{"id":"https://openalex.org/W2016180784","doi":"https://doi.org/10.1016/s0367-326x(99)00117-3","title":"In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines","display_name":"In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2016180784","doi":"https://doi.org/10.1016/s0367-326x(99)00117-3","mag":"2016180784","pmid":"https://pubmed.ncbi.nlm.nih.gov/11449470"},"language":"en","primary_location":{"id":"doi:10.1016/s0367-326x(99)00117-3","doi":"https://doi.org/10.1016/s0367-326x(99)00117-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0367-326x(99)00117-3","pdf_url":null,"source":{"id":"https://openalex.org/S44811770","display_name":"Fitoterapia","issn_l":"0367-326X","issn":["0367-326X","1873-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025919689","display_name":"Fatima Lamchouri","orcid":"https://orcid.org/0000-0002-6711-1050","observed_orcids":["https://orcid.org/0000-0002-6711-1050"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"F. Lamchouri","raw_affiliation_strings":["Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112177624","display_name":"Abdellatif Settaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A. Settaf","raw_affiliation_strings":["Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081773019","display_name":"Yahia Cherrah","orcid":"https://orcid.org/0000-0001-7890-9028","observed_orcids":["https://orcid.org/0000-0001-7890-9028"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Y. Cherrah","raw_affiliation_strings":["Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107826360","display_name":"M. Hassar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M. Hassar","raw_affiliation_strings":["Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie et Toxicologie, Facult\u00e9 de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075362912","display_name":"Mustapha Zemzami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Zemzami","raw_affiliation_strings":["Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Atif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Atif","raw_affiliation_strings":["Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034900025","display_name":"E.B. Nadori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.B. Nadori","raw_affiliation_strings":["Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Contr\u00f4le des Plants (UCP) Dar Es Salam, Direction des Domaines Agricoles, Rabat, Morocco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141958","display_name":"A. Za\u00efd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153608","display_name":"Universit\u00e9 Moulay Ismail de Meknes","ror":"https://ror.org/04cnscd67","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210153608"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A. Zaid","raw_affiliation_strings":["Laboratoire de Biochimie et de Pharmacognosie, Facult\u00e9 des Sciences, Mekn\u00e8s, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie et de Pharmacognosie, Facult\u00e9 des Sciences, Mekn\u00e8s, Morocco","institution_ids":["https://openalex.org/I4210153608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077721655","display_name":"Badia\u00e2 Lyoussi","orcid":"https://orcid.org/0000-0001-6090-6558","observed_orcids":["https://orcid.org/0000-0001-6090-6558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Lyoussi","raw_affiliation_strings":["Laboratoire de Physiologie Animale, Facult\u00e9 des Sciences Dhar Mahraz, F\u00e8s, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie Animale, Facult\u00e9 des Sciences Dhar Mahraz, F\u00e8s, Morocco","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025919689"],"corresponding_institution_ids":["https://openalex.org/I126477371"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":0.557,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.58815532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"71","issue":"1","first_page":"50","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peganum-harmala","display_name":"Peganum harmala","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cell-lysis","display_name":"cell lysis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/seed-extract","display_name":"seed extract","score":0.5550000071525574},{"id":"https://openalex.org/keywords/medullary-carcinoma","display_name":"medullary carcinoma","score":0.5839999914169312},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.7509999871253967},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2780237542","wikidata":"https://www.wikidata.org/wiki/Q94857","display_name":"Peganum harmala","level":2,"score":0.9650423526763916},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.648354172706604},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6281399130821228},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5649783611297607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4897611141204834},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4835795760154724},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.4814555048942566},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.4706159234046936},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4502149224281311},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44937965273857117},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42676177620887756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39744019508361816},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.39438682794570923},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36346107721328735},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.262067973613739},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2593027353286743},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.25862979888916016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22653070092201233},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21328338980674744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11590832471847534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019685","descriptor_name":"Rosales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0367-326x(99)00117-3","doi":"https://doi.org/10.1016/s0367-326x(99)00117-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0367-326x(99)00117-3","pdf_url":null,"source":{"id":"https://openalex.org/S44811770","display_name":"Fitoterapia","issn_l":"0367-326X","issn":["0367-326X","1873-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},{"id":"pmid:11449470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11449470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W90363941","https://openalex.org/W252719534","https://openalex.org/W1989883879","https://openalex.org/W2029683638","https://openalex.org/W2041245611","https://openalex.org/W2043167868","https://openalex.org/W2051994523","https://openalex.org/W2087567168","https://openalex.org/W2098586658","https://openalex.org/W2201764257","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3030309874","https://openalex.org/W2160335998","https://openalex.org/W2288844076","https://openalex.org/W2536510667","https://openalex.org/W110787574","https://openalex.org/W3107868320","https://openalex.org/W2137228698","https://openalex.org/W2922455379","https://openalex.org/W1952571669","https://openalex.org/W3157472612"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}