/W2094835614","https://openalex.org/W2097672870","https://openalex.org/W2098975407","https://openalex.org/W2114727688","https://openalex.org/W2138779676","https://openalex.org/W2146965545","https://openalex.org/W2468351845","https://openalex.org/W2470223656","https://openalex.org/W6649712139"],"related_works":["https://openalex.org/W135265483","https://openalex.org/W2065257477","https://openalex.org/W1986962873","https://openalex.org/W1966565183","https://openalex.org/W2133984207","https://openalex.org/W2101499471","https://openalex.org/W2244504533","https://openalex.org/W2097672870","https://openalex.org/W2063702713","https://openalex.org/W2033882650"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
