{"id":"https://openalex.org/W2016230098","doi":"https://doi.org/10.1371/journal.ppat.1001121","title":"Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner","display_name":"Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner","publication_year":2010,"publication_date":"2010-09-23","ids":{"openalex":"https://openalex.org/W2016230098","doi":"https://doi.org/10.1371/journal.ppat.1001121","mag":"2016230098","pmid":"https://pubmed.ncbi.nlm.nih.gov/20886108","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2944813"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1001121","doi":"https://doi.org/10.1371/journal.ppat.1001121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001121","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001121&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016230098"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001121&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029679802","display_name":"Asuka Nanbo","orcid":"https://orcid.org/0000-0001-8764-1350","observed_orcids":["https://orcid.org/0000-0001-8764-1350"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asuka Nanbo","raw_affiliation_strings":["Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066012827","display_name":"Masaki Imai","orcid":"https://orcid.org/0000-0001-6988-1975","observed_orcids":["https://orcid.org/0000-0001-6988-1975"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Imai","raw_affiliation_strings":["Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103503588","display_name":"Shinji Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Watanabe","raw_affiliation_strings":["ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030412761","display_name":"Takeshi Noda","orcid":"https://orcid.org/0000-0002-0658-4663","observed_orcids":["https://orcid.org/0000-0002-0658-4663"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Noda","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614592","display_name":"Kei Takahashi","orcid":"https://orcid.org/0000-0002-7925-6636","observed_orcids":["https://orcid.org/0000-0002-7925-6636"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Takahashi","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064426145","display_name":"Gabriele Neumann","orcid":"https://orcid.org/0000-0001-7054-1775","observed_orcids":["https://orcid.org/0000-0001-7054-1775"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriele Neumann","raw_affiliation_strings":["Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071340041","display_name":"Peter Halfmann","orcid":"https://orcid.org/0000-0002-1648-1625","observed_orcids":["https://orcid.org/0000-0002-1648-1625"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Halfmann","raw_affiliation_strings":["Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076363097","display_name":"Yoshihiro Kawaoka","orcid":"https://orcid.org/0000-0001-5061-8296","observed_orcids":["https://orcid.org/0000-0001-5061-8296"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Yoshihiro Kawaoka","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan","ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan","Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076363097"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210086780","https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":18.9821,"has_fulltext":true,"cited_by_count":449,"citation_normalized_percentile":{"value":0.9969881,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"6","issue":"9","first_page":"e1001121","last_page":"e1001121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebolavirus","display_name":"Ebolavirus","score":0.7910000085830688},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.7599999904632568},{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-glycoproteins","display_name":"viral glycoproteins","score":0.8299999833106995},{"id":"https://openalex.org/keywords/snx5","display_name":"SNX5","score":0.703000009059906},{"id":"https://openalex.org/keywords/macropinosomes","display_name":"macropinosomes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/caveolae-mediated-endocytosis","display_name":"caveolae-mediated endocytosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.75},{"id":"https://openalex.org/keywords/hemorrhagic-fever","display_name":"hemorrhagic fever","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.8704568147659302},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.83245849609375},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8268886804580688},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7676901817321777},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.7327889204025269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.693553626537323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5122891664505005},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5069835186004639},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.4455738365650177},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4453658163547516},{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.33349621295928955},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19758003950119019},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12101525068283081},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05694785714149475},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.05269476771354675},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090802","descriptor_name":"rab7 GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010873","descriptor_name":"Pinocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018116","descriptor_name":"Vesiculovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058305","descriptor_name":"Sorting Nexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058305","descriptor_name":"Sorting Nexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.ppat.1001121","doi":"https://doi.org/10.1371/journal.ppat.1001121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001121","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001121&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:20886108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20886108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2944813","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2944813/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007168515","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/50165","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/50165/PLoSP6-9_e1001121.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens","raw_type":"journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1033.8837","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1033.8837","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/50165/1/PLoSP6-9_e1001121.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.351.1561","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.1561","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d4/7a/PLoS_Pathog_2010_Sep_23_6(9)_e1001121.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9484873f2470438aad0e704f60e4cbe3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9484873f2470438aad0e704f60e4cbe3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 6, Iss 9, p e1001121 (2010)","raw_type":"article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/50165","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/50165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/141593","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Ebolavirus_Is_Internalized_into_Host_Cells_via_Macropinocytosis_in_a_Viral_Glycoprotein_Dependent_Manner/141593","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1001121","doi":"https://doi.org/10.1371/journal.ppat.1001121","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001121","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001121&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3195546111","display_name":"Molecular Basis for Ebola Virus Pathogenicity","funder_award_id":"R01AI055519","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6014488672","display_name":"Molecular Analyses and Interventions for Biodefense and Emerging Pathogens","funder_award_id":"U54AI057153","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016230098.pdf","grobid_xml":"https://content.openalex.org/works/W2016230098.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W183967228","https://openalex.org/W1509530066","https://openalex.org/W1575798288","https://openalex.org/W1885102277","https://openalex.org/W1964940884","https://openalex.org/W1970362643","https://openalex.org/W1972781853","https://openalex.org/W1974974166","https://openalex.org/W1982278641","https://openalex.org/W1988568170","https://openalex.org/W1988654342","https://openalex.org/W1992292664","https://openalex.org/W1993657150","https://openalex.org/W1995045410","https://openalex.org/W1996688457","https://openalex.org/W1997740378","https://openalex.org/W1999542797","https://openalex.org/W2003408366","https://openalex.org/W2007764474","https://openalex.org/W2012873813","https://openalex.org/W2013274873","https://openalex.org/W2013346825","https://openalex.org/W2021972288","https://openalex.org/W2022339063","https://openalex.org/W2024316397","https://openalex.org/W2025750305","https://openalex.org/W2026283030","https://openalex.org/W2028807809","https://openalex.org/W2029241563","https://openalex.org/W2032154790","https://openalex.org/W2038266165","https://openalex.org/W2051245442","https://openalex.org/W2055977452","https://openalex.org/W2057513374","https://openalex.org/W2065179139","https://openalex.org/W2065365365","https://openalex.org/W2066383202","https://openalex.org/W2067927396","https://openalex.org/W2069813642","https://openalex.org/W2075273454","https://openalex.org/W2078079771","https://openalex.org/W2078530446","https://openalex.org/W2080374377","https://openalex.org/W2080927554","https://openalex.org/W2081883645","https://openalex.org/W2082046491","https://openalex.org/W2086155380","https://openalex.org/W2087268191","https://openalex.org/W2087591542","https://openalex.org/W2089144568","https://openalex.org/W2089417835","https://openalex.org/W2093226717","https://openalex.org/W2095606194","https://openalex.org/W2095751049","https://openalex.org/W2097134015","https://openalex.org/W2097231877","https://openalex.org/W2102537321","https://openalex.org/W2104603012","https://openalex.org/W2107614388","https://openalex.org/W2108100159","https://openalex.org/W2108609481","https://openalex.org/W2109958551","https://openalex.org/W2111695773","https://openalex.org/W2112957690","https://openalex.org/W2113092416","https://openalex.org/W2113132163","https://openalex.org/W2113717339","https://openalex.org/W2115271408","https://openalex.org/W2115993724","https://openalex.org/W2116301223","https://openalex.org/W2118364979","https://openalex.org/W2120342771","https://openalex.org/W2121472371","https://openalex.org/W2122496291","https://openalex.org/W2124727351","https://openalex.org/W2125203230","https://openalex.org/W2126261381","https://openalex.org/W2127488207","https://openalex.org/W2128782078","https://openalex.org/W2128963410","https://openalex.org/W2135722581","https://openalex.org/W2136272810","https://openalex.org/W2138623102","https://openalex.org/W2138929242","https://openalex.org/W2139436990","https://openalex.org/W2139556812","https://openalex.org/W2145137218","https://openalex.org/W2149707874","https://openalex.org/W2152185625","https://openalex.org/W2152624614","https://openalex.org/W2154349549","https://openalex.org/W2156897762","https://openalex.org/W2160315282","https://openalex.org/W2163083344","https://openalex.org/W2167299010","https://openalex.org/W2167806590","https://openalex.org/W2167944112","https://openalex.org/W2171864254","https://openalex.org/W2172260616","https://openalex.org/W2226284032","https://openalex.org/W2394842998","https://openalex.org/W2396100249","https://openalex.org/W3193270327","https://openalex.org/W4238726741"],"related_works":["https://openalex.org/W2103795849","https://openalex.org/W2043674872","https://openalex.org/W1996037007","https://openalex.org/W2012873813","https://openalex.org/W2943407260","https://openalex.org/W2131848809","https://openalex.org/W4244086072","https://openalex.org/W2177312905"],"abstract_inverted_index":{"Ebolavirus":[0,71,83,94,103,112,145,178,201,222,232],"(EBOV)":[1],"is":[2,202],"an":[3],"enveloped,":[4],"single-stranded,":[5],"negative-sense":[6],"RNA":[7],"virus":[8,175],"that":[9,45,53,116,127,200],"causes":[10],"severe":[11],"hemorrhagic":[12],"fever":[13],"with":[14,78,130,156,183],"mortality":[15],"rates":[16],"of":[17,61,90,102,108,121,137,144,150,221,229],"up":[18],"to":[19],"90%":[20],"in":[21,35,95,169,209,226],"humans":[22],"and":[23,84,114,160,166,185,188,223],"nonhuman":[24],"primates.":[25],"Previous":[26],"studies":[27,77],"suggest":[28,199],"roles":[29],"for":[30,231],"clathrin-":[31,55,122],"or":[32,56,123],"caveolae-mediated":[33,57,124],"endocytosis":[34],"EBOV":[36,62],"entry;":[37],"however,":[38],"ebolavirus":[39],"virions":[40,146],"are":[41,46],"long,":[42],"filamentous":[43],"particles":[44,86,113],"larger":[47],"than":[48],"the":[49,100,142,148,177,219,227],"plasma":[50,157],"membrane":[51,158],"invaginations":[52],"characterize":[54],"endocytosis.":[58],"The":[59],"mechanism":[60,101],"entry":[63],"remains,":[64],"therefore,":[65],"poorly":[66],"understood.":[67],"To":[68],"better":[69],"understand":[70],"entry,":[72],"we":[73],"carried":[74],"out":[75],"internalization":[76,104,118,143,187],"fluorescently":[79,110],"labeled,":[80],"biologically":[81],"contained":[82],"Ebolavirus-like":[85],"(Ebola":[87],"VLPs),":[88],"both":[89],"which":[91],"resemble":[92],"authentic":[93],"their":[96,117],"morphology.":[97],"We":[98],"examined":[99],"by":[105,192,206],"real-time":[106],"analysis":[107],"these":[109],"labeled":[111],"found":[115],"was":[119,154,161],"independent":[120],"endocytosis,":[125],"but":[126],"they":[128],"co-localized":[129,182],"sorting":[131],"nexin":[132],"(SNX)":[133],"5,":[134],"a":[135,151,210],"marker":[136],"macropinocytosis-specific":[138,152],"endosomes":[139],"(macropinosomes).":[140],"Moreover,":[141],"accelerated":[147],"uptake":[149],"cargo,":[153],"associated":[155],"ruffling,":[159],"dependent":[162],"on":[163],"cellular":[164],"GTPases":[165],"kinases":[167],"involved":[168],"macropinocytosis.":[170],"A":[171],"pseudotyped":[172],"vesicular":[173],"stomatitis":[174],"possessing":[176],"glycoprotein":[179],"(GP)":[180],"also":[181],"SNX5":[184],"its":[186],"infectivity":[189],"were":[190],"affected":[191],"macropinocytosis":[193,208],"inhibitors.":[194],"Taken":[195],"together,":[196],"our":[197],"data":[198],"internalized":[203],"into":[204,218],"cells":[205],"stimulating":[207],"GP-dependent":[211],"manner.":[212],"These":[213],"findings":[214],"provide":[215],"new":[216],"insights":[217],"lifecycle":[220],"may":[224],"aid":[225],"development":[228],"therapeutics":[230],"infection.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":33},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}