{"id":"https://openalex.org/W2016203527","doi":"https://doi.org/10.1016/0091-6749(90)90194-9","title":"Relationship of different serum levels of theophylline on methacholine sensitivity","display_name":"Relationship of different serum levels of theophylline on methacholine sensitivity","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2016203527","doi":"https://doi.org/10.1016/0091-6749(90)90194-9","mag":"2016203527","pmid":"https://pubmed.ncbi.nlm.nih.gov/2182696"},"language":"en","primary_location":{"id":"doi:10.1016/0091-6749(90)90194-9","doi":"https://doi.org/10.1016/0091-6749(90)90194-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(90)90194-9","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111507173","display_name":"David G. Tinkelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David G. Tinkelman","raw_affiliation_strings":["Atlanta Allergy and Immunology Research Foundation, GA 30328","From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","Riker Laboratories Inc., St. Paul, Minn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Allergy and Immunology Research Foundation, GA 30328","institution_ids":[]},{"raw_affiliation_string":"From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","institution_ids":[]},{"raw_affiliation_string":"Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","institution_ids":[]},{"raw_affiliation_string":"Riker Laboratories Inc., St. Paul, Minn","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084131714","display_name":"Bikramjit S. Garcha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bikramjit S. Garcha","raw_affiliation_strings":["From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","Riker Laboratories Inc., St. Paul, Minn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","institution_ids":[]},{"raw_affiliation_string":"Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","institution_ids":[]},{"raw_affiliation_string":"Riker Laboratories Inc., St. Paul, Minn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110026102","display_name":"Cheryl N. Lutz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cheryl N. Lutz","raw_affiliation_strings":["From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","Riker Laboratories Inc., St. Paul, Minn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Immunopharmacology, Southampton Gen-eral Hospital, Southampton, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"Atlanta Allergy Clinic, 6667 Vernon Woods Drive, Atlanta, GA 30328","institution_ids":[]},{"raw_affiliation_string":"Dept. of Immunopharma-cology, Level D, Center Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, England","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"From the Atlanta Allergy and Immunology Research Foundation, Atlanta, Ga","institution_ids":[]},{"raw_affiliation_string":"Riker Laboratories Inc., St. Paul, Minn","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801388914"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":3.1787,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.91636928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"4","first_page":"750","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-theophylline-levels","display_name":"serum theophylline concentration","score":0.8600000143051147},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9950000047683716},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bronchodilator-effect","display_name":"bronchodilator effect","score":0.7319999933242798},{"id":"https://openalex.org/keywords/asthma-treatment","display_name":"asthma treatment","score":0.47699999809265137},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.5600000023841858},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8612114787101746},{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.8117386102676392},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.7988929748535156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7498714923858643},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7452518939971924},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7272988557815552},{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.7061104774475098},{"id":"https://openalex.org/C2776238763","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Bronchial hyperresponsiveness","level":4,"score":0.6290974617004395},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.627798318862915},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5576624870300293},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42810872197151184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3324102759361267},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.13227877020835876},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.08766582608222961},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008688","descriptor_name":"Methacholine Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0091-6749(90)90194-9","doi":"https://doi.org/10.1016/0091-6749(90)90194-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0091-6749(90)90194-9","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:2182696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2182696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1493135402","https://openalex.org/W1547396258","https://openalex.org/W1966374898","https://openalex.org/W2000094398","https://openalex.org/W2027387346","https://openalex.org/W2027831840","https://openalex.org/W2047163318","https://openalex.org/W2056824209","https://openalex.org/W2104626092","https://openalex.org/W2141824460","https://openalex.org/W2150379145","https://openalex.org/W2164828180","https://openalex.org/W2270655388","https://openalex.org/W2795740701","https://openalex.org/W2798054415","https://openalex.org/W3026430795","https://openalex.org/W4244034741","https://openalex.org/W4300135172"],"related_works":["https://openalex.org/W2017402423","https://openalex.org/W2118078720","https://openalex.org/W2141824460","https://openalex.org/W2411096507","https://openalex.org/W2408659369","https://openalex.org/W2405697878","https://openalex.org/W2056095406","https://openalex.org/W1973305223","https://openalex.org/W2193194865","https://openalex.org/W2003070392"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}