{"id":"https://openalex.org/W2016162191","doi":"https://doi.org/10.1055/s-2006-921508","title":"Gene Expression Profiles of Breast Cancer Obtained from Core Cut Biopsies Before Neoadjuvant Docetaxel, Adriamycin, and Cyclophoshamide Chemotherapy Correlate with Routine Prognostic Markers and Could Be Used to Identify Predictive Signatures","display_name":"Gene Expression Profiles of Breast Cancer Obtained from Core Cut Biopsies Before Neoadjuvant Docetaxel, Adriamycin, and Cyclophoshamide Chemotherapy Correlate with Routine Prognostic Markers and Could Be Used to Identify Predictive Signatures","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2016162191","doi":"https://doi.org/10.1055/s-2006-921508","mag":"2016162191","pmid":"https://pubmed.ncbi.nlm.nih.gov/16673249"},"language":"en","primary_location":{"id":"doi:10.1055/s-2006-921508","doi":"https://doi.org/10.1055/s-2006-921508","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-921508","pdf_url":null,"source":{"id":"https://openalex.org/S79069585","display_name":"Zentralblatt f\u00fcr Gyn\u00e4kologie","issn_l":"0044-4197","issn":["0044-4197","1438-9762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320676","host_organization_name":"Johann Ambrosius Barth Verlag","host_organization_lineage":["https://openalex.org/P4310320676"],"host_organization_lineage_names":["Johann Ambrosius Barth Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zentralblatt f\u00fcr Gyn\u00e4kologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038243095","display_name":"Achim Rody","orcid":"https://orcid.org/0000-0001-5904-0486","observed_orcids":["https://orcid.org/0000-0001-5904-0486"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Rody","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany. achim.rody@em.uni-frankfurt.de","Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany. achim.rody@em.uni-frankfurt.de","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024589782","display_name":"Thomas Karn","orcid":"https://orcid.org/0000-0002-3264-6573","observed_orcids":["https://orcid.org/0000-0002-3264-6573"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Karn","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083804925","display_name":"Regine G\u00e4tje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. G\u00e4tje","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075403724","display_name":"K. Kourtis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kourtis","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110911891","display_name":"G\u03cbnter von Minckwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Minckwitz","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087559224","display_name":"Sibylle Loibl","orcid":"https://orcid.org/0000-0001-6488-4958","observed_orcids":["https://orcid.org/0000-0001-6488-4958"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Loibl","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032904905","display_name":"Marc Munnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Munnes","raw_affiliation_strings":["Bayer Healthcare, Leverkusen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Healthcare, Leverkusen, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039077602","display_name":"Eugen Ruckh\u00e4berle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Ruckh\u00e4berle","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026280934","display_name":"Uwe Holtrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Holtrich","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102928611","display_name":"M. Kaufmann","orcid":"https://orcid.org/0009-0000-6818-3761","observed_orcids":["https://orcid.org/0009-0000-6818-3761"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kaufmann","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110880920","display_name":"Andre Ahr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Ahr","raw_affiliation_strings":["Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, J.-W.-Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5234,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82010115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"128","issue":"2","first_page":"76","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/core-needle-biopsy","display_name":"core needle biopsy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/predictive-gene-signature","display_name":"predictive gene signature","score":0.6840000152587891},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6859999895095825},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5950000286102295},{"id":"https://openalex.org/keywords/microarray-data-quality","display_name":"microarray data quality","score":0.4390000104904175},{"id":"https://openalex.org/keywords/receptor-switching","display_name":"receptor switching","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7658679485321045},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7611042261123657},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.7035852670669556},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6367089748382568},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5640079379081726},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5578519105911255},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5451067090034485},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4796077013015747},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.42253583669662476},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4115979075431824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4097209870815277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40949636697769165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3545720875263214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35157540440559387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29353341460227966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13172000646591187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-921508","doi":"https://doi.org/10.1055/s-2006-921508","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-921508","pdf_url":null,"source":{"id":"https://openalex.org/S79069585","display_name":"Zentralblatt f\u00fcr Gyn\u00e4kologie","issn_l":"0044-4197","issn":["0044-4197","1438-9762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320676","host_organization_name":"Johann Ambrosius Barth Verlag","host_organization_lineage":["https://openalex.org/P4310320676"],"host_organization_lineage_names":["Johann Ambrosius Barth Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zentralblatt f\u00fcr Gyn\u00e4kologie","raw_type":"journal-article"},{"id":"pmid:16673249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16673249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zentralblatt fur Gynakologie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W35647293","https://openalex.org/W2050059533","https://openalex.org/W2061423409","https://openalex.org/W2091907178","https://openalex.org/W2096301110","https://openalex.org/W2099721691","https://openalex.org/W2109079833","https://openalex.org/W2131291033","https://openalex.org/W2131994307","https://openalex.org/W2140486627","https://openalex.org/W2160450758"],"related_works":["https://openalex.org/W2223651088","https://openalex.org/W2956170209","https://openalex.org/W2051862972","https://openalex.org/W2264105878","https://openalex.org/W1541754138","https://openalex.org/W2159435859","https://openalex.org/W1866015136","https://openalex.org/W1488389597","https://openalex.org/W2122446147","https://openalex.org/W1978297697"],"abstract_inverted_index":{"Background:":[0],"Neoadjuvant":[1],"administration":[2],"of":[3,37,70,79,82,92,114,116,130,178,223,232,287,317,348,388,400],"chemotherapy":[4,159],"provides":[5],"a":[6,31,250,285],"unique":[7],"opportunity":[8],"to":[9,12,67,144,167,267,297,377,392],"monitor":[10],"response":[11,19,143,380],"treatment":[13,369],"in":[14,302,329,381,676,699,724],"breast":[15,83],"cancer":[16,84,179],"and":[17,39,51,86,100,120,140,173,176,198,237,259,299,307,321],"assesses":[18],"exactly.":[20],"Global":[21],"gene":[22,76,132,273,365],"expression":[23,65,77,96,115,199,235,289,339],"profiling":[24,200,236],"by":[25,136,263,344],"microarrays":[26],"has":[27],"been":[28],"used":[29,214],"as":[30,102,104,134,261],"valuable":[32],"tool":[33],"for":[34,97,107,142,192,215,234,243,290,397],"the":[35,90,93,112,127,161,224,268,382,386,398],"identification":[36],"prognostic":[38,131,314,358],"predictive":[40,128,396],"marker":[41,315,372,394],"genes.":[42],"Even":[43],"though":[44],"this":[45,71],"technology":[46],"is":[47],"now":[48],"wide":[49],"spread":[50],"relatively":[52],"standardized,":[53],"there":[54],"are":[55,374],"only":[56],"few":[57],"data":[58,78,240,271,355],"available":[59],"which":[60],"compare":[61],"established":[62],"parameters":[63],"with":[64,89,183,252,368],"values":[66],"determine":[68],"reliability":[69],"method.":[72],"Therefore":[73],"we":[74,125],"analyzed":[75,111,262],"pretreatment":[80],"biopsies":[81,150,182,225],"patients":[85,155],"compared":[87,266],"them":[88],"results":[91,335],"immunohistochemical":[94],"receptor":[95,254,288],"ER/":[98],"PR":[99,172,258,292,566,659,689],"Her-2,":[101,491],"well":[103],"FISH":[105],"testing":[106],"HER-2":[108,294],"amplification.":[109],"We":[110,282],"change":[113],"these":[117],"markers":[118,359],"before":[119],"after":[121],"neoadjuvant":[122,145,157,352,383],"chemotherapy.":[123,146,353],"Furthermore":[124],"evaluated":[126],"significance":[129],"signatures":[133],"described":[135],"Sorlie,":[137,318,518,714],"van't":[138,319,519,715],"Veer":[139,320,520,716],"Ahr":[141,322,522,718],"Methods:":[147],"Pretherapeutic":[148],"core":[149],"were":[151,164,190,241,265],"obtained":[152,242,350],"from":[153,272,295,327],"70":[154,540],"undergoing":[156],"TAC":[158],"within":[160],"GEPARTRIO-trial.":[162],"Samples":[163],"characterized":[165],"according":[166],"standard":[168],"pathology":[169],"including":[170],"ER,":[171,291,565,658,688],"HER2":[174,260],"IHC":[175],"amount":[177],"cells.":[180],"Only":[181],"more":[184,275],"than":[185,220,276],"80":[186,587],"%":[187,278,588,680],"tumor":[188,379],"cells":[189],"considered":[191],"further":[193],"examination.":[194],"RNA":[195,233],"was":[196,213,280],"isolated":[197],"performed":[201],"using":[202,345],"Affymetrix":[203,598],"Hg":[204,599],"U133":[205,600],"Arrays":[206],"(22":[207,602],"500":[208,603],"genes).":[209],"GeneData's":[210],"Expressionist":[211,613],"software":[212],"bioinformatic":[216],"analyses.":[217],"Results:":[218],"More":[219],"two":[221],"thirds":[222],"yielded":[226],"sufficient":[227],"amounts":[228,347],"(>":[229,626],"5":[230,627],"\u00b5g)":[231,628],"high":[238],"quality":[239],"50":[244,636],"samples.":[245],"Unsupervised":[246],"clustering":[247,646],"broadly":[248],"revealed":[249],"correlation":[251],"hormone":[253],"status.":[255],"When":[256],"ER-\u03b1,":[257],"immunohistochemistry":[264],"corresponding":[269],"mRNA":[270],"chips":[274],"90":[277,679],"concordance":[279],"observed.":[281],"could":[283,323],"observe":[284],"switch":[286],"or":[293],"positive":[296],"negative":[298],"vice":[300],"versa":[301],"16/35":[303,700],"cases":[304,309],"(45.7":[305],"%)":[306,311,703,708],"5/22":[308,705],"(22.7":[310],"respectively.":[312],"The":[313],"sets":[316,366,373,395],"not":[324,375],"discriminate":[325],"responders":[326],"non-responders":[328],"our":[330],"patient":[331],"group.":[332],"Conclusions:":[333],"Our":[334],"demonstrate":[336],"that":[337],"reliable":[338],"profiles":[340],"can":[341],"be":[342],"achieved":[343],"limited":[346],"tissue":[349],"during":[351],"Microarray":[354],"capture":[356],"conventional":[357],"but":[360],"might":[361],"contain":[362],"additional":[363],"informative":[364,759],"correlated":[367],"outcome.":[370],"Prognostic":[371],"suitable":[376],"predict":[378],"setting,":[384],"suggesting":[385],"necessity":[387],"class":[389],"prediction":[390],"methods":[391],"identify":[393],"type":[399],"therapy":[401],"used.":[402],"Zusammenfassung":[403],"Hintergrund:":[404],"Die":[405,553,606,654,710,744],"neoadjuvante":[406],"Chemotherapie":[407,509,778],"des":[408,526,570,597],"Mammakarzinoms":[409],"bietet":[410],"die":[411,417,454,464,501,543,576,749,761,783,792],"einzigartige":[412],"M\u00f6glichkeit,":[413],"das":[414,772],"Ansprechen":[415],"auf":[416,528],"Therapie":[418,795],"zu":[419,423,470,641,730,796],"beobachten":[420],"und":[421,436,446,481,490,506,521,567,660,670,696,717,754],"exakt":[422],"monitoren.":[424],"Globale":[425],"Genexpressionsanalysen":[426],"durch":[427],"DNA-Chiptechnologie":[428],"werden":[429],"als":[430,586,618,678],"wertvolles":[431],"Hilfsmittel":[432],"zur":[433,629],"Identifizierung":[434],"prognostischer":[435],"pr\u00e4diktiver":[437],"Gensignaturen":[438],"eingesetzt.":[439],"Obwohl":[440],"diese":[441],"Technik":[442],"inzwischen":[443],"weit":[444],"verbreitet":[445],"standardisiert":[447],"ist,":[448],"sind":[449,525,768],"nur":[450,579],"wenige":[451],"Daten":[452,640],"verf\u00fcgbar,":[453],"gut":[455],"etablierte":[456],"Marker":[457,504],"mit":[458,482,581,610,651,663,762],"den":[459,483,664],"jeweiligen":[460],"Expressionswerten":[461],"vergleichen,":[462],"um":[463],"Zuverl\u00e4ssigkeit":[465],"dieser":[466,503],"Methode":[467],"besser":[468],"einsch\u00e4tzen":[469],"k\u00f6nnen.":[471],"Daher":[472],"haben":[473],"wir":[474],"Genexpressionsdaten":[475,738,745],"pr\u00e4therapeutischer":[476],"Stanzbiopsien":[477,537,580,622],"von":[478,488,517,539,564,584,635,657,687,692,713,728],"Mammakarzinompatientinnen":[479],"analysiert":[480],"Ergebnissen":[484],"der":[485,493,550,558,561,611,667,674,681,685,725,776],"immunhistochemischen":[486,562],"Rezeptorexpression":[487,686],"ER/PR":[489],"sowie":[492,569],"FISH-Analyse":[494],"bez\u00fcglich":[495],"einer":[496,545],"Her-2-Amplifikation":[497],"verglichen.":[498],"Weiterhin":[499],"wurde":[500,592,662,698],"Expressions\u00e4nderung":[502],"vor":[505],"nach":[507,694],"neoadjuvanter":[508],"untersucht.":[510,572],"Etablierte":[511],"prognostische":[512],"Gensignaturen,":[513],"wie":[514],"sie":[515],"bereits":[516],"beschrieben":[523],"wurden,":[524],"Weiteren":[527],"ihre":[529],"pr\u00e4diktive":[530,789],"Wertigkeit":[531],"hin":[532],"untersucht":[533],"worden.":[534],"Methoden:":[535],"Pr\u00e4therapeutische":[536],"wurden":[538,555,574],"Patientinnen":[541],"erhalten,":[542],"sich":[544],"neoadjuvanten":[546,777],"TAC-Chemotherapie":[547],"im":[548,556,774],"Rahmen":[549,557,775],"GEPARTRIO-Studie":[551],"unterzogen.":[552],"Proben":[554,637],"Routinepathologie":[559],"hinsichtlich":[560],"Expression":[563,656,675],"Her-2":[568,661,691],"Tumorzellanteils":[571],"Es":[573],"f\u00fcr":[575,791],"weitere":[577],"Analyse":[578,608],"einem":[582],"Tumorzellgehalt":[583],"mehr":[585,617,677],"verwendet.":[589],"Nach":[590],"RNA-Isolation":[591],"ein":[593],"Genexpressionsprofil":[594],"unter":[595],"Verwendung":[596],"arrays":[601],"Gene)":[604],"erstellt.":[605],"bioinformatische":[607],"erfolgte":[609],"GeneData":[612],"Software.":[614],"Ergebnisse:":[615],"Von":[616],"zwei":[619],"Drittel":[620],"aller":[621],"konnten":[623],"ausreichende":[624],"RNA-Mengen":[625],"Genexpressionsanalyse":[630],"gewonnen":[631],"werden,":[632],"so":[633,780],"dass":[634,736,781],"qualitativ":[638],"hochwertige":[639],"erhalten":[642],"waren.":[643],"Ein":[644],"unsupervised":[645],"erbrachte":[647],"eine":[648,672],"hohe":[649],"Korrelation":[650],"dem":[652,763],"Hormonrezeptorstatus.":[653],"immunhistochemische":[655],"korrespondierenden":[665],"mRNA-Daten":[666],"Chipanalyse":[668],"verglichen":[669],"zeigte":[671],"Konkordanz":[673],"F\u00e4lle.":[682],"Eine":[683],"Ver\u00e4nderung":[684],"oder":[690],"positiv":[693],"negativ":[695],"umgekehrt":[697],"F\u00e4llen":[701,706],"(45,7":[702],"bzw.":[704],"(22,7":[707],"beobachtet.":[709],"prognostischen":[711],"Markersets":[712,767,790],"waren":[719],"innerhalb":[720],"unseres":[721],"Patientenkollektivs":[722],"nicht":[723,770],"Lage,":[726],"responder":[727],"non-respondern":[729],"unterscheiden.":[731],"Schlussfolgerung:":[732],"Unsere":[733],"Ergebnisse":[734],"zeigen,":[735],"zuverl\u00e4ssige":[737],"aus":[739],"limitiertem":[740],"Tumorgewebe":[741],"erh\u00e4ltlich":[742],"sind.":[743],"spiegeln":[746],"zum":[747],"Einen":[748],"konventionellen":[750],"Prognosefaktoren":[751],"zuverl\u00e4ssig":[752],"wieder":[753],"liefern":[755],"dar\u00fcber":[756],"hinaus":[757],"zus\u00e4tzliche":[758],"Gensets,":[760],"Therapieansprechen":[764],"korrelieren.":[765],"Prognostische":[766],"allerdings":[769],"geeignet,":[771],"Tumoransprechen":[773],"vorherzusagen,":[779],"dies":[782],"Notwendigkeit":[784],"unterstreicht,":[785],"mittels":[786],"\u201eclass":[787],"prediction\u201d-Methoden":[788],"eingesetzte":[793],"spezifische":[794],"identifizieren.":[797]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
