{"id":"https://openalex.org/W2016171370","doi":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","title":"Tiam1 mutations in human renal-cell carcinomas","display_name":"Tiam1 mutations in human renal-cell carcinomas","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2016171370","doi":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","mag":"2016171370","pmid":"https://pubmed.ncbi.nlm.nih.gov/11054665"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064302035","display_name":"Rainer Engers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rainer Engers","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, D\u00fcsseldorf, Germany. engers@med.uni-duesseldorf.de","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, D\u00fcsseldorf, Germany. engers@med.uni-duesseldorf.de","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081234985","display_name":"Thomas P. Zwaka","orcid":"https://orcid.org/0000-0002-9271-2456","observed_orcids":["https://orcid.org/0000-0002-9271-2456"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas P. Zwaka","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061383045","display_name":"Lutz G. Gohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Gohr","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061091984","display_name":"Achim Weber","orcid":"https://orcid.org/0000-0003-0073-3637","observed_orcids":["https://orcid.org/0000-0003-0073-3637"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Achim Weber","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110026032","display_name":"Claus\u2010Dieter Gerharz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus-Dieter Gerharz","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104085350","display_name":"Helmut Erich Gabbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut E. Gabbert","raw_affiliation_strings":["Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine-University, Du\u0308sseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Pathology, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064302035"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.2034,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.76910737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"88","issue":"3","first_page":"369","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.09049999713897705,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiam1","display_name":"Tiam1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ph-domain","display_name":"pleckstrin homology domain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.6669999957084656},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.7101664543151855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7080115079879761},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6373363733291626},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.6206705570220947},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.46440649032592773},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45630449056625366},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44677260518074036},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4428936839103699},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4148104190826416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40800100564956665},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3920131325721741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2970038056373596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2574889659881592},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17309686541557312}],"mesh":[{"descriptor_ui":"D000075684","descriptor_name":"T-Lymphoma Invasion and Metastasis-inducing Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004722","descriptor_name":"Endoribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0215(20001101)88:3<369::aid-ijc8>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11054665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11054665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W6484253","https://openalex.org/W58899900","https://openalex.org/W106628407","https://openalex.org/W188049534","https://openalex.org/W1488720837","https://openalex.org/W1549780802","https://openalex.org/W1566581202","https://openalex.org/W1984967137","https://openalex.org/W1985249096","https://openalex.org/W1987888289","https://openalex.org/W1988706792","https://openalex.org/W1989143807","https://openalex.org/W1993808418","https://openalex.org/W1994155349","https://openalex.org/W2009435420","https://openalex.org/W2019258251","https://openalex.org/W2028204795","https://openalex.org/W2033318513","https://openalex.org/W2037670359","https://openalex.org/W2041121472","https://openalex.org/W2054526083","https://openalex.org/W2092249847","https://openalex.org/W2093226717","https://openalex.org/W2093797917","https://openalex.org/W2125173504","https://openalex.org/W2127529738","https://openalex.org/W2132382863","https://openalex.org/W2139130381","https://openalex.org/W2144026996","https://openalex.org/W2162521796","https://openalex.org/W2170906235","https://openalex.org/W2341137337","https://openalex.org/W2614525914"],"related_works":["https://openalex.org/W2024590066","https://openalex.org/W3007999434","https://openalex.org/W1991661017","https://openalex.org/W58899900","https://openalex.org/W2529205060","https://openalex.org/W2019528050","https://openalex.org/W7096779407","https://openalex.org/W2394160993","https://openalex.org/W1998195598","https://openalex.org/W1982425093"],"abstract_inverted_index":{"Tiam1":[0,27,52,98,197,206,238],"activates":[1],"the":[2,19,48,70,97,108,150,230],"Rho-like":[3],"GTPase":[4],"Rac1,":[5],"and":[6,75,119,142,195],"studies":[7],"indicate":[8],"that":[9,37,174],"Tiam1-Rac1":[10],"signaling":[11],"affects":[12],"invasion":[13],"in":[14,28,59,87,96,107,137,149,187,211,229,240,250],"different":[15,93],"ways":[16],"depending":[17],"on":[18,26,237],"cell":[20,46,82,144],"type":[21],"studied.":[22],"However,":[23],"no":[24,63,85],"investigations":[25],"human":[29,42,131,213,233,241],"tumors":[30,141,242],"have":[31],"been":[32],"reported.":[33],"Here,":[34],"we":[35],"show":[36],"for":[38,116],"4":[39,138],"of":[40,51,73,80,122,126,139,177,182,219,232],"5":[41,92],"renal-cell":[43],"carcinoma":[44],"(RCC)":[45],"lines":[47,83,145],"expression":[49,71],"levels":[50,72],"tended":[53],"to":[54,91,161,199,247],"be":[55,67,162],"inversely":[56],"correlated":[57],"with":[58],"vitro":[60],"invasiveness,":[61],"whereas":[62,192],"obvious":[64],"correlation":[65],"could":[66],"found":[68,136],"between":[69],"Rac1":[74,88],"invasion.":[76],"Subsequent":[77],"mutation":[78,103,133,158,207,216],"analysis":[79,125],"these":[81],"revealed":[84],"mutations":[86,95,239],"but":[89,147],"up":[90],"point":[94],"gene.":[99],"Of":[100],"these,":[101],"1":[102],"(A441G)":[104,208],"was":[105,135,170,209],"located":[106],"NH2-terminal":[109],"pleckstrin":[110],"homology":[111],"domain,":[112],"which":[113],"is":[114],"essential":[115],"membrane":[117],"localization":[118],"functional":[120],"activity":[121],"Tiam1.":[123],"By":[124,155],"an":[127],"additional":[128],"30":[129],"primary":[130],"RCCs,":[132],"A441G":[134,159],"35":[140],"tumor":[143,251],"(11.5%)":[146],"not":[148],"respective":[151],"normal":[152],"kidney":[153],"tissues.":[154],"enzymatic":[156],"digestion,":[157],"proved":[160],"heterozygous,":[163],"suggesting":[164],"a":[165,188,204,226],"dominant":[166],"active":[167],"function.":[168],"This":[169,215],"supported":[171],"by":[172],"showing":[173],"stable":[175],"over-expression":[176],"mutated":[178],"A441G-Tiam1":[179],"induced":[180,217],"transformation":[181,218],"NIH3T3":[183,220],"cells,":[184],"as":[185],"determined":[186],"colony":[189],"formation":[190],"assay,":[191],"empty":[193],"vector":[194],"wild-type":[196],"failed":[198],"do":[200],"so.":[201],"In":[202],"conclusion,":[203],"distinct":[205],"identified":[210],"several":[212],"RCCs.":[214,234],"cells":[221],"and,":[222],"hence,":[223],"might":[224,243],"play":[225],"major":[227],"role":[228,249],"progression":[231],"Further":[235],"analyses":[236],"give":[244],"new":[245],"clues":[246],"their":[248],"progression.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
