{"id":"https://openalex.org/W2016178284","doi":"https://doi.org/10.4252/wjsc.v4.i6.53","title":"Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue","display_name":"Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2016178284","doi":"https://doi.org/10.4252/wjsc.v4.i6.53","mag":"2016178284","pmid":"https://pubmed.ncbi.nlm.nih.gov/22993662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3443712"},"language":"en","primary_location":{"id":"doi:10.4252/wjsc.v4.i6.53","doi":"https://doi.org/10.4252/wjsc.v4.i6.53","is_oa":true,"landing_page_url":"https://doi.org/10.4252/wjsc.v4.i6.53","pdf_url":"https://www.wjgnet.com/1948-0210/full/v4/i6/53.htm","source":{"id":"https://openalex.org/S61643540","display_name":"World Journal of Stem Cells","issn_l":"1948-0210","issn":["1948-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1948-0210/full/v4/i6/53.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035545909","display_name":"Shalini Vellasamy","orcid":"https://orcid.org/0000-0001-8004-2996","observed_orcids":["https://orcid.org/0000-0001-8004-2996"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Shalini Vellasamy","raw_affiliation_strings":["Shalini Vellasamy, Pratheep Sandrasaigaran, Sharmili Vidyadaran, Rajesh Ramasamy, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shalini Vellasamy, Pratheep Sandrasaigaran, Sharmili Vidyadaran, Rajesh Ramasamy, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035545909"],"corresponding_institution_ids":["https://openalex.org/I130343225"],"apc_list":null,"apc_paid":null,"fwci":3.0368,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.91828246,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"4","issue":"6","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/human-placenta","display_name":"human placenta","score":0.921999990940094},{"id":"https://openalex.org/keywords/placenta-derived-stem-cells","display_name":"placenta-derived stem cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/stem-cell-isolation","display_name":"stem cell isolation","score":0.824999988079071},{"id":"https://openalex.org/keywords/enzymatic-digestion","display_name":"enzymatic digestion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mechanical-dissociation","display_name":"mechanical dissociation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.7720000147819519},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":1.0},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9160000085830688},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8399999737739563},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8806968927383423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6813610196113586},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6175988912582397},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6105731725692749},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.6024042367935181},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5497676134109497},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5420518517494202},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5409184098243713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4710695147514343},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4292200207710266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34183457493782043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3371293842792511},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1540966033935547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12291756272315979},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.11716794967651367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06140458583831787},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4252/wjsc.v4.i6.53","doi":"https://doi.org/10.4252/wjsc.v4.i6.53","is_oa":true,"landing_page_url":"https://doi.org/10.4252/wjsc.v4.i6.53","pdf_url":"https://www.wjgnet.com/1948-0210/full/v4/i6/53.htm","source":{"id":"https://openalex.org/S61643540","display_name":"World Journal of Stem Cells","issn_l":"1948-0210","issn":["1948-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Stem Cells","raw_type":"journal-article"},{"id":"pmid:22993662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22993662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of stem cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3443712","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3443712/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Stem Cells","raw_type":"Text"},{"id":"pmh:oai:psasir.upm.edu.my:37838","doi":null,"is_oa":false,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/37838/1/37838.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/37838/1/37838.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.4252/wjsc.v4.i6.53","doi":"https://doi.org/10.4252/wjsc.v4.i6.53","is_oa":true,"landing_page_url":"https://doi.org/10.4252/wjsc.v4.i6.53","pdf_url":"https://www.wjgnet.com/1948-0210/full/v4/i6/53.htm","source":{"id":"https://openalex.org/S61643540","display_name":"World Journal of Stem Cells","issn_l":"1948-0210","issn":["1948-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Stem Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016178284.pdf","grobid_xml":"https://content.openalex.org/works/W2016178284.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1965209133","https://openalex.org/W1970600368","https://openalex.org/W1976442043","https://openalex.org/W1982408656","https://openalex.org/W1983259364","https://openalex.org/W1984180661","https://openalex.org/W1991328368","https://openalex.org/W1992935708","https://openalex.org/W1999070656","https://openalex.org/W2007098561","https://openalex.org/W2010573560","https://openalex.org/W2021134616","https://openalex.org/W2022399725","https://openalex.org/W2025371271","https://openalex.org/W2031543667","https://openalex.org/W2035976926","https://openalex.org/W2039742699","https://openalex.org/W2040188417","https://openalex.org/W2044875340","https://openalex.org/W2054727711","https://openalex.org/W2058692258","https://openalex.org/W2059858822","https://openalex.org/W2064090932","https://openalex.org/W2080147837","https://openalex.org/W2083628520","https://openalex.org/W2085491292","https://openalex.org/W2085959104","https://openalex.org/W2087810821","https://openalex.org/W2091395040","https://openalex.org/W2109606739","https://openalex.org/W2117297322","https://openalex.org/W2132028114","https://openalex.org/W2141633761","https://openalex.org/W2144789903","https://openalex.org/W2145775044","https://openalex.org/W2159358845","https://openalex.org/W2159999899","https://openalex.org/W2223494508","https://openalex.org/W2307129397","https://openalex.org/W2410415126"],"related_works":["https://openalex.org/W2531002885","https://openalex.org/W2371781750","https://openalex.org/W4399601577","https://openalex.org/W2567650939","https://openalex.org/W2141633761","https://openalex.org/W2371819415","https://openalex.org/W4393074683","https://openalex.org/W2039742699","https://openalex.org/W2090361558","https://openalex.org/W2368589588"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"the":[3,130,157],"feasibility":[4],"of":[5,42,63,78,83,134,142,199,213],"placenta":[6,26,35,179,205],"tissue":[7,27],"as":[8,92,209],"a":[9,163],"reliable":[10],"and":[11,31,52,58,67,100,109,126,190,218],"efficient":[12],"source":[13,212],"for":[14,40,215],"generating":[15],"mesenchymal":[16,182],"stem":[17,47,131],"cells":[18,73,161],"(MSC).":[19],"METHODS:":[20],"MSC":[21,36,97,175,214],"were":[22,38,74,147,194],"generated":[23,89,176],"from":[24,177],"human":[25,178],"by":[28,76],"enzymatic":[29],"digestion":[30],"mechanical":[32],"dissociation.":[33],"The":[34,60,88],"(PLC-MSC)":[37],"characterized":[39],"expression":[41,51,137,188],"cell":[43,48,79,132,153,168,170,183],"surface":[44,98,184],"markers,":[45],"embryonic":[46],"(ECS)":[49],"gene":[50,187],"their":[53,135,143],"differentiation":[54,192],"ability":[55],"into":[56,107],"adipocytes":[57],"osteocytes.":[59],"immunosuppressive":[61,144],"properties":[62],"PLC-MSC":[64,90,146],"on":[65],"resting":[66,151],"phytohemagglutinin":[68],"(PHA)":[69],"stimulated":[70,159],"allogenic":[71],"T":[72,152,160],"assessed":[75],"means":[77],"proliferation":[80],"via":[81],"incorporation":[82],"tritium":[84],"thymidine":[85],"((3)H-TdR).":[86],"RESULTS:":[87],"appeared":[91],"spindle-shaped":[93],"cells,":[94],"expressed":[95],"common":[96],"markers":[99],"ESC":[101],"transcriptional":[102],"factors.":[103],"They":[104],"also":[105],"differentiated":[106],"adipogenic":[108],"osteogenic":[110],"lineages":[111],"when":[112],"induced.":[113],"However,":[114],"continuous":[115],"cultivation":[116],"up":[117],"to":[118,149,169,196],"passage":[119],"15":[120],"caused":[121],"changes":[122],"in":[123,162],"morphological":[124],"appearance":[125],"cellular":[127],"senescence,":[128],"although":[129],"nature":[133],"protein":[136],"was":[138],"unchanged.":[139],"In":[140,172],"terms":[141],"properties,":[145],"unable":[148],"stimulate":[150],"proliferation;":[154],"they":[155],"inhibited":[156],"PHA":[158],"dose":[164],"dependent":[165],"manner":[166],"through":[167],"contact.":[171],"our":[173],"study,":[174],"exhibited":[180],"similar":[181],"markers;":[185],"MSC-like":[186,191],"pattern":[189],"potential":[193],"comparable":[195],"other":[197],"sources":[198],"MSC.":[200],"CONCLUSION:":[201],"We":[202],"suggest":[203],"that":[204],"tissues":[206],"can":[207],"serve":[208],"an":[210],"alternative":[211],"future":[216],"experimental":[217],"clinical":[219],"studies.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
