{"id":"https://openalex.org/W2016228336","doi":"https://doi.org/10.1002/gcc.2870020207","title":"Cytogenetics of non\u2010small cell lung cancer: Analysis of consistent non\u2010random abnormalities","display_name":"Cytogenetics of non\u2010small cell lung cancer: Analysis of consistent non\u2010random abnormalities","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2016228336","doi":"https://doi.org/10.1002/gcc.2870020207","mag":"2016228336","pmid":"https://pubmed.ncbi.nlm.nih.gov/2177644"},"language":"en","primary_location":{"id":"doi:10.1002/gcc.2870020207","doi":"https://doi.org/10.1002/gcc.2870020207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870020207","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024805455","display_name":"Robyn E. Lukeis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robyn Lukeis","raw_affiliation_strings":["Cytogenetics Department, St. Vincent's Hospital, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytogenetics Department, St. Vincent's Hospital, Melbourne, Australia","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040119940","display_name":"Louis B. Irving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157122","display_name":"Heidelberg Repatriation Hospital","ror":"https://ror.org/04dhg0348","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210157122","https://openalex.org/I4210163497"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Louis Irving","raw_affiliation_strings":["Department of Thoracic Medicine, Repatriation Hospital, Heidelberg, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Medicine, Repatriation Hospital, Heidelberg, Australia","institution_ids":["https://openalex.org/I4210157122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034432682","display_name":"Margaret Garson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Margaret Garson","raw_affiliation_strings":["Cytogenetics Department, St. Vincent's Hospital, Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytogenetics Department, St. Vincent's Hospital, Melbourne","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111883833","display_name":"Suzanne Hasthorpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Suzanne Hasthorpe","raw_affiliation_strings":["Cell Biology Unit, Peter MacCallum Cancer Institute, Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Unit, Peter MacCallum Cancer Institute, Melbourne","institution_ids":["https://openalex.org/I2800555584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111883833"],"corresponding_institution_ids":["https://openalex.org/I2800555584"],"apc_list":{"value":4810,"currency":"USD","value_usd":4810},"apc_paid":null,"fwci":7.8083,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98093941,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"2","first_page":"116","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.30149999260902405,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.1054999977350235,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/karyotypic-abnormalities","display_name":"karyotype abnormalities","score":0.8569999933242798},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chromosome-9p-loss","display_name":"chromosome 9p loss","score":0.6639999747276306},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.8009999990463257},{"id":"https://openalex.org/keywords/non-reciprocal-translocation","display_name":"non-reciprocal translocation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/chromosomal-deletion","display_name":"chromosomal deletion","score":0.5139999985694885},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8360000252723694},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/large-cell-carcinoma","display_name":"large cell carcinoma","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.8084732294082642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.776664137840271},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7281600832939148},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.6980708241462708},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.6265518069267273},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.6173627972602844},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5173575282096863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46616441011428833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44858479499816895},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44643720984458923},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35307782888412476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16750267148017883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0897856056690216}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gcc.2870020207","doi":"https://doi.org/10.1002/gcc.2870020207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870020207","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},{"id":"pmid:2177644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2177644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, chromosomes & cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W54298579","https://openalex.org/W274791679","https://openalex.org/W1602193081","https://openalex.org/W1768947806","https://openalex.org/W1942253855","https://openalex.org/W1975549289","https://openalex.org/W1976685817","https://openalex.org/W1979040485","https://openalex.org/W1980049624","https://openalex.org/W2001962665","https://openalex.org/W2005175893","https://openalex.org/W2011146989","https://openalex.org/W2011623472","https://openalex.org/W2024698452","https://openalex.org/W2030480699","https://openalex.org/W2038905538","https://openalex.org/W2056947516","https://openalex.org/W2071741589","https://openalex.org/W2079216916","https://openalex.org/W2081837269","https://openalex.org/W2085226130","https://openalex.org/W2088245458","https://openalex.org/W2088706525","https://openalex.org/W2095148741","https://openalex.org/W2096501569","https://openalex.org/W2137584840","https://openalex.org/W2164171045","https://openalex.org/W2166208988","https://openalex.org/W2239709517","https://openalex.org/W2315734235","https://openalex.org/W2316252570","https://openalex.org/W2339359539","https://openalex.org/W2405992225","https://openalex.org/W2414011356","https://openalex.org/W2806677308"],"related_works":["https://openalex.org/W2083048426","https://openalex.org/W2402736353","https://openalex.org/W1973482241","https://openalex.org/W2136698114","https://openalex.org/W2051225020","https://openalex.org/W2417493447","https://openalex.org/W1485587458","https://openalex.org/W2152416636","https://openalex.org/W2034615780","https://openalex.org/W2051629662"],"abstract_inverted_index":{"Cytogenetic":[0],"analysis":[1],"of":[2,40,66,72,147],"ten":[3],"primary":[4,133],"non-small":[5],"cell":[6,16,21],"lung":[7],"carcinomas":[8,23],"(NSCLC),":[9],"including":[10],"five":[11],"adenocarcinomas":[12],"(ADC),":[13],"three":[14],"squamous":[15],"(SQC),":[17],"and":[18,47,54,62,129],"two":[19],"large":[20],"(LCC)":[22],"has":[24,138],"been":[25,140],"carried":[26],"out":[27],"in":[28,36,63,92,136],"an":[29],"attempt":[30],"to":[31,83,96,110,114,118,123],"determine":[32],"karyotype":[33],"changes":[34],"involved":[35,104],"the":[37,69,93],"early":[38],"stage":[39],"disease.":[41],"The":[42],"tumors":[43],"were":[44,60,91,102],"all":[45],"aneuploid":[46],"exhibited":[48],"complex":[49],"karyotypes":[50],"with":[51],"multiple":[52],"structural":[53,58],"numerical":[55],"abnormalities.":[56],"Clonal":[57],"rearrangements":[59],"identified":[61,141],"particular":[64],"loss":[65,80,146],"material":[67,148],"from":[68,149],"short":[70],"arm":[71],"chromosome":[73,88,99],"9":[74],"had":[75],"a":[76,132,152],"90%":[77],"incidence.":[78],"This":[79],"was":[81],"due":[82],"non-reciprocal":[84],"translocation,":[85],"deletion,":[86],"or":[87],"loss.":[89],"Breakpoints":[90],"region":[94],"9q13":[95],"p22.":[97],"Other":[98],"regions":[100],"that":[101],"non-randomly":[103],"are":[105],"as":[106,151],"follows:":[107],"I":[108],"cen":[109],"p13,":[111],"3p,":[112],"5q11":[113],"q13,":[115],"6p,":[116],"6q15":[117],"q27,":[119],"7p,":[120],"8p,":[121],"11q12":[122],"q23,":[124],"13p,":[125],"14p,":[126],"15p,":[127],"17p,":[128],"19p.":[130],"While":[131],"cytogenetic":[134],"change":[135],"NSCLC":[137],"not":[139],"conclusively,":[142],"our":[143],"findings":[144],"implicate":[145],"9p":[150],"potentially":[153],"important":[154],"event.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
