{"id":"https://openalex.org/W2016190567","doi":"https://doi.org/10.3109/0886022x.2012.744040","title":"Renal Cell Apoptosis and New Treatment Options in Sepsis-Induced Acute Kidney Injury","display_name":"Renal Cell Apoptosis and New Treatment Options in Sepsis-Induced Acute Kidney Injury","publication_year":2012,"publication_date":"2012-11-27","ids":{"openalex":"https://openalex.org/W2016190567","doi":"https://doi.org/10.3109/0886022x.2012.744040","mag":"2016190567","pmid":"https://pubmed.ncbi.nlm.nih.gov/23181751"},"language":"en","primary_location":{"id":"doi:10.3109/0886022x.2012.744040","doi":"https://doi.org/10.3109/0886022x.2012.744040","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0886022x.2012.744040","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.744040?needAccess=true&role=button","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.744040?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048920898","display_name":"Ay\u015fe \u015eeker Ko\u00e7kara","orcid":"https://orcid.org/0000-0001-7240-0124","observed_orcids":["https://orcid.org/0000-0001-7240-0124"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Ko\u00e7kara","raw_affiliation_strings":["Department of Nephrology, Cumhuriyet University Medical School, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Cumhuriyet University Medical School, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054200216","display_name":"Mansur Kayata\u015f","orcid":"https://orcid.org/0000-0003-3736-5911","observed_orcids":["https://orcid.org/0000-0003-3736-5911"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mansur Kayata\u015f","raw_affiliation_strings":["Department of Nephrology, Cumhuriyet University Medical School, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Cumhuriyet University Medical School, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054200216"],"corresponding_institution_ids":["https://openalex.org/I12700597"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":null,"fwci":0.6495,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.48525074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"35","issue":"2","first_page":"291","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9800000190734863},{"id":"https://openalex.org/keywords/renal-tubular-apoptosis","display_name":"renal tubular apoptosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/caspase-inhibitors","display_name":"caspase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/low-tidal-volume-ventilation","display_name":"low tidal volume ventilation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hemofiltration","display_name":"hemofiltration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sepsis-pathophysiology","display_name":"sepsis pathophysiology","score":0.6800000071525574},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9280084371566772},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.783491849899292},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7656688094139099},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5182080864906311},{"id":"https://openalex.org/C2777350860","wikidata":"https://www.wikidata.org/wiki/Q2425407","display_name":"Acute tubular necrosis","level":3,"score":0.49860048294067383},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4770573675632477},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.4647120237350464},{"id":"https://openalex.org/C2778865887","wikidata":"https://www.wikidata.org/wiki/Q2720606","display_name":"Hemofiltration","level":3,"score":0.4432756304740906},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.41606661677360535},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41596072912216187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3478505313396454},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006440","descriptor_name":"Hemofiltration","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/0886022x.2012.744040","doi":"https://doi.org/10.3109/0886022x.2012.744040","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0886022x.2012.744040","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.744040?needAccess=true&role=button","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},{"id":"pmid:23181751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23181751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal failure","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/0886022x.2012.744040","doi":"https://doi.org/10.3109/0886022x.2012.744040","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0886022x.2012.744040","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.744040?needAccess=true&role=button","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016190567.pdf","grobid_xml":"https://content.openalex.org/works/W2016190567.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1745634660","https://openalex.org/W1967912613","https://openalex.org/W1977905350","https://openalex.org/W1981106016","https://openalex.org/W1984219766","https://openalex.org/W1994043844","https://openalex.org/W2005609146","https://openalex.org/W2009907240","https://openalex.org/W2029442240","https://openalex.org/W2040266344","https://openalex.org/W2043829148","https://openalex.org/W2053412247","https://openalex.org/W2060849820","https://openalex.org/W2061497413","https://openalex.org/W2061863655","https://openalex.org/W2068928880","https://openalex.org/W2070743921","https://openalex.org/W2074300019","https://openalex.org/W2074987560","https://openalex.org/W2078297328","https://openalex.org/W2083378659","https://openalex.org/W2088220499","https://openalex.org/W2093655079","https://openalex.org/W2097265990","https://openalex.org/W2097665403","https://openalex.org/W2107294278","https://openalex.org/W2115285670","https://openalex.org/W2117520303","https://openalex.org/W2145053281","https://openalex.org/W2156122996","https://openalex.org/W2273371313","https://openalex.org/W2330528279"],"related_works":["https://openalex.org/W2320604506","https://openalex.org/W2061863655","https://openalex.org/W2330528279","https://openalex.org/W2616909311","https://openalex.org/W2590725567","https://openalex.org/W2042297791","https://openalex.org/W2068928880","https://openalex.org/W1543853904","https://openalex.org/W2015213851","https://openalex.org/W2016101498"],"abstract_inverted_index":{"Sepsis":[0],"is":[1,17,44,58,78,132,185,213],"a":[2,186,191,224],"common":[3,133],"and":[4,26,64,72,167,195,235],"important":[5,22],"cause":[6],"of":[7,19,31,54,85,88,93,99,152,169,179,182,214,233,246],"mortality":[8,27,236],"in":[9,28,41,49,82,106,125,134,140,149,207],"critically":[10,135],"ill":[11,136],"patients.":[12],"Acute":[13],"kidney":[14],"injury":[15],"(AKI)":[16],"one":[18],"the":[20,29,38,83,86,150,164,176,202,208,228,243],"most":[21],"factors":[23],"determining":[24],"morbidity":[25,234],"prognosis":[30],"sepsis.":[32],"Recent":[33],"studies":[34],"have":[35,147,249],"indicated":[36],"that":[37,48,129,156,162,248],"pathogenetic":[39],"mechanism":[40],"septic":[42,100],"AKI":[43,56],"totally":[45],"different":[46],"from":[47,60,201],"non-septic":[50],"AKI.":[51],"Our":[52],"understanding":[53,84],"sepsis-associated":[55],"pathophysiology":[57],"shifting":[59],"renal":[61,89,94,141],"vasoconstriction,":[62],"ischemia,":[63,115],"acute":[65,73],"tubular":[66,74,95,142],"necrosis":[67],"to":[68,239],"heterogeneous":[69],"vasodilation,":[70],"hyperemia,":[71],"apoptosis.":[75],"Especially,":[76],"apoptosis":[77,96,139],"gradually":[79],"gaining":[80],"importance":[81],"development":[87],"injury.":[90],"The":[91],"frequency":[92],"on":[97,227],"biopsies":[98],"patients":[101],"has":[102,122,223],"been":[103,123,250],"pointed":[104],"out":[105],"recently":[107],"published":[108],"studies.":[109],"Apoptosis":[110],"can":[111],"be":[112,205,240],"triggered":[113],"by":[114],"exogen":[116],"toxins,":[117],"or":[118],"endogen":[119],"mediators.":[120],"It":[121],"shown":[124],"some":[126],"animal":[127],"models":[128],"hyperglycemia,":[130],"which":[131,184],"patients,":[137],"causes":[138],"cells.":[143],"New":[144],"treatment":[145,212],"options":[146],"emerged":[148],"light":[151],"recent":[153],"findings.":[154],"Ghrelin":[155],"inhibits":[157],"pro-inflammatory":[158],"cytokines,":[159],"caspase":[160],"inhibitors":[161],"block":[163],"apoptotic":[165],"pathway,":[166],"suppression":[168],"anti-inflammatory":[170,220],"reactions":[171],"are":[172,237],"under":[173],"study.":[174],"Among":[175],"existing":[177],"methods":[178,197],"treatment,":[180],"usage":[181],"arginine,":[183],"vasopressor":[187],"agent,":[188],"ventilation":[189],"with":[190],"low":[192],"tidal":[193],"volume,":[194],"hemofiltration":[196],"cleaning":[198],"toxic":[199],"mediators":[200],"circulation":[203],"should":[204],"considered":[206],"first":[209],"place.":[210],"Hyperglycemia":[211],"major":[215],"importance,":[216],"since,":[217],"besides":[218],"its":[219],"effect,":[221],"it":[222],"protective":[225],"role":[226],"kidney.":[229],"Regarding":[230],"pathogenesis,":[231],"rates":[232],"aimed":[238],"reduced":[241],"through":[242],"new":[244],"agents":[245],"therapy":[247],"studied":[251],"on.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
