{"id":"https://openalex.org/W2016208214","doi":"https://doi.org/10.1159/000054892","title":"Dexamethasone Blocking Effects on Mu- and Delta-Opioid-Induced Seizures Involves Kappa-Opioid Activity in the Rabbit","display_name":"Dexamethasone Blocking Effects on Mu- and Delta-Opioid-Induced Seizures Involves Kappa-Opioid Activity in the Rabbit","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2016208214","doi":"https://doi.org/10.1159/000054892","mag":"2016208214","pmid":"https://pubmed.ncbi.nlm.nih.gov/11287802"},"language":"en","primary_location":{"id":"doi:10.1159/000054892","doi":"https://doi.org/10.1159/000054892","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000054892","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110089748","display_name":"Amalia Di Giannuario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amalia Di Giannuario","raw_affiliation_strings":["Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy. dig@iss.it","Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy. dig@iss.it","institution_ids":["https://openalex.org/I27897274"]},{"raw_affiliation_string":"Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053697476","display_name":"Stefano Pieretti","orcid":"https://orcid.org/0000-0001-5926-6194","observed_orcids":["https://orcid.org/0000-0001-5926-6194"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Pieretti","raw_affiliation_strings":["Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071135664","display_name":"Stefano Sagratella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Sagratella","raw_affiliation_strings":["Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103409909","display_name":"Alberto Loizzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Loizzo","raw_affiliation_strings":["Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Farmacologia, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27897274"],"apc_list":null,"apc_paid":null,"fwci":0.211,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.38542783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"3","first_page":"213","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/limbic-seizures","display_name":"limbic seizures","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hippocampal-seizures","display_name":"hippocampal seizures","score":0.8539999723434448},{"id":"https://openalex.org/keywords/damgo","display_name":"DAMGO","score":0.6940000057220459},{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/deltorphin-ii","display_name":"deltorphin II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nor-binaltorphimine","display_name":"nor-binaltorphimine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2776401185","wikidata":"https://www.wikidata.org/wiki/Q5204254","display_name":"DAMGO","level":5,"score":0.7964049577713013},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7110614776611328},{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.6215610504150391},{"id":"https://openalex.org/C184389661","wikidata":"https://www.wikidata.org/wiki/Q14897645","display_name":"\u03ba-opioid receptor","level":4,"score":0.6195881366729736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5709248185157776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5431933999061584},{"id":"https://openalex.org/C2777953665","wikidata":"https://www.wikidata.org/wiki/Q3743642","display_name":"Naltrindole","level":5,"score":0.5423446893692017},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.5174615979194641},{"id":"https://openalex.org/C14397066","wikidata":"https://www.wikidata.org/wiki/Q14911924","display_name":"\u03bc-opioid receptor","level":4,"score":0.499619722366333},{"id":"https://openalex.org/C141087196","wikidata":"https://www.wikidata.org/wiki/Q18030283","display_name":"\u03b4-opioid receptor","level":4,"score":0.4915080964565277},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4586941599845886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4427877962589264},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.42629849910736084},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.41444724798202515},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4100307822227478},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4073902666568756},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3702107071876526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2953333258628845}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020875","descriptor_name":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000054892","doi":"https://doi.org/10.1159/000054892","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000054892","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},{"id":"pmid:11287802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11287802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1593533288","https://openalex.org/W1904331358","https://openalex.org/W1953292148","https://openalex.org/W1964542686","https://openalex.org/W1990061387","https://openalex.org/W1992259420","https://openalex.org/W1992386379","https://openalex.org/W1994534741","https://openalex.org/W2002789477","https://openalex.org/W2005555425","https://openalex.org/W2005644491","https://openalex.org/W2008213128","https://openalex.org/W2019183259","https://openalex.org/W2019844519","https://openalex.org/W2024566047","https://openalex.org/W2029146004","https://openalex.org/W2030046198","https://openalex.org/W2030288420","https://openalex.org/W2035797844","https://openalex.org/W2036037610","https://openalex.org/W2041910569","https://openalex.org/W2044981665","https://openalex.org/W2053141298","https://openalex.org/W2055419187","https://openalex.org/W2057838369","https://openalex.org/W2062500236","https://openalex.org/W2067366123","https://openalex.org/W2068879074","https://openalex.org/W2070551672","https://openalex.org/W2075321336","https://openalex.org/W2075381062","https://openalex.org/W2079735814","https://openalex.org/W2082139480","https://openalex.org/W2082764732","https://openalex.org/W2085467730","https://openalex.org/W2089395194","https://openalex.org/W2112525570","https://openalex.org/W2140373598","https://openalex.org/W2156154823","https://openalex.org/W2161213045","https://openalex.org/W2170549926","https://openalex.org/W2170666484","https://openalex.org/W2259886213","https://openalex.org/W2277211833","https://openalex.org/W2406164919"],"related_works":["https://openalex.org/W2277211833","https://openalex.org/W2030046198","https://openalex.org/W2058890933","https://openalex.org/W1861741799","https://openalex.org/W2151700529","https://openalex.org/W2080734954","https://openalex.org/W2003270663","https://openalex.org/W2270026187","https://openalex.org/W2749303956","https://openalex.org/W1999721002"],"abstract_inverted_index":{"Previous":[0],"data":[1,20,105],"indicate":[2],"that":[3,27,107],"intracerebroventricular":[4],"administration":[5],"of":[6],"agonists":[7],"for":[8],"mu-":[9,29,113],"and":[10,30,36,44,52,64,76,114],"delta-opioid":[11,31],"receptors":[12],"induces":[13],"limbic":[14],"seizures":[15,66],"in":[16,23,46,71],"rats,":[17],"but":[18],"no":[19],"are":[21],"reported":[22],"rabbits.":[24],"We":[25],"found":[26],"the":[28,100],"peptides":[32],"[D-Ala(2)-N,Me-Phe(4)-Gly(5)-ol]enkephalin":[33],"(DAMGO),":[34],"beta-endorphin":[35],"deltorphin":[37,62],"II,":[38],"induced":[39,79],"EEG":[40],"non-convulsive":[41],"hippocampal":[42,47],"seizures,":[43],"changes":[45,70],"background":[48,72],"EEG,":[49,73],"physical":[50,74],"parameters":[51,75],"overt":[53,77],"behaviour":[54,78],"after":[55],"central":[56],"administration.":[57],"Dexamethasone":[58,83],"pre-treatment":[59,91],"prevented":[60],"DAMGO-,":[61],"II-":[63],"beta-endorphin-induced":[65],"as":[67,69],"well":[68],"by":[80,90,99],"mu-opioid":[81],"agonists.":[82],"antagonism":[84],"on":[85],"opioid":[86,110],"action":[87],"was":[88],"blocked":[89],"with":[92],"a":[93,117],"protein":[94,118],"synthesis":[95,119],"inhibitor,":[96],"cycloheximide":[97],"or":[98],"kappa-opioid":[101,122],"antagonist":[102],"nor-binaltorphimine.":[103],"Our":[104],"suggest":[106],"dexamethasone":[108],"influences":[109],"actions":[111],"at":[112],"delta-receptors":[115],"via":[116],"mechanism":[120],"involving":[121],"receptors.":[123]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
