{"id":"https://openalex.org/W2016195709","doi":"https://doi.org/10.1038/nrcardio.2014.84","title":"Lipid lowering with PCSK9 inhibitors","display_name":"Lipid lowering with PCSK9 inhibitors","publication_year":2014,"publication_date":"2014-06-24","ids":{"openalex":"https://openalex.org/W2016195709","doi":"https://doi.org/10.1038/nrcardio.2014.84","mag":"2016195709","pmid":"https://pubmed.ncbi.nlm.nih.gov/24958078"},"language":"en","primary_location":{"id":"doi:10.1038/nrcardio.2014.84","doi":"https://doi.org/10.1038/nrcardio.2014.84","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrcardio.2014.84","pdf_url":null,"source":{"id":"https://openalex.org/S62674001","display_name":"Nature Reviews Cardiology","issn_l":"1759-5002","issn":["1759-5002","1759-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cardiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2016195709"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002910643","display_name":"Razvan Tudor Dadu","orcid":"https://orcid.org/0000-0001-6211-2487","observed_orcids":["https://orcid.org/0000-0001-6211-2487"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razvan T. Dadu","raw_affiliation_strings":["Sections of Cardiovascular Research and Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, MS A601, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Cardiovascular Research and Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, MS A601, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052604218","display_name":"Christie Mitchell Ballantyne","orcid":"https://orcid.org/0000-0002-6432-1730","observed_orcids":["https://orcid.org/0000-0002-6432-1730"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christie M. Ballantyne","raw_affiliation_strings":["Sections of Cardiovascular Research and Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, MS A601, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Cardiovascular Research and Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, MS A601, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052604218"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":6.0092,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.98277212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"10","first_page":"563","last_page":"575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/pcsk9","display_name":"PCSK9","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9049999713897705},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7670000195503235},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ldl-receptor-degradation","display_name":"LDL receptor degradation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.6039999723434448},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9359418749809265},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.7248691320419312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4038742780685425},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3449828624725342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3439890146255493},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.199682354927063},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.08323550224304199}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrcardio.2014.84","doi":"https://doi.org/10.1038/nrcardio.2014.84","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrcardio.2014.84","pdf_url":null,"source":{"id":"https://openalex.org/S62674001","display_name":"Nature Reviews Cardiology","issn_l":"1759-5002","issn":["1759-5002","1759-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cardiology","raw_type":"journal-article"},{"id":"pmid:24958078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24958078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W121888607","https://openalex.org/W161816689","https://openalex.org/W162053157","https://openalex.org/W166112863","https://openalex.org/W1504928698","https://openalex.org/W1528479054","https://openalex.org/W1546258268","https://openalex.org/W1546371417","https://openalex.org/W1607804102","https://openalex.org/W1899603104","https://openalex.org/W1923289550","https://openalex.org/W1964279010","https://openalex.org/W1965991218","https://openalex.org/W1970761589","https://openalex.org/W1976691226","https://openalex.org/W1978218523","https://openalex.org/W1986712359","https://openalex.org/W1987486422","https://openalex.org/W1988630960","https://openalex.org/W1989730880","https://openalex.org/W2001314633","https://openalex.org/W2003905161","https://openalex.org/W2011488276","https://openalex.org/W2012468719","https://openalex.org/W2019071303","https://openalex.org/W2019703802","https://openalex.org/W2020043339","https://openalex.org/W2022091279","https://openalex.org/W2024110748","https://openalex.org/W2027027250","https://openalex.org/W2027196973","https://openalex.org/W2028682402","https://openalex.org/W2036171802","https://openalex.org/W2040612932","https://openalex.org/W2042583787","https://openalex.org/W2046054972","https://openalex.org/W2049721223","https://openalex.org/W2050183947","https://openalex.org/W2050775226","https://openalex.org/W2054299101","https://openalex.org/W2054610237","https://openalex.org/W2055571770","https://openalex.org/W2055989853","https://openalex.org/W2059881177","https://openalex.org/W2067539811","https://openalex.org/W2069993714","https://openalex.org/W2071154679","https://openalex.org/W2078669364","https://openalex.org/W2085692308","https://openalex.org/W2086767312","https://openalex.org/W2088358411","https://openalex.org/W2088525830","https://openalex.org/W2089751391","https://openalex.org/W2096075279","https://openalex.org/W2096493016","https://openalex.org/W2102467926","https://openalex.org/W2103108681","https://openalex.org/W2103487568","https://openalex.org/W2103518970","https://openalex.org/W2103647780","https://openalex.org/W2104654286","https://openalex.org/W2105962383","https://openalex.org/W2106285889","https://openalex.org/W2108493094","https://openalex.org/W2108956796","https://openalex.org/W2110083155","https://openalex.org/W2110171695","https://openalex.org/W2117011155","https://openalex.org/W2118152092","https://openalex.org/W2119708151","https://openalex.org/W2120597207","https://openalex.org/W2122864632","https://openalex.org/W2126229169","https://openalex.org/W2127445212","https://openalex.org/W2128030263","https://openalex.org/W2130626257","https://openalex.org/W2131607570","https://openalex.org/W2136034547","https://openalex.org/W2138544596","https://openalex.org/W2138934576","https://openalex.org/W2139575534","https://openalex.org/W2140622082","https://openalex.org/W2141191772","https://openalex.org/W2142621342","https://openalex.org/W2146010644","https://openalex.org/W2148577580","https://openalex.org/W2154836846","https://openalex.org/W2155259933","https://openalex.org/W2157541343","https://openalex.org/W2158901329","https://openalex.org/W2159449551","https://openalex.org/W2163488353","https://openalex.org/W2165924268","https://openalex.org/W2167440359","https://openalex.org/W2170420840","https://openalex.org/W2247997571","https://openalex.org/W2327835991","https://openalex.org/W2407105331","https://openalex.org/W2423809522","https://openalex.org/W2520591007","https://openalex.org/W2604889046","https://openalex.org/W2620282028","https://openalex.org/W4210329910","https://openalex.org/W4230647879","https://openalex.org/W4236673002","https://openalex.org/W4238361227","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2340257704","https://openalex.org/W1985807832","https://openalex.org/W635875665","https://openalex.org/W2141398757","https://openalex.org/W2765203099","https://openalex.org/W7221126119","https://openalex.org/W2193234196","https://openalex.org/W1988630960","https://openalex.org/W2252288490","https://openalex.org/W2070070200"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":52},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}