{"id":"https://openalex.org/W2016156155","doi":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","title":"Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity","display_name":"Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity","publication_year":2009,"publication_date":"2009-05-21","ids":{"openalex":"https://openalex.org/W2016156155","doi":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","mag":"2016156155","pmid":"https://pubmed.ncbi.nlm.nih.gov/19490068"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2362.2009.02170.x","doi":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110070277","display_name":"Daniela Sporrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Sporrer","raw_affiliation_strings":["Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany","Regensburg University Hospital, Regensburg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany;","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026110715","display_name":"Markus Weber","orcid":"https://orcid.org/0000-0001-8203-0382","observed_orcids":["https://orcid.org/0000-0001-8203-0382"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Weber","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055292231","display_name":"Josef Wanninger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Wanninger","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000694398","display_name":"Johanna Weigert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Weigert","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080111727","display_name":"Michael Neumeier","orcid":"https://orcid.org/0000-0002-9601-7477","observed_orcids":["https://orcid.org/0000-0002-9601-7477"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Neumeier","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079843787","display_name":"Fabian St\u00f6gbauer","orcid":"https://orcid.org/0000-0002-8897-5165","observed_orcids":["https://orcid.org/0000-0002-8897-5165"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. St\u00f6gbauer","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057711626","display_name":"Evelyn Lieberer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Lieberer","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111310961","display_name":"M. Bala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Bala","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110756238","display_name":"Andreas K\u00f6pp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Kopp","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045979215","display_name":"Andr\u00e9as Sch\u00e4ffler","orcid":"https://orcid.org/0009-0008-2287-0628","observed_orcids":["https://orcid.org/0009-0008-2287-0628"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Sch\u00e4ffler","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075612423","display_name":"Christa Buechler","orcid":"https://orcid.org/0000-0002-5635-3994","observed_orcids":["https://orcid.org/0000-0002-5635-3994"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"C. Buechler","raw_affiliation_strings":["Regensburg University Hospital, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regensburg University Hospital, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075612423"],"corresponding_institution_ids":["https://openalex.org/I3129555431"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":3.3613,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.92224982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"8","first_page":"671","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd163","display_name":"CD163","score":0.9990000128746033},{"id":"https://openalex.org/keywords/soluble-cd163","display_name":"soluble CD163","score":0.9959999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amp-kinase","display_name":"AMP kinase","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8510000109672546},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2775858924","wikidata":"https://www.wikidata.org/wiki/Q18034009","display_name":"CD163","level":4,"score":0.9101840257644653},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8085355162620544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7070275545120239},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.689174473285675},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6778504252433777},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5188294649124146},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5155934691429138},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4756723940372467},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4620159864425659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4424195885658264},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.43997785449028015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3734337091445923},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.25510382652282715},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2395998239517212},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10992345213890076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06667730212211609}],"mesh":[{"descriptor_ui":"D000098902","descriptor_name":"CD163 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2362.2009.02170.x","doi":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2362.2009.02170.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:19490068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19490068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:66999","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/66999/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1535567348","https://openalex.org/W1565979608","https://openalex.org/W1974343528","https://openalex.org/W1978321463","https://openalex.org/W1980866542","https://openalex.org/W1981261500","https://openalex.org/W1984595457","https://openalex.org/W1985929369","https://openalex.org/W1986225008","https://openalex.org/W2032475900","https://openalex.org/W2034542824","https://openalex.org/W2034877596","https://openalex.org/W2035499788","https://openalex.org/W2036813330","https://openalex.org/W2039831614","https://openalex.org/W2050441306","https://openalex.org/W2061151627","https://openalex.org/W2075169748","https://openalex.org/W2077861475","https://openalex.org/W2078927721","https://openalex.org/W2080044245","https://openalex.org/W2080981566","https://openalex.org/W2081450116","https://openalex.org/W2099458192","https://openalex.org/W2101406299","https://openalex.org/W2127429864","https://openalex.org/W2129224427","https://openalex.org/W2133950776","https://openalex.org/W2134524309","https://openalex.org/W2139788111","https://openalex.org/W2142020464","https://openalex.org/W2143009142","https://openalex.org/W2148672166","https://openalex.org/W2152718355","https://openalex.org/W2152887115","https://openalex.org/W2161688306","https://openalex.org/W2166280318","https://openalex.org/W2167485774","https://openalex.org/W2168553115"],"related_works":["https://openalex.org/W2037666800","https://openalex.org/W139048089","https://openalex.org/W1986225008","https://openalex.org/W1580704131","https://openalex.org/W1532108414","https://openalex.org/W2755846058","https://openalex.org/W1967771101","https://openalex.org/W2184224678","https://openalex.org/W2161688306","https://openalex.org/W2971133814"],"abstract_inverted_index":{"BACKGROUND:":[0],"CD163":[1,50,105,152,221,233],"is":[2,11,17],"a":[3,91,178],"monocyte/macrophage":[4],"specific":[5],"receptor":[6],"whose":[7],"soluble":[8],"form":[9],"(sCD163)":[10],"elevated":[12,166,226],"in":[13,59,118,125,141,155,161,227,234,248],"inflammatory":[14],"diseases.":[15],"Obesity":[16],"associated":[18,211],"with":[19,71,170,184,188,212],"chronic":[20],"inflammation":[21],"and":[22,31,40,45,53,55,61,78,101,110,124,133,147,157,167,197,208,222,229],"low":[23],"adiponectin,":[24,72],"an":[25],"anti-inflammatory":[26,38],"adipokine.":[27],"Adiponectin,":[28],"5-aminoimidazole-4-carboxamide-1-4-ribofuranoside":[29],"(AICAR)":[30],"metformin":[32,146],"activate":[33],"the":[34,41,119,122,142,162,192],"AMP-kinase":[35],"that":[36,219],"exerts":[37],"effects,":[39],"influence":[42],"of":[43,121,181,194],"adiponectin":[44,130],"these":[46],"drugs":[47],"on":[48],"monocytic":[49,182,189,220],"was":[51,106,112,138,153,164,177,201,209],"analysed,":[52],"cellular":[54,132],"sCD163":[56,111,137,160,172,183,200,224],"were":[57,69,80],"determined":[58],"obesity":[60,241],"type":[62,83],"2":[63,84],"diabetes.":[64],"MATERIALS":[65],"AND":[66],"METHODS:":[67],"Monocytes":[68],"incubated":[70],"AICAR":[73,148],"or":[74,96],"metformin.":[75],"Furthermore,":[76],"monocytes":[77,123],"serum":[79,171,185,193],"obtained":[81],"from":[82],"diabetic":[85],"patients":[86],"(T2D),":[87],"overweight":[88],"(defined":[89],"as":[90],"body":[92],"mass":[93],"index":[94],">":[95],"=":[97],"25":[98],"kg":[99],"m(-2))":[100],"normal-weight":[102],"(NW)":[103],"controls.":[104],"analysed":[107],"by":[108,114],"immunoblot":[109],"measured":[113],"enzyme-linked":[115],"immunosorbent":[116],"assay":[117],"supernatants":[120,163],"serum.":[126],"RESULTS:":[127],"In":[128,191],"monocytes,":[129],"reduced":[131],"surface":[134],"CD163,":[135],"whereas":[136,159],"not":[139,165,187],"altered":[140],"corresponding":[143],"supernatants.":[144],"Further,":[145],"downregulated":[149],"CD163.":[150],"Monocytic":[151],"higher":[154,203],"T2D":[156,198,228],"obesity,":[158],"neither":[168],"correlated":[169],"nor":[173],"systemic":[174,213,223],"adiponectin.":[175],"There":[176],"positive":[179],"correlation":[180],"but":[186,236],"IL-6.":[190,214],"obese":[195],"controls":[196],"patients,":[199],"significantly":[202],"compared":[204],"to":[205,240],"NW":[206],"donors":[207],"positively":[210],"CONCLUSIONS:":[215],"This":[216],"study":[217],"indicates":[218],"are":[225],"obesity.":[230],"Adiponectin":[231],"reduces":[232],"vitro,":[235],"additional":[237],"factors":[238],"related":[239],"like":[242],"IL-6":[243],"may":[244],"be":[245],"more":[246],"relevant":[247],"vivo.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}