{"id":"https://openalex.org/W2016195086","doi":"https://doi.org/10.1016/0167-4838(93)90012-g","title":"Chemical modification of octopine dehydrogenase by thiol-specific reagents: evidence for the presence of an essential cysteine at the catalytic site","display_name":"Chemical modification of octopine dehydrogenase by thiol-specific reagents: evidence for the presence of an essential cysteine at the catalytic site","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2016195086","doi":"https://doi.org/10.1016/0167-4838(93)90012-g","mag":"2016195086","pmid":"https://pubmed.ncbi.nlm.nih.gov/8399387"},"language":"en","primary_location":{"id":"doi:10.1016/0167-4838(93)90012-g","doi":"https://doi.org/10.1016/0167-4838(93)90012-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(93)90012-g","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102173993","display_name":"Saifuddin Sheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saifuddin Sheikh","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology, Kanpur","Dept. of Chemistry, Indian Inst, of Technology, Kanpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology, Kanpur","institution_ids":["https://openalex.org/I94234084"]},{"raw_affiliation_string":"Dept. of Chemistry, Indian Inst, of Technology, Kanpur","institution_ids":["https://openalex.org/I94234084"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111973373","display_name":"Sarvagya S. Katiyar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sarvagya S. Katiyar","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology, Kanpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology, Kanpur, India","institution_ids":["https://openalex.org/I94234084"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111973373"],"corresponding_institution_ids":["https://openalex.org/I94234084"],"apc_list":null,"apc_paid":null,"fwci":0.5435,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60500291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1202","issue":"2","first_page":"251","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.11289999634027481,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octopine-dehydrogenase","display_name":"octopine dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dtnb","display_name":"DTNB","score":0.8220000267028809},{"id":"https://openalex.org/keywords/n-ethylmaleimide","display_name":"N-ethylmaleimide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.6990000009536743},{"id":"https://openalex.org/keywords/coenzyme-binding-domain","display_name":"coenzyme-binding domain","score":0.628000020980835},{"id":"https://openalex.org/keywords/ph-dependent-inactivation","display_name":"pH-dependent inactivation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/reversible-inactivation","display_name":"reversible inactivation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/cyanolysis","display_name":"cyanolysis","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2777426643","wikidata":"https://www.wikidata.org/wiki/Q17915090","display_name":"DTNB","level":4,"score":0.8756544589996338},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.7940008640289307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7003344893455505},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.6331278681755066},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5859702229499817},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5420469045639038},{"id":"https://openalex.org/C2781253882","wikidata":"https://www.wikidata.org/wiki/Q770860","display_name":"Thio-","level":2,"score":0.4983997344970703},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.46728214621543884},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4648996889591217},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4236938953399658},{"id":"https://openalex.org/C2778741777","wikidata":"https://www.wikidata.org/wiki/Q2013941","display_name":"Octopine","level":5,"score":0.4144613742828369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4068067669868469},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1914215087890625},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.12708011269569397},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779656422","wikidata":"https://www.wikidata.org/wiki/Q2700446","display_name":"Agrobacterium","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013439","descriptor_name":"Sulfhydryl Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013439","descriptor_name":"Sulfhydryl Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0167-4838(93)90012-g","doi":"https://doi.org/10.1016/0167-4838(93)90012-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4838(93)90012-g","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},{"id":"pmid:8399387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8399387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1514866723","https://openalex.org/W1533205371","https://openalex.org/W1585431411","https://openalex.org/W1591911256","https://openalex.org/W1601189744","https://openalex.org/W1987537383","https://openalex.org/W1993762073","https://openalex.org/W2000635246","https://openalex.org/W2001714734","https://openalex.org/W2003336395","https://openalex.org/W2006370393","https://openalex.org/W2013856414","https://openalex.org/W2013944282","https://openalex.org/W2029488802","https://openalex.org/W2048067711","https://openalex.org/W2054267956","https://openalex.org/W2061097624","https://openalex.org/W2066529967","https://openalex.org/W2073067468","https://openalex.org/W2076717367","https://openalex.org/W2083236130","https://openalex.org/W2113528037","https://openalex.org/W2406333476","https://openalex.org/W2417743506"],"related_works":["https://openalex.org/W2406333476","https://openalex.org/W2168619709","https://openalex.org/W2140579243","https://openalex.org/W1517288770","https://openalex.org/W1531832028","https://openalex.org/W2049313701","https://openalex.org/W2062128692","https://openalex.org/W2001714734","https://openalex.org/W1987683597","https://openalex.org/W2414245105"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
