{"id":"https://openalex.org/W2016215595","doi":"https://doi.org/10.1016/s0960-894x(01)80363-2","title":"Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5\u03b1-reductases","display_name":"Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5\u03b1-reductases","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2016215595","doi":"https://doi.org/10.1016/s0960-894x(01)80363-2","mag":"2016215595"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(01)80363-2","doi":"https://doi.org/10.1016/s0960-894x(01)80363-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(01)80363-2","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033537928","display_name":"Andrew David Abell","orcid":"https://orcid.org/0000-0002-0604-2629","observed_orcids":["https://orcid.org/0000-0002-0604-2629"]},"institutions":[{"id":"https://openalex.org/I185492890","display_name":"University of Canterbury","ror":"https://ror.org/03y7q9t39","country_code":"NZ","type":"education","lineage":["https://openalex.org/I185492890"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Andrew D. Abell","raw_affiliation_strings":["Department of Chemistry, University of Canterburgy, Christchruch, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Canterburgy, Christchruch, New Zealand","institution_ids":["https://openalex.org/I185492890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047823547","display_name":"Karl F. Erhard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl F. Erhard","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060540021","display_name":"Hwa-Kwo Yen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hwa-Kwo Yen","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023131186","display_name":"Dennis S. Yamashita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis S. Yamashita","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010791135","display_name":"Martin Albertsen Brandt","orcid":"https://orcid.org/0000-0002-6668-608X","observed_orcids":["https://orcid.org/0000-0002-6668-608X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Brandt","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hadiza Mohammed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hadiza Mohammed","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002157510","display_name":"Mark A. Levy","orcid":"https://orcid.org/0000-0003-0515-6402","observed_orcids":["https://orcid.org/0000-0003-0515-6402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A. Levy","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108778306","display_name":"Dennis A. Holt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis A. Holt","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals P.O. Box 1539, King of Prussia, Pennsylvania 19406-0939 U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":1.7236,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81124678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"11","first_page":"1365","last_page":"1368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereoisomers","display_name":"stereoisomers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chiral-hplc-separation","display_name":"chiral HPLC separation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/5alpha-reductase","display_name":"5\u03b1-reductase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7580000162124634},{"id":"https://openalex.org/keywords/5alpha-reductase-inhibitors","display_name":"5-alpha reductase inhibitors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cis-trans-isomers","display_name":"cis-trans isomers","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8908646702766418},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.8494929671287537},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6080357432365417},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5872879028320312},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.556063175201416},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43898388743400574},{"id":"https://openalex.org/C16838498","wikidata":"https://www.wikidata.org/wiki/Q5101828","display_name":"Chiral column chromatography","level":3,"score":0.4213225543498993},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40158283710479736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3436862826347351},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08752280473709106}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0960-894x(01)80363-2","doi":"https://doi.org/10.1016/s0960-894x(01)80363-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(01)80363-2","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1885778179","https://openalex.org/W1968513119","https://openalex.org/W1968886375","https://openalex.org/W1974392957","https://openalex.org/W1980808116","https://openalex.org/W1997479221","https://openalex.org/W2011305346","https://openalex.org/W2023481449","https://openalex.org/W2033429556","https://openalex.org/W2037740608","https://openalex.org/W2043240231","https://openalex.org/W2063412547","https://openalex.org/W2065051917","https://openalex.org/W2070483549"],"related_works":["https://openalex.org/W2950849453","https://openalex.org/W2043240231","https://openalex.org/W2054204811","https://openalex.org/W2105863158","https://openalex.org/W2047589511","https://openalex.org/W1996055876","https://openalex.org/W1966043426","https://openalex.org/W2082475525","https://openalex.org/W2949472988","https://openalex.org/W2127020986"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}