{"id":"https://openalex.org/W2016176618","doi":"https://doi.org/10.1248/bpb.28.1635","title":"Protective Effects of Capsaicin against Cisplatin-Induced Nephrotoxicity in Rats","display_name":"Protective Effects of Capsaicin against Cisplatin-Induced Nephrotoxicity in Rats","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2016176618","doi":"https://doi.org/10.1248/bpb.28.1635","mag":"2016176618","pmid":"https://pubmed.ncbi.nlm.nih.gov/16141530"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.28.1635","doi":"https://doi.org/10.1248/bpb.28.1635","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1635","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1635/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1635/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030092466","display_name":"Yuka Shimeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158816","display_name":"Otemae Hospital","ror":"https://ror.org/05m7r3n78","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158816"]},{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Shimeda","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","Department of Pharmacy, KKR Otemae Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]},{"raw_affiliation_string":"Department of Pharmacy, KKR Otemae Hospital","institution_ids":["https://openalex.org/I4210158816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500809","display_name":"Yoshihiko Hirotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Hirotani","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084611086","display_name":"Youko Akimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youko Akimoto","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061436483","display_name":"Kyoko Shindou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Shindou","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","Osaka Faruma Plan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]},{"raw_affiliation_string":"Osaka Faruma Plan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039682115","display_name":"Yoshio Ijiri","orcid":"https://orcid.org/0000-0003-2483-4619","observed_orcids":["https://orcid.org/0000-0003-2483-4619"]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Ijiri","raw_affiliation_strings":["Department of Pharmacy, Osaka Medical College Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Osaka Medical College Hospital","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005080046","display_name":"Takako Nishihori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284808","display_name":"Nara Prefectural Hospital Organization","ror":"https://ror.org/047t1gr18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284808"]},{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takako Nishihori","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","Department of Pharmacy, Prefectural Nara Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]},{"raw_affiliation_string":"Department of Pharmacy, Prefectural Nara Hospital","institution_ids":["https://openalex.org/I4405284808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108772860","display_name":"Kazuhiko Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Tanaka","raw_affiliation_strings":["Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy & Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences","institution_ids":["https://openalex.org/I90237989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3275,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.97614933,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"28","issue":"9","first_page":"1635","last_page":"1638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.4059999883174896},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9670000076293945},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8109999895095825},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/dietary-antioxidants","display_name":"dietary antioxidants","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.907720685005188},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.8507704734802246},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7392371296882629},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.707645058631897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.643132746219635},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.606748104095459},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.603543758392334},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5811220407485962},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5747730731964111},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.526137113571167},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.46965280175209045},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4386172890663147},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38136109709739685},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.37773188948631287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3025617003440857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2523673176765442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18712392449378967},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11233770847320557},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09429910778999329},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014563","descriptor_name":"Urodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.28.1635","doi":"https://doi.org/10.1248/bpb.28.1635","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1635","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1635/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:16141530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16141530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.28.1635","doi":"https://doi.org/10.1248/bpb.28.1635","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1635","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1635/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016176618.pdf","grobid_xml":"https://content.openalex.org/works/W2016176618.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1775749144","https://openalex.org/W1909254787","https://openalex.org/W1940436875","https://openalex.org/W1989375851","https://openalex.org/W1989443167","https://openalex.org/W1990769232","https://openalex.org/W1995292748","https://openalex.org/W1996680733","https://openalex.org/W2001865423","https://openalex.org/W2006370393","https://openalex.org/W2012726316","https://openalex.org/W2014221009","https://openalex.org/W2016205917","https://openalex.org/W2018520574","https://openalex.org/W2033539955","https://openalex.org/W2033889898","https://openalex.org/W2042876453","https://openalex.org/W2049533913","https://openalex.org/W2051005799","https://openalex.org/W2051402829","https://openalex.org/W2057522312","https://openalex.org/W2078500674","https://openalex.org/W2079594476","https://openalex.org/W2089032886","https://openalex.org/W2092718776","https://openalex.org/W2117319789","https://openalex.org/W2139993130","https://openalex.org/W2262733167","https://openalex.org/W4252764622"],"related_works":["https://openalex.org/W2087246360","https://openalex.org/W2117319789","https://openalex.org/W1991352662","https://openalex.org/W1992210660","https://openalex.org/W2076032177","https://openalex.org/W2041846620","https://openalex.org/W2151093913","https://openalex.org/W2000208253","https://openalex.org/W3198202727","https://openalex.org/W2160321809"],"abstract_inverted_index":{"Cisplatin-induced":[0],"nephrotoxicity":[1,36,202],"is":[2],"related":[3],"to":[4,150,173],"an":[5],"increase":[6,143],"in":[7,14,37,78,81,108,129,144,148,206],"lipid":[8,33,204],"peroxidation":[9,34,205],"and":[10,35,97,106,135,140,186,203],"oxygen":[11],"free":[12],"radicals":[13],"a":[15,44,86,141,174],"kidney.":[16],"In":[17,178],"the":[18,23,26,69,82,89,111,119,123,130,151,166,182,187],"present":[19],"study,":[20],"we":[21],"investigated":[22],"effect":[24],"of":[25,47,72,88,184,189],"dietary":[27],"antioxidants,":[28],"capsaicin":[29],"(Cap),":[30],"against":[31,200],"cisplatin-induced":[32,201],"rats.":[38,207],"Nephrotoxicity":[39],"induced":[40,169],"by":[41,66,101,170],"treatment":[42],"with":[43,110],"single":[45],"dose":[46],"cisplatin":[48,73,164,171],"(5":[49],"mg/kg":[50],"body":[51,91],"weight":[52,84],"i.p.).":[53],"The":[54],"animals":[55],"were":[56],"divided":[57],"into":[58],"4":[59],"groups.":[60],"Cap":[61,162,180,196],"(10":[62],"mg/kg/d)":[63],"was":[64],"given":[65],"gavage":[67],"from":[68,122],"same":[70],"day":[71],"injection.":[74],"Cisplatin":[75],"administration":[76],"resulted":[77],"significant":[79,127,142,175],"increases":[80],"kidney":[83,131],"as":[85],"percentage":[87],"total":[90],"weight,":[92],"urine":[93],"volume,":[94],"serum":[95],"creatinine,":[96],"blood":[98],"urea":[99],"nitrogen":[100],"about":[102],"132,":[103],"315,":[104],"797,":[105],"556%":[107],"comparison":[109,149],"control":[112],"rats,":[113],"respectively":[114],"(p":[115,156],"<":[116,157],"0.05).":[117,158],"Also,":[118],"renal":[120,167],"tissue":[121],"cisplatin-treated":[124],"rats":[125],"showed":[126],"decreases":[128],"glutathione":[132],"(GSH)":[133],"content":[134],"superoxide":[136],"dismustase":[137],"(SOD)":[138],"activity":[139],"malondialdehyde":[145],"(MDA)":[146],"production":[147],"values":[152],"at":[153],"0":[154],"h":[155],"Seven":[159],"days":[160],"after":[161],"plus":[163],"treatments,":[165],"damage":[168],"recovered":[172],"statistically":[176],"level.":[177],"addition,":[179],"prevented":[181],"rise":[183],"MDA":[185],"reduction":[188],"SOD":[190],"activities.":[191],"These":[192],"results":[193],"suggest":[194],"that":[195],"has":[197],"protective":[198],"effects":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}