{"id":"https://openalex.org/W2016238544","doi":"https://doi.org/10.1186/s13075-015-0526-4","title":"Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response","display_name":"Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response","publication_year":2015,"publication_date":"2015-01-19","ids":{"openalex":"https://openalex.org/W2016238544","doi":"https://doi.org/10.1186/s13075-015-0526-4","mag":"2016238544","pmid":"https://pubmed.ncbi.nlm.nih.gov/25604867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4332922"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-015-0526-4","doi":"https://doi.org/10.1186/s13075-015-0526-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0526-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0526-4.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0526-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019159322","display_name":"Jun Kikuchi","orcid":"https://orcid.org/0000-0003-3231-8841","observed_orcids":["https://orcid.org/0000-0003-3231-8841"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Kikuchi","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. j_kiku_chi@yahoo.co.jp","Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. j_kiku_chi@yahoo.co.jp","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112132939","display_name":"Misato Hashizume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misato Hashizume","raw_affiliation_strings":["Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd 1-135 Komakado, Gotemba, Shizuoka, 412-8513, Japan. hashizumemst@chugai-pharm.co.jp","Product Research Department, Fuji-Gotemba Research Laboratories, Gotemba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd 1-135 Komakado, Gotemba, Shizuoka, 412-8513, Japan. hashizumemst@chugai-pharm.co.jp","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Product Research Department, Fuji-Gotemba Research Laboratories, Gotemba, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039165431","display_name":"Yuko Kaneko","orcid":"https://orcid.org/0000-0003-2646-5765","observed_orcids":["https://orcid.org/0000-0003-2646-5765"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Kaneko","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ykaneko@z6.keio.jp","Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ykaneko@z6.keio.jp","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040489632","display_name":"Keiko Yoshimoto","orcid":"https://orcid.org/0000-0002-6491-267X","observed_orcids":["https://orcid.org/0000-0002-6491-267X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Yoshimoto","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. keikoy@a8.keio.jp","Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. keikoy@a8.keio.jp","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007888732","display_name":"Naoshi Nishina","orcid":"https://orcid.org/0000-0002-1879-5230","observed_orcids":["https://orcid.org/0000-0002-1879-5230"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoshi Nishina","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. nnnmd11@hotmail.com","Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. nnnmd11@hotmail.com","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083314956","display_name":"Tsutomu Takeuchi","orcid":"https://orcid.org/0000-0003-1111-8218","observed_orcids":["https://orcid.org/0000-0003-1111-8218"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsutomu Takeuchi","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. tsutake@z5.keio.jp","Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. tsutake@z5.keio.jp","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083314956"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":8.9991,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.98518014,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd4-cd25-cd127low","display_name":"CD4+CD25+CD127low","score":0.9369999766349792},{"id":"https://openalex.org/keywords/il-6-receptor-inhibition","display_name":"IL-6 receptor inhibition","score":0.8980000019073486},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.8349999785423279},{"id":"https://openalex.org/keywords/disease-activity-remission","display_name":"disease activity remission","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.718999981880188},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6899999976158142},{"id":"https://openalex.org/keywords/peripheral-immune-cells","display_name":"peripheral immune cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8880577683448792},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.7707607746124268},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.7385547161102295},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6395527124404907},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.6103577613830566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6100022792816162},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5536994934082031},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.4810495674610138},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47484710812568665},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29706594347953796}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053699","descriptor_name":"Interleukin-7 Receptor alpha Subunit","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13075-015-0526-4","doi":"https://doi.org/10.1186/s13075-015-0526-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0526-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0526-4.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:25604867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25604867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4332922","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4332922/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"mag:2185865606","doi":null,"is_oa":false,"landing_page_url":"https://arthritis-research.biomedcentral.com/track/pdf/10.1186/s13075-015-0526-4?site=arthritis-research.biomedcentral.com","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/s13075-015-0526-4","doi":"https://doi.org/10.1186/s13075-015-0526-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-015-0526-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13075-015-0526-4.pdf","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016238544.pdf","grobid_xml":"https://content.openalex.org/works/W2016238544.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W46650105","https://openalex.org/W132722136","https://openalex.org/W1515725948","https://openalex.org/W1553772156","https://openalex.org/W1592680099","https://openalex.org/W1612533388","https://openalex.org/W1965827638","https://openalex.org/W1969021940","https://openalex.org/W1973683306","https://openalex.org/W1986543207","https://openalex.org/W1991026693","https://openalex.org/W2002076761","https://openalex.org/W2014081699","https://openalex.org/W2027342494","https://openalex.org/W2028862182","https://openalex.org/W2036010160","https://openalex.org/W2037259928","https://openalex.org/W2060912271","https://openalex.org/W2062006937","https://openalex.org/W2091404190","https://openalex.org/W2104669609","https://openalex.org/W2105487639","https://openalex.org/W2110826367","https://openalex.org/W2113633952","https://openalex.org/W2113702834","https://openalex.org/W2123249923","https://openalex.org/W2148009861","https://openalex.org/W2152348310","https://openalex.org/W2155779547","https://openalex.org/W2157130851","https://openalex.org/W2168822788","https://openalex.org/W2171057871","https://openalex.org/W2175632479","https://openalex.org/W2739730770","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2185865606","https://openalex.org/W2320571795","https://openalex.org/W7208202867","https://openalex.org/W7139299639","https://openalex.org/W7139792565","https://openalex.org/W2312291008","https://openalex.org/W2808578821","https://openalex.org/W2554970367","https://openalex.org/W2409487485","https://openalex.org/W2910676852"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tocilizumab":[1],"(TCZ),":[2],"an":[3],"anti-interleukin-6":[4],"receptor":[5],"antibody,":[6],"is":[7,31],"clinically":[8],"effective":[9],"against":[10],"rheumatoid":[11],"arthritis":[12],"(RA),":[13],"and":[14,42,63,91,114,156,169,197,201,215],"several":[15,99],"reports":[16],"have":[17],"indicated":[18],"how":[19],"TCZ":[20,35,83,146,164,265],"influences":[21],"a":[22],"number":[23],"of":[24,57,59,98,101,107,109,140,145,150,176,191,268,278],"mechanisms":[25],"underlying":[26],"RA":[27,69,78],"pathogenesis.":[28],"However,":[29],"it":[30],"still":[32],"unclear":[33],"whether":[34,43],"affects":[36],"inflammatory":[37],"cells":[38,62,103,154,160,181,227,249,271,280,283],"in":[39,66,138,225,234,247,252,272],"peripheral":[40,60,102],"blood":[41],"any":[44],"such":[45],"changes":[46],"are":[47],"associated":[48],"with":[49,68,71,77,104,163,231,274,286],"clinical":[50,64,287],"response.":[51,288],"We":[52],"evaluated":[53],"associations":[54],"between":[55,88],"proportions":[56,97,149,175,190,267],"subsets":[58,100],"immune":[61,270],"response":[65],"patients":[67,76,141,273],"treated":[70],"TCZ.":[72],"METHODS:":[73],"Thirty-nine":[74],"consecutive":[75],"who":[79],"started":[80],"to":[81,122],"receive":[82],"as":[84],"their":[85,105],"first":[86],"biologic":[87],"March":[89],"2010":[90],"April":[92],"2012":[93],"were":[94,117],"enrolled.":[95],"The":[96,148,189,243,276],"levels":[106],"expression":[108],"differentiation":[110],"markers,":[111],"activation":[112],"markers":[113],"costimulatory":[115],"molecules":[116],"measured":[118],"sequentially":[119],"from":[120],"baseline":[121],"week":[123,143],"52":[124,144,187],"by":[125],"flow":[126],"cytometry":[127],"analysis.":[128],"RESULTS:":[129],"Clinical":[130],"Disease":[131],"Activity":[132],"Index":[133],"(CDAI)":[134],"remission":[135,255],"was":[136,228,250],"achieved":[137],"53.8%":[139],"at":[142],"therapy.":[147],"CD4(+)CD25(+)CD127(low)":[151],"regulatory":[152],"T":[153,178],"(Treg)":[155],"HLA-DR(+)":[157],"activated":[158,199],"Treg":[159,226,248,279],"significantly":[161,204],"increased":[162],"therapy":[165],"(P":[166,206,257],"<":[167,171,207,210,213,217,258],"0.001":[168,214],"P":[170,209,212,216,240],"0.001,":[172,208,211,218],"respectively),":[173],"whereas":[174],"CD3(+)CD4(+)CXCR3(-)CCR6(+)CD161(+)":[177],"helper":[179],"17":[180],"did":[182],"not":[183],"change":[184,224,233],"over":[185],"the":[186,223,232,253],"weeks.":[188],"CD20(+)CD27(+)":[192],"memory":[193],"B":[194],"cells,":[195],"HLA-DR(+)CD14(+)":[196],"CD69(+)CD14(+)":[198],"monocytes,":[200],"CD16(+)CD14(+)":[202],"monocytes":[203],"decreased":[205],"respectively).":[219],"Among":[220],"them,":[221],"only":[222],"inversely":[229],"correlated":[230,284],"CDAI":[235,254],"score":[236],"(\u03c1":[237],"=":[238,241],"-0.40,":[239],"0.011).":[242],"most":[244],"dynamic":[245],"increase":[246],"observed":[251],"group":[256],"0.001).":[259],"CONCLUSION:":[260],"This":[261],"study":[262],"demonstrates":[263],"that":[264],"affected":[266],"circulating":[269],"RA.":[275],"proportion":[277],"among":[281],"CD4(+)":[282],"well":[285]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
