{"id":"https://openalex.org/W2016196138","doi":"https://doi.org/10.2500/aap2007.28.3043","title":"FoxP3-expressing T regulatory cells in atopic dermatitis lesions","display_name":"FoxP3-expressing T regulatory cells in atopic dermatitis lesions","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2016196138","doi":"https://doi.org/10.2500/aap2007.28.3043","mag":"2016196138","pmid":"https://pubmed.ncbi.nlm.nih.gov/18034969"},"language":"en","primary_location":{"id":"doi:10.2500/aap2007.28.3043","doi":"https://doi.org/10.2500/aap2007.28.3043","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap2007.28.3043","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016196138"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035693926","display_name":"Marzia Caproni","orcid":"https://orcid.org/0000-0002-7471-3471","observed_orcids":["https://orcid.org/0000-0002-7471-3471"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzia Caproni","raw_affiliation_strings":["From the Departments of Dermatological Sciences,","Department of Dermatological Sciences, University of Florence, Florence, Italy -"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatological Sciences,","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatological Sciences, University of Florence, Florence, Italy -","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033205792","display_name":"Emiliano Antiga","orcid":"https://orcid.org/0000-0001-7787-4433","observed_orcids":["https://orcid.org/0000-0001-7787-4433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emiliano Antiga","raw_affiliation_strings":["From the Departments of Dermatological Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatological Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076379186","display_name":"Daniele Torchia","orcid":"https://orcid.org/0000-0002-3030-5222","observed_orcids":["https://orcid.org/0000-0002-3030-5222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniele Torchia","raw_affiliation_strings":["From the Departments of Dermatological Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatological Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019267824","display_name":"Walter Volpi","orcid":"https://orcid.org/0000-0003-2264-5785","observed_orcids":["https://orcid.org/0000-0003-2264-5785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Volpi","raw_affiliation_strings":["From the Departments of Dermatological Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatological Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000592600","display_name":"Emanuela Barletta","orcid":"https://orcid.org/0000-0001-7493-1498","observed_orcids":["https://orcid.org/0000-0001-7493-1498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emanuela Barletta","raw_affiliation_strings":["Experimental Pathology and Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology and Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055254416","display_name":"Gianni Gitti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianni Gitti","raw_affiliation_strings":["Surgical Oto-Neuro-Ophthalmological Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oto-Neuro-Ophthalmological Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026533942","display_name":"Enrico de' Campora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico De Campora","raw_affiliation_strings":["Surgical Oto-Neuro-Ophthalmological Sciences, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oto-Neuro-Ophthalmological Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032614403","display_name":"Paolo Fabbri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Fabbri","raw_affiliation_strings":["From the Departments of Dermatological Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Dermatological Sciences,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0483,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84770155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"5","first_page":"525","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.8529999852180481},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dermis","display_name":"dermis","score":0.6050000190734863},{"id":"https://openalex.org/keywords/perivascular-inflammatory-infiltrate","display_name":"perivascular infiltrates","score":0.7680000066757202},{"id":"https://openalex.org/keywords/dermal-epidermal-junction","display_name":"basement membrane zone","score":0.8579999804496765},{"id":"https://openalex.org/keywords/treg-dysfunction","display_name":"Treg dysfunction","score":0.49900001287460327},{"id":"https://openalex.org/keywords/skin-immunology","display_name":"skin immunology","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7697358727455139},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.763923168182373},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.70558100938797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7012341618537903},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.633547306060791},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6161566376686096},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3237249255180359},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2804749011993408},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.13124877214431763},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10323220491409302}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2500/aap2007.28.3043","doi":"https://doi.org/10.2500/aap2007.28.3043","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap2007.28.3043","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},{"id":"pmid:18034969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18034969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and asthma proceedings","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/250522","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/250522","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095764400","https://openalex.org/W1887030808","https://openalex.org/W2011883392","https://openalex.org/W7046025867","https://openalex.org/W2274855482","https://openalex.org/W2080802467","https://openalex.org/W2401022462","https://openalex.org/W1998203976","https://openalex.org/W2127672658","https://openalex.org/W4399230107"],"abstract_inverted_index":{"Recently,":[0],"studies":[1],"were":[2,57,94,135],"conducted":[3],"to":[4,27],"evaluate":[5],"the":[6,15,82,97,108,112,138,155,178],"impact":[7],"of":[8,17,23,87,167,180],"T":[9,31,169],"regulatory":[10],"(T":[11],"regs)":[12],"cells":[13,79,93,105,134,152],"in":[14,35,43,96,137,177],"pathophysiology":[16,179],"atopic":[18],"dermatitis":[19],"(AD).":[20],"The":[21,55,157],"aim":[22],"this":[24],"study":[25],"was":[26,75],"investigate":[28],"whether":[29],"natural":[30,168],"regs":[32,170],"are":[33],"present":[34,160],"AD":[36,50,101,181],"skin":[37,41,120,146],"lesions.":[38,182],"We":[39],"performed":[40,76],"biopsies":[42],"12":[44],"adult":[45],"patients":[46],"affected":[47],"by":[48],"moderate-to-severe":[49],"and":[51,63,73,84,91,99,103,111,114,125,141,144,159],"4":[52],"healthy":[53,119,145],"volunteers.":[54],"specimens":[56,121,147],"stained":[58],"immunohistochemically":[59],"with":[60],"anti-human":[61],"CD25":[62,72,124],"forkhead/winged":[64],"helix":[65],"transcription":[66],"factor":[67],"(FoxP3).":[68],"Double":[69,128],"immunostaining":[70,129],"for":[71],"FoxP3":[74,126],"also.":[77],"CD25+":[78,132,150],"strongly":[80],"infiltrated":[81,107],"perivascular":[83,98],"papillar":[85],"dermis":[86],"all":[88],"lesional":[89],"specimens,":[90],"FoxP3+":[92,133,151],"distributed":[95,136],"interstitial":[100],"dermis,":[102,143],"some":[104],"also":[106],"dermoepidermal":[109],"junction":[110],"basal":[113],"suprabasal":[115],"epidermal":[116],"layers.":[117],"All":[118],"showed":[122,130],"weak":[123],"stainings.":[127],"that":[131,163],"perivascular,":[139],"interstitial,":[140],"periadnexal":[142],"featured":[148],"few":[149],"scattered":[153],"throughout":[154],"dermis.":[156],"past":[158],"data":[161],"show":[162],"an":[164],"impaired":[165],"function":[166],"may":[171],"not":[172],"play":[173],"a":[174],"primary":[175],"role":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}