{"id":"https://openalex.org/W2016241657","doi":"https://doi.org/10.1074/jbc.274.30.21326","title":"Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase","display_name":"Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2016241657","doi":"https://doi.org/10.1074/jbc.274.30.21326","mag":"2016241657","pmid":"https://pubmed.ncbi.nlm.nih.gov/10409692"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.30.21326","doi":"https://doi.org/10.1074/jbc.274.30.21326","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.30.21326","pdf_url":"http://www.jbc.org/article/S0021925819725812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819725812/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022854559","display_name":"Aron B. Fisher","orcid":"https://orcid.org/0000-0003-2445-435X","observed_orcids":["https://orcid.org/0000-0003-2445-435X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aron B. Fisher","raw_affiliation_strings":["Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068, USA. abf@mail.med.upenn.edu","From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068, USA. abf@mail.med.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021560480","display_name":"Chandra Dodia","orcid":"https://orcid.org/0000-0002-8309-6575","observed_orcids":["https://orcid.org/0000-0002-8309-6575"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra Dodia","raw_affiliation_strings":["From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111919055","display_name":"Yefim Manevich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yefim Manevich","raw_affiliation_strings":["From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074257037","display_name":"Jinwen Chen","orcid":"https://orcid.org/0000-0002-8413-2187","observed_orcids":["https://orcid.org/0000-0002-8413-2187"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Wen Chen","raw_affiliation_strings":["From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054698138","display_name":"Sheldon I. Feinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheldon I. Feinstein","raw_affiliation_strings":["From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022854559"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.9265,"has_fulltext":true,"cited_by_count":299,"citation_normalized_percentile":{"value":0.94751857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"274","issue":"30","first_page":"21326","last_page":"21334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-cys-peroxiredoxin","display_name":"1-Cys peroxiredoxin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/phospholipid-hydroperoxides","display_name":"phospholipid hydroperoxides","score":0.996999979019165},{"id":"https://openalex.org/keywords/phosphatidylcholine-hydroperoxide","display_name":"phosphatidylcholine hydroperoxide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/ping-pong-mechanism","display_name":"ping-pong mechanism","score":0.996999979019165},{"id":"https://openalex.org/keywords/selenoenzymes","display_name":"selenoenzymes","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.859121561050415},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.715009868144989},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.6819526553153992},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6474658846855164},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.6200037002563477},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.6016051769256592},{"id":"https://openalex.org/C2781264002","wikidata":"https://www.wikidata.org/wiki/Q3724651","display_name":"Phospholipid-hydroperoxide glutathione peroxidase","level":5,"score":0.5982353687286377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5223385095596313},{"id":"https://openalex.org/C203580378","wikidata":"https://www.wikidata.org/wiki/Q18026462","display_name":"GPX3","level":5,"score":0.5137192010879517},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.45257750153541565},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3585524260997772},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1927851438522339},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.06514438986778259}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.30.21326","doi":"https://doi.org/10.1074/jbc.274.30.21326","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.30.21326","pdf_url":"http://www.jbc.org/article/S0021925819725812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10409692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10409692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.30.21326","doi":"https://doi.org/10.1074/jbc.274.30.21326","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.30.21326","pdf_url":"http://www.jbc.org/article/S0021925819725812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2939536134","display_name":"Cellular and molecular biology of lung surfactant","funder_award_id":"P01HL019737","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6677581136","display_name":"SCOR IN ACUTE LUNG INJURY","funder_award_id":"P50HL060290","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G781498313","display_name":null,"funder_award_id":"HL 19737.","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000189229","display_name":null,"funder_award_id":"HL19737","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016241657.pdf","grobid_xml":"https://content.openalex.org/works/W2016241657.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1506594192","https://openalex.org/W1567800226","https://openalex.org/W1953600943","https://openalex.org/W1966773551","https://openalex.org/W1967099953","https://openalex.org/W1983668291","https://openalex.org/W1984510490","https://openalex.org/W1992174071","https://openalex.org/W2004335062","https://openalex.org/W2008613157","https://openalex.org/W2040224411","https://openalex.org/W2042698393","https://openalex.org/W2043834820","https://openalex.org/W2061506033","https://openalex.org/W2066639890","https://openalex.org/W2074687883","https://openalex.org/W2083024240","https://openalex.org/W2083734035","https://openalex.org/W2092463196","https://openalex.org/W2094943100","https://openalex.org/W2141960134","https://openalex.org/W2153875468","https://openalex.org/W2168082981","https://openalex.org/W2213073484","https://openalex.org/W2267571706","https://openalex.org/W4247160664","https://openalex.org/W4292410652","https://openalex.org/W4300932895"],"related_works":["https://openalex.org/W65835826","https://openalex.org/W2325138581","https://openalex.org/W2066639890","https://openalex.org/W2061686638","https://openalex.org/W2366762427","https://openalex.org/W1987171188","https://openalex.org/W995921749","https://openalex.org/W4313478560","https://openalex.org/W2148207815","https://openalex.org/W2027712360"],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"phospholipid":[3,114,125,215],"hydroperoxides":[4,39,105],"as":[5,40,106,182],"substrates":[6],"for":[7,48],"non-selenium":[8],"GSH":[9,32,141,205],"peroxidase":[10,33,206],"(NSGPx),":[11],"an":[12,222],"enzyme":[13,138,219],"also":[14],"called":[15],"1-Cys":[16],"peroxiredoxin.":[17],"Recombinant":[18],"human":[19,27],"NSGPx":[20,192],"expressed":[21],"in":[22,184],"Escherichia":[23],"coli":[24],"from":[25,149,194],"a":[26,61,150,155,203,210],"cDNA":[28,145,196],"clone":[29],"(HA0683)":[30],"showed":[31,160],"activity":[34,109,118],"with":[35,54,60,101,113,124,133],"sn-2-linolenoyl-":[36],"or":[37,43],"sn-2-arachidonoyl-phosphatidylcholine":[38],"substrate;":[41],"NADPH":[42],"thioredoxin":[44],"could":[45],"not":[46,52,173,209],"substitute":[47],"GSH.":[49],"Activity":[50,123],"did":[51],"saturate":[53],"GSH,":[55,86],"and":[56,74,92,103,168,171,212],"kinetics":[57],"were":[58,68],"compatible":[59],"ping-pong":[62],"mechanism;":[63],"kinetic":[64],"constants":[65],"(mM(-1)":[66],"min(-1))":[67],"k(1)":[69],"=":[70,76],"1-3":[71],"x":[72,78],"10(5)":[73],"k(2)":[75],"4-11":[77],"10(4).":[79],"In":[80],"the":[81,175,195],"presence":[82],"of":[83,98,190,225],"0.36":[84],"mM":[85],"apparent":[87,93],"K(m)":[88],"was":[89,95,119,128],"120-130":[90],"microM":[91],"V(max)":[94],"1.5-1.6":[96],"micromol/min/mg":[97],"protein.":[99],"Assays":[100],"H(2)O(2)":[102],"organic":[104],"substrate":[107,127],"indicated":[108],"similar":[110],"to":[111,163],"that":[112,207],"hydroperoxides.":[115,216],"Maximal":[116],"enzymatic":[117],"at":[120],"pH":[121],"7-8.":[122],"hydroperoxide":[126],"inhibited":[129],"noncompetitively":[130],"by":[131],"mercaptosuccinate":[132],"K(i)":[134],"4":[135],"miroM.":[136],"The":[137,187],"had":[139],"no":[140],"S-transferase":[142],"activity.":[143],"Bovine":[144],"encoding":[146],"NSGPx,":[147],"isolated":[148],"lung":[151],"expression":[152],"library":[153],"using":[154],"polymerase":[156],"chain":[157],"reaction":[158],"probe,":[159],">95%":[161],"similarity":[162],"previously":[164],"published":[165],"human,":[166],"rat,":[167],"mouse":[169],"sequences":[170],"does":[172],"contain":[174],"TGA":[176],"stop":[177],"codon,":[178],"which":[179],"is":[180,197,208],"translated":[181],"selenocysteine":[183],"selenium-containing":[185],"peroxidases.":[186],"molecular":[188],"mass":[189],"bovine":[191],"deduced":[193],"25,047":[198],"Da.":[199],"These":[200],"results":[201],"identify":[202],"new":[204],"selenoenzyme":[211],"can":[213],"reduce":[214],"Thus,":[217],"this":[218],"may":[220],"be":[221],"important":[223],"component":[224],"cellular":[226],"antioxidant":[227],"defense":[228],"systems.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}