{"id":"https://openalex.org/W2016158936","doi":"https://doi.org/10.2174/1573402111309010007","title":"The Genetics of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease (ADPKD)","display_name":"The Genetics of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease (ADPKD)","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W2016158936","doi":"https://doi.org/10.2174/1573402111309010007","mag":"2016158936","pmid":"https://pubmed.ncbi.nlm.nih.gov/23971643","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047565"},"language":"en","primary_location":{"id":"doi:10.2174/1573402111309010007","doi":"https://doi.org/10.2174/1573402111309010007","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573402111309010007","pdf_url":null,"source":{"id":"https://openalex.org/S116387668","display_name":"Current Hypertension Reviews","issn_l":"1573-4021","issn":["1573-4021","1875-6506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Hypertension Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047565","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000198802","display_name":"Sandro Rossetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandro Rossetti","raw_affiliation_strings":["Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002238355","display_name":"Peter C. Harris","orcid":"https://orcid.org/0000-0002-5304-6593","observed_orcids":["https://orcid.org/0000-0002-5304-6593"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter C. Harris","raw_affiliation_strings":["Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 5590, USA","Nephrology and Hypertension"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 5590, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Nephrology and Hypertension","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002238355"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":2.4264,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88384792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"37","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.4950999915599823,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.4950999915599823,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.4580000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/intracranial-aneurysm","display_name":"intracranial aneurysm","score":0.9369999766349792},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vascular-complications","display_name":"vascular complications","score":0.9100000262260437},{"id":"https://openalex.org/keywords/polycystin-1","display_name":"polycystin-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/polycystin-2","display_name":"polycystin-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/pkd1-mutations","display_name":"PKD1 mutations","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6209999918937683},{"id":"https://openalex.org/keywords/arterial-remodeling","display_name":"arterial remodeling","score":0.7260000109672546},{"id":"https://openalex.org/keywords/multiplex-families","display_name":"multiplex families","score":0.7009999752044678},{"id":"https://openalex.org/keywords/presymptomatic-screening","display_name":"presymptomatic screening","score":0.8870000243186951},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C100773827","wikidata":"https://www.wikidata.org/wiki/Q82302467","display_name":"PKD1","level":4,"score":0.8986644744873047},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.8619239926338196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7355124950408936},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.5242869257926941},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5059306025505066},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49999475479125977},{"id":"https://openalex.org/C2776908417","wikidata":"https://www.wikidata.org/wiki/Q1331116","display_name":"Alport syndrome","level":4,"score":0.4863220155239105},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4794986844062805},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4660789668560028},{"id":"https://openalex.org/C120599132","wikidata":"https://www.wikidata.org/wiki/Q602889","display_name":"Multiplex ligation-dependent probe amplification","level":4,"score":0.4471578001976013},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3954458236694336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39385437965393066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31000956892967224},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.24069634079933167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22254431247711182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19198575615882874},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.14696204662322998},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1573402111309010007","doi":"https://doi.org/10.2174/1573402111309010007","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573402111309010007","pdf_url":null,"source":{"id":"https://openalex.org/S116387668","display_name":"Current Hypertension Reviews","issn_l":"1573-4021","issn":["1573-4021","1875-6506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Hypertension Reviews","raw_type":"journal-article"},{"id":"pmid:23971643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23971643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current hypertension reviews","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3023504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047565","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4047565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Hypertens Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3023504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047565","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5114183716","display_name":"Mutations detection and classification in ADPKD","funder_award_id":"R21DK083669","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5546013096","display_name":null,"funder_award_id":"DK83669","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6984968209","display_name":null,"funder_award_id":"DK58816","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G792516468","display_name":"Mayo Translational PKD Center (MTPC)","funder_award_id":"P30DK090728","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000864643","display_name":"ADPKD: Disease Spectrum & Genotype-Phenotype Correlations","funder_award_id":"R01DK058816","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W1543651946","https://openalex.org/W1551136355","https://openalex.org/W1595476093","https://openalex.org/W1964184380","https://openalex.org/W1964196602","https://openalex.org/W1966359454","https://openalex.org/W1966768793","https://openalex.org/W1969043608","https://openalex.org/W1973147715","https://openalex.org/W1974451205","https://openalex.org/W1980339876","https://openalex.org/W1980732135","https://openalex.org/W1984189068","https://openalex.org/W1990249568","https://openalex.org/W1990585115","https://openalex.org/W1993587642","https://openalex.org/W1993944338","https://openalex.org/W1995061848","https://openalex.org/W1995182581","https://openalex.org/W1997369440","https://openalex.org/W1999374220","https://openalex.org/W2001287863","https://openalex.org/W2005026678","https://openalex.org/W2005702003","https://openalex.org/W2007582483","https://openalex.org/W2008430491","https://openalex.org/W2008589258","https://openalex.org/W2008777092","https://openalex.org/W2010411387","https://openalex.org/W2012159432","https://openalex.org/W2013770853","https://openalex.org/W2021793145","https://openalex.org/W2021855028","https://openalex.org/W2023371427","https://openalex.org/W2024220927","https://openalex.org/W2024316593","https://openalex.org/W2026959390","https://openalex.org/W2027163349","https://openalex.org/W2027344253","https://openalex.org/W2027807256","https://openalex.org/W2028811455","https://openalex.org/W2029965129","https://openalex.org/W2031148468","https://openalex.org/W2032674277","https://openalex.org/W2036198235","https://openalex.org/W2038461636","https://openalex.org/W2039131859","https://openalex.org/W2041098735","https://openalex.org/W2046976802","https://openalex.org/W2050483556","https://openalex.org/W2051176990","https://openalex.org/W2054351373","https://openalex.org/W2055373515","https://openalex.org/W2056957424","https://openalex.org/W2060253847","https://openalex.org/W2062699991","https://openalex.org/W2063307775","https://openalex.org/W2065010189","https://openalex.org/W2065928247","https://openalex.org/W2074151559","https://openalex.org/W2078415207","https://openalex.org/W2078588254","https://openalex.org/W2083134643","https://openalex.org/W2084178313","https://openalex.org/W2084289371","https://openalex.org/W2085346322","https://openalex.org/W2091948921","https://openalex.org/W2094943913","https://openalex.org/W2095947738","https://openalex.org/W2097936595","https://openalex.org/W2099136866","https://openalex.org/W2099346627","https://openalex.org/W2099500949","https://openalex.org/W2102869131","https://openalex.org/W2103557245","https://openalex.org/W2104283241","https://openalex.org/W2107182207","https://openalex.org/W2108799808","https://openalex.org/W2111016195","https://openalex.org/W2112070008","https://openalex.org/W2112284440","https://openalex.org/W2113859387","https://openalex.org/W2114360920","https://openalex.org/W2116699674","https://openalex.org/W2118994076","https://openalex.org/W2123332237","https://openalex.org/W2125633197","https://openalex.org/W2127298838","https://openalex.org/W2128407302","https://openalex.org/W2130211846","https://openalex.org/W2138298557","https://openalex.org/W2142672125","https://openalex.org/W2143287752","https://openalex.org/W2145613550","https://openalex.org/W2148935969","https://openalex.org/W2149215393","https://openalex.org/W2152162813","https://openalex.org/W2154643490","https://openalex.org/W2164628127","https://openalex.org/W2165085541","https://openalex.org/W2165329455","https://openalex.org/W2166718853","https://openalex.org/W2166882617","https://openalex.org/W2169164452","https://openalex.org/W2170326618","https://openalex.org/W2182914835","https://openalex.org/W2546504291","https://openalex.org/W4232454788","https://openalex.org/W4252102346"],"related_works":["https://openalex.org/W4389618037","https://openalex.org/W2233303500","https://openalex.org/W1935323592","https://openalex.org/W7130829321","https://openalex.org/W7202138504","https://openalex.org/W7166856825","https://openalex.org/W4236211958","https://openalex.org/W283492250","https://openalex.org/W4307645203","https://openalex.org/W2761518903"],"abstract_inverted_index":{"The":[0,199],"most":[1],"important":[2,237],"extra-renal":[3],"manifestation":[4],"of":[5,14,23,61,75,82,104,118,143,157,168,178,191,195,201,205,232],"autosomal":[6],"dominant":[7],"polycystic":[8],"kidney":[9],"disease":[10],"(ADPKD)":[11],"in":[12,32,46,50,55,78,92,111,121,186,220],"terms":[13],"debilitating":[15],"injury":[16],"and":[17,27,54,89,96,99,126,154,189,217,225,244],"premature":[18],"death":[19],"is":[20,65,211],"the":[21,51,63,73,83,97,122,140,176,187,192,202],"development":[22,110,177,200],"intracranial":[24],"aneurysms":[25],"(IAs)":[26],"other":[28,218],"vascular":[29,93,123,149],"complications,":[30],"resulting":[31],"subarachnoid":[33],"hemorrhage":[34],"(SAH).":[35],"IAs":[36,161],"are":[37],"found":[38],"at":[39],"a":[40,58,115,166],"rate":[41],"approximately":[42],"five":[43,70],"times":[44],"higher":[45],"ADPKD":[47,84,163,221],"patients":[48,56,128,136,240],"than":[49],"general":[52],"population":[53],"with":[57,137,160,223],"family":[59],"history":[60],"SAH/IAs":[62],"frequency":[64],"elevated":[66],"further":[67],"three":[68],"to":[69,108,132,139,214],"times,":[71],"indicating":[72],"importance":[74],"genetic":[76,203],"factors":[77,174],"its":[79],"etiology.":[80],"Expression":[81],"gene":[85],"products,":[86],"polycystin-1":[87],"(PKD1)":[88],"polycystin-2":[90],"(PKD2),":[91],"smooth":[94],"muscle":[95],"endothelium,":[98],"evidence":[100],"that":[101,170],"reduced":[102],"levels":[103],"these":[105,119,216],"proteins":[106,120,182],"leads":[107],"IA":[109,227],"mouse":[112],"models,":[113],"suggests":[114],"direct":[116],"role":[117],"disease.":[124],"PKD1":[125,144],"PKD2":[127],"seem":[129],"equally":[130],"likely":[131,147],"develop":[133],"IAs,":[134],"while":[135],"mutations":[138],"5'":[141],"half":[142],"may":[145,171],"more":[146],"have":[148,164,184],"complications.":[150],"Genome":[151],"wide":[152],"association":[153],"candidate":[155,181],"studies":[156],"multiplex":[158,224],"families":[159,222],"without":[162],"identified":[165],"number":[167],"genes/proteins":[169],"be":[172,236],"risk":[173],"for":[175,238,241],"IAs.":[179],"These":[180],"largely":[183],"roles":[185],"maintenance":[188],"remodeling":[190],"arterial":[193],"wall":[194],"small":[196],"brain":[197],"arteries.":[198],"methodologies":[204],"massively":[206],"parallel":[207],"sequencing":[208],"mean":[209],"it":[210],"now":[212],"possible":[213],"test":[215],"candidates":[219],"singleton":[226],"cases.":[228],"Identifying":[229],"strong":[230],"modifiers":[231],"this":[233],"phenotype":[234],"will":[235],"prioritizing":[239],"presymptomatic":[242],"screening":[243],"interventions.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}