{"id":"https://openalex.org/W2016226316","doi":"https://doi.org/10.1186/s12885-015-1101-8","title":"Prediction of resistance to chemotherapy in ovarian cancer: a systematic review","display_name":"Prediction of resistance to chemotherapy in ovarian cancer: a systematic review","publication_year":2015,"publication_date":"2015-03-10","ids":{"openalex":"https://openalex.org/W2016226316","doi":"https://doi.org/10.1186/s12885-015-1101-8","mag":"2016226316","pmid":"https://pubmed.ncbi.nlm.nih.gov/25886033","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4371880"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-015-1101-8","doi":"https://doi.org/10.1186/s12885-015-1101-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1101-8","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1101-8","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1101-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013227537","display_name":"Katherine Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Katherine L Lloyd","raw_affiliation_strings":["MOAC DTC, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. K.Lloyd.1@warwick.ac.uk","MOAC DTC, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOAC DTC, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. K.Lloyd.1@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"MOAC DTC, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014188852","display_name":"Ian A. Cree","orcid":"https://orcid.org/0000-0001-5007-9456","observed_orcids":["https://orcid.org/0000-0001-5007-9456"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian A Cree","raw_affiliation_strings":["Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. I.A.Cree@warwick.ac.uk","Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. I.A.Cree@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086506904","display_name":"Richard S. Savage","orcid":"https://orcid.org/0000-0001-6025-1571","observed_orcids":["https://orcid.org/0000-0001-6025-1571"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard S Savage","raw_affiliation_strings":["Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. R.S.Savage@warwick.ac.uk","Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. R.S.Savage@warwick.ac.uk","Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. R.S.Savage@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. R.S.Savage@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013227537"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":1887,"currency":"EUR","value_usd":2035},"fwci":0.9385,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.72476415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy-response-prediction","display_name":"chemotherapy response prediction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8410000205039978},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9470000267028809},{"id":"https://openalex.org/keywords/treatment-stratification","display_name":"treatment stratification","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cox-proportional-hazards-model","display_name":"Cox proportional hazards model","score":0.703000009059906},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"hierarchical clustering","score":0.953000009059906},{"id":"https://openalex.org/keywords/patient-heterogeneity","display_name":"patient heterogeneity","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7060990333557129},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.684768557548523},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6662843227386475},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6631022691726685},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6212694048881531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5400444269180298},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37769487500190735},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36256688833236694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12347817420959473}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12885-015-1101-8","doi":"https://doi.org/10.1186/s12885-015-1101-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1101-8","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1101-8","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3334313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4371880","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25886033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25886033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4371880","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4371880/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:wrap.warwick.ac.uk:67521","doi":null,"is_oa":false,"landing_page_url":"http://wrap.warwick.ac.uk/67521/7/WRAP-prediction-resistance-chemotherapy-cancer-Lloyd-2017.pdf","pdf_url":"http://wrap.warwick.ac.uk/67521/7/WRAP-prediction-resistance-chemotherapy-cancer-Lloyd-2017.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.797.4642","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.797.4642","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/89/6f/12885_2015_Article_1101.PMC4371880.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/s12885-015-1101-8","doi":"https://doi.org/10.1186/s12885-015-1101-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1101-8","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-015-1101-8","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[{"id":"https://openalex.org/G1384939613","display_name":null,"funder_award_id":"EP/F500378","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3971908992","display_name":"LSI Doctoral Training Centres - Molecular organisation and assembly in cells (MOAC) doctoral training centre","funder_award_id":"EP/F500378/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4567785811","display_name":null,"funder_award_id":"1229056","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016226316.pdf","grobid_xml":"https://content.openalex.org/works/W2016226316.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W76995436","https://openalex.org/W187500563","https://openalex.org/W369902469","https://openalex.org/W1509500531","https://openalex.org/W1525054294","https://openalex.org/W1536513511","https://openalex.org/W1546749513","https://openalex.org/W1694119819","https://openalex.org/W1727426604","https://openalex.org/W1793477442","https://openalex.org/W1954448220","https://openalex.org/W1965766554","https://openalex.org/W1967781801","https://openalex.org/W1969016700","https://openalex.org/W1969298821","https://openalex.org/W1979816698","https://openalex.org/W1984214747","https://openalex.org/W1985299015","https://openalex.org/W1993086521","https://openalex.org/W1993865220","https://openalex.org/W1995242599","https://openalex.org/W1995911541","https://openalex.org/W1996989652","https://openalex.org/W1999555459","https://openalex.org/W1999659639","https://openalex.org/W2009514656","https://openalex.org/W2009978277","https://openalex.org/W2012695246","https://openalex.org/W2018044006","https://openalex.org/W2029660804","https://openalex.org/W2030328721","https://openalex.org/W2031674672","https://openalex.org/W2034269086","https://openalex.org/W2049306821","https://openalex.org/W2056475199","https://openalex.org/W2062289724","https://openalex.org/W2070640051","https://openalex.org/W2071646545","https://openalex.org/W2078344435","https://openalex.org/W2081287664","https://openalex.org/W2081635337","https://openalex.org/W2082346958","https://openalex.org/W2085422244","https://openalex.org/W2086430651","https://openalex.org/W2095264870","https://openalex.org/W2097777938","https://openalex.org/W2098421558","https://openalex.org/W2099201986","https://openalex.org/W2099826569","https://openalex.org/W2104989537","https://openalex.org/W2106980005","https://openalex.org/W2107638293","https://openalex.org/W2107919129","https://openalex.org/W2109449896","https://openalex.org/W2110065044","https://openalex.org/W2111803165","https://openalex.org/W2116704045","https://openalex.org/W2117058881","https://openalex.org/W2121677423","https://openalex.org/W2123664981","https://openalex.org/W2124913959","https://openalex.org/W2128160790","https://openalex.org/W2128215249","https://openalex.org/W2129907662","https://openalex.org/W2130748155","https://openalex.org/W2133932878","https://openalex.org/W2134785517","https://openalex.org/W2135377323","https://openalex.org/W2137525633","https://openalex.org/W2142240220","https://openalex.org/W2147539392","https://openalex.org/W2147754310","https://openalex.org/W2148408457","https://openalex.org/W2149391237","https://openalex.org/W2150508723","https://openalex.org/W2153682492","https://openalex.org/W2156691266","https://openalex.org/W2157630129","https://openalex.org/W2158006786","https://openalex.org/W2158289485","https://openalex.org/W2162115413","https://openalex.org/W2170454539","https://openalex.org/W2310034942","https://openalex.org/W2478075821","https://openalex.org/W2491532353","https://openalex.org/W2498143926","https://openalex.org/W2505281917"],"related_works":["https://openalex.org/W7096911063","https://openalex.org/W2536264152","https://openalex.org/W2748131858","https://openalex.org/W2095264870","https://openalex.org/W2218769729","https://openalex.org/W2124913959","https://openalex.org/W2243386871","https://openalex.org/W2972563948","https://openalex.org/W2040904607","https://openalex.org/W2790970832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patient":[1,141],"response":[2,56,167],"to":[3,17,25,59,146,151,168,181],"chemotherapy":[4,26,60,152,169],"for":[5,53,197],"ovarian":[6,69],"cancer":[7],"is":[8],"extremely":[9],"heterogeneous":[10,148],"and":[11,27,76,81,107,115,188],"there":[12],"are":[13],"currently":[14],"no":[15],"tools":[16],"aid":[18,189],"the":[19,41,78,99,124,190,193],"prediction":[20],"of":[21,65,88,164,192],"sensitivity":[22],"or":[23,57,92],"resistance":[24,58],"allow":[28],"treatment":[29,44,153,196],"stratification.":[30],"Such":[31],"a":[32,46,177],"tool":[33],"could":[34,184],"greatly":[35],"improve":[36],"patient":[37,166],"survival":[38],"by":[39,113,123,136,155],"identifying":[40],"most":[42,100,194],"appropriate":[43],"on":[45],"patient-specific":[47],"basis.":[48],"METHODS:":[49],"PubMed":[50],"was":[51],"searched":[52],"studies":[54,73,89,117,126],"predicting":[55,165],"using":[61],"gene":[62,120,161],"expression":[63],"measurements":[64],"human":[66],"tissue":[67],"in":[68],"cancer.":[70],"RESULTS:":[71],"42":[72],"were":[74,84,111,127,143],"identified":[75,122,135],"both":[77],"data":[79],"collection":[80],"modelling":[82],"methods":[83],"compared.":[85],"The":[86,119],"majority":[87],"utilised":[90],"fresh-frozen":[91],"formalin-fixed":[93],"paraffin-embedded":[94],"tissue.":[95],"Modelling":[96],"techniques":[97],"varied,":[98],"popular":[101],"being":[102,134],"Cox":[103],"proportional":[104],"hazards":[105],"regression":[106],"hierarchical":[108],"clustering":[109],"which":[110],"used":[112],"17":[114],"11":[116],"respectively.":[118],"signatures":[121],"various":[125],"not":[128,171],"consistent,":[129],"with":[130,149],"very":[131],"few":[132],"genes":[133],"more":[137],"than":[138],"two":[139],"studies.":[140],"cohorts":[142],"often":[144],"noted":[145],"be":[147,185],"respect":[150],"undergone":[154],"patients.":[156,198],"CONCLUSIONS:":[157],"A":[158],"clinically":[159],"applicable":[160],"signature":[162],"capable":[163],"has":[170],"yet":[172],"been":[173],"identified.":[174],"Research":[175],"into":[176],"predictive,":[178],"as":[179],"opposed":[180],"prognostic,":[182],"model":[183],"highly":[186],"beneficial":[187],"identification":[191],"suitable":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}