{"id":"https://openalex.org/W2016189298","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","title":"Noncontact versus contact imaging: An atomic force microscopic study on hepatic endothelial cellsin vitro","display_name":"Noncontact versus contact imaging: An atomic force microscopic study on hepatic endothelial cellsin vitro","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2016189298","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","mag":"2016189298"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039985144","display_name":"Filip Braet","orcid":"https://orcid.org/0000-0002-5222-0895","observed_orcids":["https://orcid.org/0000-0002-5222-0895"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Filip Braet","raw_affiliation_strings":["Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083476136","display_name":"Ronald De Zanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ronald De Zanger","raw_affiliation_strings":["Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098167658","display_name":"Steffan K\ufffdmmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffan K\ufffdmmer","raw_affiliation_strings":["TopoMetrix, 5403 Betsy Ross Drive, Santa Clara, CA 95054-1192, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TopoMetrix, 5403 Betsy Ross Drive, Santa Clara, CA 95054-1192, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015639828","display_name":"Eddie Wisse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eddie Wisse","raw_affiliation_strings":["Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium","institution_ids":["https://openalex.org/I13469542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039985144"],"corresponding_institution_ids":["https://openalex.org/I13469542"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.5001,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.59247725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"2","first_page":"162","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-endothelial-cells","display_name":"liver endothelial cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/fenestrae","display_name":"fenestrae","score":0.7739999890327454},{"id":"https://openalex.org/keywords/non-contact-atomic-force-microscopy","display_name":"non-contact atomic force microscopy","score":0.9100000262260437},{"id":"https://openalex.org/keywords/amplitude-detection","display_name":"amplitude detection","score":0.5149999856948853},{"id":"https://openalex.org/keywords/image-artifacts","display_name":"image artifacts","score":0.5860000252723694},{"id":"https://openalex.org/keywords/liquid-phase-imaging","display_name":"liquid-phase imaging","score":0.5210000276565552},{"id":"https://openalex.org/keywords/coated-pits","display_name":"coated pits","score":0.625},{"id":"https://openalex.org/keywords/cell-surface-imaging","display_name":"cell surface imaging","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6042360663414001},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.5891165137290955},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.5635857582092285},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5298539996147156},{"id":"https://openalex.org/C2776417487","wikidata":"https://www.wikidata.org/wiki/Q103142","display_name":"Sinusoid","level":2,"score":0.4953655004501343},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.47024527192115784},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44087380170822144},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3707156181335449},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.18706321716308594},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13950908184051514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12690231204032898},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12636518478393555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07999226450920105},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1098(1997)8:2<162::aid-ima3>3.0.co;2-8","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061834038","https://openalex.org/W3036310250","https://openalex.org/W2022158172","https://openalex.org/W1992410996","https://openalex.org/W2743510888","https://openalex.org/W3049349755","https://openalex.org/W2580416834","https://openalex.org/W2623836754","https://openalex.org/W3137331641","https://openalex.org/W3027307579"],"abstract_inverted_index":{"Liver":[0],"sinusoidal":[1,18],"endothelial":[2],"cells":[3,91,193,259],"(LEC)":[4],"contain":[5],"fenestrae,":[6,106],"which":[7,168,282],"control":[8],"the":[9,17,21,25,73,89,99,102,258,267],"exchange":[10],"of":[11,24,30,49,101,105,111,129,144,146,187,199,206,212,223],"fluids,":[12],"solutes,":[13],"and":[14,20,40,46,121,156,176,209,229,237,241,249,263,270,279],"particles":[15],"between":[16],"blood":[19],"microvillous":[22],"surface":[23,29,235],"parenchymal":[26],"cells.":[27],"The":[28,118],"LEC":[31,50,132,178,200,239],"can":[32,51,135],"be":[33,52,136,284],"imaged":[34],"by":[35,60,243,286],"scanning":[36],"electron":[37],"microscopy":[38,43],"(SEM)":[39],"atomic":[41],"force":[42],"(AFM).":[44],"SEM":[45,109],"AFM":[47,181,255],"images":[48,145,198],"used":[53],"to":[54,150,192,226,232,266],"study":[55],"dynamic":[56,272],"changes":[57],"in":[58,133,138,179,202,217],"fenestrae":[59,112,147,278],"comparing":[61],"specimens":[62],"fixed":[63,131],"after":[64],"different":[65,74],"experimental":[66],"treatments.":[67],"In":[68],"this":[69,185],"article,":[70],"we":[71],"report":[72],"results":[75],"obtained":[76,201],"when":[77],"contact":[78,180,195],"(using":[79],"a":[80],"constant":[81],"force)":[82],"or":[83,182],"noncontact":[84,139,166,203],"(amplitude":[85],"detection)":[86],"imaging":[87,128],"on":[88,98],"same":[90],"was":[92,96,163,169],"applied.":[93],"Special":[94],"attention":[95],"paid":[97],"optimalization":[100],"image":[103],"acquisition":[104,143],"because":[107,257],"quality":[108,208],"examinations":[110],"have":[113],"already":[114],"extensively":[115],"been":[116],"described.":[117],"following":[119],"advances":[120],"conclusions":[122],"are":[123,205,210,246,260],"presented":[124],"here:":[125],"1)":[126],"High-resolution":[127],"slightly":[130],"fluid":[134],"performed":[137],"AFM;":[140],"2)":[141],"correct":[142,234],"with":[148,165,173],"regard":[149],"their":[151],"size":[152],"(\u00d8,":[153],"\u00b1200":[154],"nm)":[155],"shape":[157],"(oval,":[158],"without":[159],"deformation)":[160],"under":[161],"liquid":[162],"possible":[164],"AFM,":[167],"hitherto":[170],"only":[171],"feasible":[172],"fixed,":[174],"dried,":[175],"coated":[177,280],"SEM;":[183],"3)":[184],"mode":[186,204],"operation":[188],"is":[189,222],"more":[190],"gentle":[191],"than":[194],"mode;":[196],"4)":[197],"higher":[207],"devoid":[211],"smearing":[213],"artefacts,":[214],"prominently":[215],"present":[216],"contact-mode":[218],"images;":[219],"5)":[220],"it":[221],"great":[224],"importance":[225],"optimize":[227],"feedback":[228],"scan":[230],"parameters":[231],"obtain":[233],"information;":[236],"6)":[238],"isolated":[240],"cultured":[242],"our":[244],"method":[245],"physiologically":[247],"responsive":[248],"represent":[250],"an":[251],"ideal":[252],"object":[253],"for":[254],"studies,":[256],"thin,":[261],"smooth,":[262],"well":[264],"attached":[265],"culture":[268],"substrate":[269],"show":[271],"fine":[273],"structural":[274],"details,":[275],"such":[276],"as":[277],"pits,":[281],"cannot":[283],"seen":[285],"light":[287],"microscopy.":[288],"\u00a9":[289],"1997":[290,303],"John":[291],"Wiley":[292],"&":[293],"Sons,":[294],"Inc.":[295],"Int":[296],"J":[297],"Imaging":[298],"Syst":[299],"Technol,":[300],"8,":[301],"162\u2013167,":[302]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}